Sharing here as well — consider adding this to your or your fav llm’s reading list if you want a dive into 1) protein folding, 2) limitation of AlphaFold and what it learned. You could be one step closer to solve the protein folding problem. www.nature.com/articles/s41...

How does ramen assemble in warming soup — the ultimate scientific challenge 🍜 - Entropy-driven noodle arrangement - Hydration kinetics - Diffusion and buoyancy activated topping sorting …

An Evaluation of Biomolecular Energetics Learned by AlphaFold by Lyu, Herschlag et al doi.org/10.1101/2025... Interesting comparison of AF2/3 structures with the PDB (AF2 appears better) Reminder: The PDB itself is probably biased relative to solution conformational ensembles and energetics

Ever wanted to predict protein NMR chemical shifts accurately and very very fast ? Great new paper from MIkailya Darrows @mdarrows.bsky.social. chemrxiv.org/engage/chemr... Comments are welcome !

For those following the @prof-ajay-jain.bsky.social /Cleaves/ @wpwalters.bsky.social preprint re: DiffDock @gcorso.bsky.social I have read some of the back-&-forth between the author groups As a practitioner in the field for > 20 yrs (academic side), here is my take: 🧵

Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science. www.biorxiv.org/content/10.1...