Fabien Degalez (@fdegalez.bsky.social)

Do you work in 💫human genetics💫? Have you ever worried about what’s inside your gene annotation GTF⁉️ WELL, YOU SHOULD! 😱 Especially when studying a genetically diverse 🌍 cohort! 🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses! Don't miss this thread🧵⬇️ 1/13

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Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic... https://www.biorxiv.org/content/10.1101/2025.03.14.643250v1