New BCR reconstruction tool for scRNA-seq: assembles full heavy & light chains and annotates constant regions. Check it out: www.biorxiv.org/content/10.1... #scRNAseq #immunology

Interested in BCR analysis, including paired heavy-light chain and constant region?👀 Check out our new tool for reconstructing BCRs from scRNAseq! Compatible with 10x and Smart-seq🧬 www.biorxiv.org/content/10.1...

*constant*ly amazed 🧬

Check out long-read sequencing results in human IGH! HUGE duplications in constant gene regions...and 7 copies of IGHV3-23 on one haplotype! @lossiusandreas.bsky.social @williamlees.bsky.social www.biorxiv.org/content/10.1...

Our collaborative paper on #Nanopore sequencing is now available on #BioRxiv. Among several new variants, we characterize a large duplication in the IGHC region, suggesting non-canonical class switching between the duplicated isotypes in #Bcells. www.biorxiv.org/content/10.1...