Alicia Che
@aliciache.bsky.social
📤 167
đź“Ą 138
đź“ť 6
Asst prof @ Yale psychiatry, mom of 2
pinned post!
Was hoping to share good news at a better time but realized it may not come for 4 years, so here it is! First paper from the lab. We show a transient L5 to L2/3 connection in developing cortex that drives activity-dependent maturation of upper-layer circuits.
www.nature.com/articles/s41...
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Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex - Nature Communications
The development of translaminar cortical circuits remains incompletely understood. Here authors show cortical layer 5 provides translaminar inputs to layer 2/3 during development, strengthening layer ...
https://www.nature.com/articles/s41467-024-55783-w
12 months ago
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reposted by
Alicia Che
Matt Girgenti
8 months ago
Very proud of our new
#SingleCell
work on
#PTSD
and
#MDD
out in
@nature.com
today. Paper:
www.nature.com/articles/s41...
News and views:
www.nature.com/articles/d41...
Press:
medicine.yale.edu/news-article...
Data:
doi.org/10.5281/zeno...
Code:
github.com/mjgirgenti/P...
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Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD - Nature
A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.
https://www.nature.com/articles/s41586-025-09083-y
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reposted by
Alicia Che
Yale Kavli Institute for Neuroscience
9 months ago
In a new
@yale.edu
study, researchers led by
@mattgirgenti.bsky.social
from
#YalePsychiatry
used a comprehensive multi-omic approach to analyze postmortem brain 🧠genomics and investigate the molecular differences 🧬 in PTSD and major depressive disorder 🔍
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A Multi-Omic Approach Implicates Novel Protein Dysregulation in Post-Traumatic Stress Disorder
Yale scientists, led by senior author Matthew Girgenti, PhD, assistant professor of psychiatry, established a brain multi-omic and multi-region analysis
https://medicine.yale.edu/news-article/a-multi-omic-approach-implicates-novel-protein-dysregulation-in-post-traumatic-stress-disorder/
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3
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reposted by
Alicia Che
Matt Girgenti
9 months ago
Excited to share our latest study of the PTSD prefrontal cortex out @GenomeMedicine.
rdcu.be/ejZ3T
Our systems biology approach established a brain multi-omic, multi-region analysis comprising individuals with PTSD and MDD
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A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
https://rdcu.be/ejZ3T
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5
3
reposted by
Alicia Che
Alex Kwan
10 months ago
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄 Read in
@nature.com
-
www.nature.com/articles/s41...
1/12
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Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature
A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
https://www.nature.com/articles/s41586-025-08813-6
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Soohyun is a friend and colleague who is kind, generous, and absolutely brilliant. Sending love. We stand together ❤️
add a skeleton here at some point
11 months ago
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0
reposted by
Alicia Che
Mark Cuban
12 months ago
This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
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How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
https://globalnews.ca/news/9793403/ozempic-canada-scientist-venomous-lizard-weight-loss/
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12912
reposted by
Alicia Che
Ezra Levin ❌👑
12 months ago
Folks trying to save USAID are trying to counterprogram Musk's $40 million Super Bowl ad. They're asking everyone to share this video as widely as you can today:
www.youtube.com/watch?v=PqUE...
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https://www.youtube.com/watch?v=PqUESHfuO_8
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2010
1942
reposted by
Alicia Che
Sam Bagenstos
12 months ago
Indirect Costs and Trump's Attack on Independent Voices. My latest post:
buttondown.com/sbagen/archi...
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Indirect Costs and Trump's Attack on Independent Voices
By Samuel Bagenstos A strong democracy requires a robust independent sector. Organizations and associations that stand apart from the governing state regime...
https://buttondown.com/sbagen/archive/indirect-costs-and-trumps-attack-on-independent/
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It’s not easy to keep a cool head with muzzle velocity. Great article. Will share with all my trainees. (Gift without paywall)
www.nytimes.com/2025/02/02/o...
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Opinion | Don’t Believe Him (Gift Article)
Look closely at the first two weeks of Donald Trump’s second term and you’ll see something very different than what he wants you to see.
https://www.nytimes.com/2025/02/02/opinion/ezra-klein-podcast-trump-column-read.html?unlocked_article_code=1.vU4.wt-H.om8DeRr6Jj-w&smid=nytcore-ios-share&referringSource=articleShare
12 months ago
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Was hoping to share good news at a better time but realized it may not come for 4 years, so here it is! First paper from the lab. We show a transient L5 to L2/3 connection in developing cortex that drives activity-dependent maturation of upper-layer circuits.
www.nature.com/articles/s41...
loading . . .
Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex - Nature Communications
The development of translaminar cortical circuits remains incompletely understood. Here authors show cortical layer 5 provides translaminar inputs to layer 2/3 during development, strengthening layer ...
https://www.nature.com/articles/s41467-024-55783-w
12 months ago
2
14
2
reposted by
Alicia Che
Daniel Gonzales
about 1 year ago
Really proud to see my postdoc work out!! We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging
www.science.org/doi/10.1126/...
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Touch-evoked traveling waves establish a translaminar spacetime code
Translaminar spacetime patterns organized by feedback-dependent cortical circuits support sparse traveling waves.
https://www.science.org/doi/10.1126/sciadv.adr4038
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reposted by
Alicia Che
Konrad Kording
about 1 year ago
Dendrites doing AI problems, so great to see the increased activity!
www.nature.com/articles/s41...
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Dendrites endow artificial neural networks with accurate, robust and parameter-efficient learning - Nature Communications
Artificial neural networks, central to deep learning, are powerful but energy-consuming and prone to overfitting. The authors propose a network design inspired by biological dendrites, which offe...
https://www.nature.com/articles/s41467-025-56297-9
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