Data indicate that human CD4+ mucosal-associated invariant T cell TCRs may be selected by alternative MR1 ligands in addition to canonical riboflavin intermediates. Find this #TopRead article from @charlesvorkas.bsky.social and team online: ow.ly/hcNc50XYarT.

We are pleased to share our new publication linking TRAV1-2 negative MAIT cells, CD4 coexpression, and tuberculosis. A conserved innate-like T cell subset with more TCR diversity than previously appreciated. academic.oup.com/jimmunol/adv... #Immunology #maitcells #TCRdiversity

Thank you @bsheridanlab.bsky.social. We are excited about sharing this work, particularly in light of parallel findings in IV BCG vaccination models in macaques that demonstrate CD8aa+ lymphocytes are critical for controlling Mtb. Can NK cells recognize specific MHC I-epitope complexes? TBD