Yildiz Tasdan
@yildiztasdan.bsky.social
📤 127
📥 154
📝 2
Postdoctoral researcher in medicinal chemistry and drug discovery
Our recent preprint, “Exploiting a Cryptic Pocket in DsbA Through Structure-Guided Parallel Synthesis and Direct-to-Biology Screening,” is now available on ChemRxiv.
chemrxiv.org/engage/chemr...
loading . . .
Exploiting a Cryptic Pocket in DsbA Through Structure-Guided Parallel Synthesis and Direct-to-Biology Screening
Antibacterial resistance is a major global health problem, causing an increasing number of deaths worldwide. DsbA, a bacterial oxidoreductase enzyme, is pivotal for the correct folding and activity of...
https://chemrxiv.org/engage/chemrxiv/article-details/68ba23f6728bf9025e6d8c1f
5 months ago
0
2
1
reposted by
Yildiz Tasdan
Keith Hornberger
10 months ago
J Med Chem is on 🔥 with the editorials lately, and I highly recommend giving this one a read. Understanding free drug principles is the gateway to all of pharmacology, and is all too often mangled and misapplied by drug discovery practitioners.
loading . . .
Free Drug Concepts: A Lingering Problem in Drug Discovery
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c00725
5
47
13
reposted by
Yildiz Tasdan
Scott Bagley
12 months ago
#ChemSky
cleanser The annual
#JMedChem
article on Synthetic Approaches to the New Drugs Approved during 2023 is out now with industry authors from Takeda, Crosswalk, Merck and Pfizer A great reference for anyone interested in the synthetic chemistry we use in pharma
loading . . .
Synthetic Approaches to the New Drugs Approved during 2023
This review is the next installment of an annual series that discusses the synthetic routes to access 28 small molecule drugs that were approved worldwide in 2023. A brief description of each drug’s mechanism of action, the history of its discovery and development, and the synthetic approaches published in primary or patent literature that were most likely used for clinical studies or development are included. Synthetic chemistry, used to convert complex intermediates to active compounds or build a new drug from basic building block chemicals, is critical to delivery of new drugs and treatments for disease to patients.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c02079?articleRef=control#
0
28
5
reposted by
Yildiz Tasdan
Jake Yeston
about 1 year ago
chemistry
add a skeleton here at some point
0
19
3
reposted by
Yildiz Tasdan
Scott Bagley
about 1 year ago
From the other place and the amazing Journal of Immaterial Science An absolute must read for
#ChemSky
Link in comment below
2
36
6
reposted by
Yildiz Tasdan
Saloni
about 1 year ago
Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly. Just how many types of antibiotics were discovered during that time? So, I visualized it myself!
23
1107
405
reposted by
Yildiz Tasdan
ChemRxiv Bot
about 1 year ago
Identification of an Allene Warhead that Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA Authors: Yildiz Tasdan, Gautham Balaji, Naureen Akhtar, Olga Ilyichova, Taylor Cunliffe, Begona Heras, Loic Le Strat, ... DOI:
10.26434/chemrxiv-2024-pmf6p
0
1
1
you reached the end!!
feeds!
log in