New preprint + thread 🧵 #Psychedelics induce the formation of new synapses, but where do they connect? Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks. www.biorxiv.org/content/10.1... 1/12

People have warned about #psychedelics and 5-HT2B receptor activation for years — citing potential cardiotoxicity. But no one had tested it. Until now. We used echocardiography to assess cardiac risk after chronic LSD microdosing in mice. @sthom003.bsky.social www.biorxiv.org/content/10.1...

Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄 Read in @nature.com - www.nature.com/articles/s41... 1/12

Can whole-brain imaging of cellular c-Fos signals be used to classify #psychedelics? 🧠🔬💊 Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs. Paper here 👇 www.nature.com/articles/s41...

On tonight: Given that classical #psychedelics are 5-HT2B agonists, there is concern of a potential cardiovascular risk with prolonged use. To resemble human context, we chronically administered 2 low doses of LSD and performed echocardiograms at baseline, 4-, and 8-weeks. #ACNP2024

Look forward to #ACNP2024 🧠💊☀️ I am glad to organize a Tuesday panel with @bita137.bsky.social on "Manipulation of aversive events and memories by psychedelics" Followed by Tuesday posters by current and past lab members @pashadavoudian.bsky.social and Sarah Jefferson