@robbieclark.bsky.social
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reposted by
Nature Chemistry
20 days ago
Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes
#chemsky
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Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes
Nature Chemistry, Published online: 10 June 2026; doi:10.1038/s41557-026-02155-0The extent to which crystal packing constrains protein dynamics is hard to decipher. Now a combination of NMR, crystallography and molecular dynamics simulations show that intermolecular contacts can slow ring flips down in crystals or accelerated them in complexes. A thermodynamic and structural analysis provides insights into the origins of the elevated free-energy barrier in crystals.
http://dlvr.it/TSz7XN
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Had so much fun with this work! Check it out!
add a skeleton here at some point
2 months ago
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reposted by
Alek Kovalenko
2 months ago
Having heard updates on this project at many stages from
@robbieclark.bsky.social
I can say that this is an amazing work. Congratulations to everyone on the team and to Robbie 🎉
add a skeleton here at some point
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reposted by
Nature Chemical Biology
about 1 year ago
A Perspective by
@stephanieaw.bsky.social
and
@fraserlab.com
discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery
www.nature.com/articles/s41...
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Advances in uncovering the mechanisms of macromolecular conformational entropy - Nature Chemical Biology
Protein conformational entropy plays a vital role in functions like binding and catalysis. This Perspective discusses three ways macromolecules use conformational entropy: prepaying entropic costs, re...
https://www.nature.com/articles/s41589-025-01879-3?utm_source=twitter&utm_medium=social&utm_campaign=nchembio
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reposted by
Syma Khalid
over 1 year ago
New study led by
@georgiaisom.bsky.social
and Ben Cooper. Sims by Robbie Clark. Exps & sims reveal phospholipid transport across the bacterial periplasm through the envelope-spanning bridge YhdP
www.sciencedirect.com/science/arti...
@dunnschool.bsky.social
@oxfordbiochemistry.bsky.social
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Phospholipid transport across the bacterial periplasm through the envelope-spanning bridge YhdP
The outer membrane of Gram-negative bacteria provides a formidable barrier, essential for both pathogenesis and antimicrobial resistance. Biogenesis o…
https://www.sciencedirect.com/science/article/pii/S0022283624005217
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reposted by
Syma Khalid
over 1 year ago
In a multidisciplinary study led by Georgina Benn and Tom Silhavy we show the role of OmpA in controlling the organisation of the outer membrane and in sharing the mechanical load.
www.pnas.org/doi/10.1073/...
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2416426121
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