50 years ago, Alexander Shulgin showed that 4-alkylated 2,5-dimethoxyamphetamines peak in potency with 2–3 carbon chains. We suggest longer chains reduce psychedelic-like effects mainly due to poor brain penetration, not reduced receptor activity. doi.org/10.1038/s413... #psychedelics

A recent study suggests that no dose adjustment of #LSD is necessary in the presence of an SSRI that inhibits CYP2D6. #psychedelics ascpt.onlinelibrary.wiley.com/doi/10.1002/...

Acute dose-dependent effects and self-guided titration of continuous #DMT infusions. www.nature.com/articles/s41...

Nice to meet you all here! 1) I began with characterizing designer drugs and later transitioned to bioanalysis of psychedelics 2) I'm mostly setting up methods for the bioanalysis of upcoming phase I studies 3) Arrested Development is my favorite TV show—I should watch it once again soon

Here is a starter pack I put together featuring all the psychedelic science researchers and journalists I could find on here. Let me know who I'm missing. It'd be great to get the conversation going on this platform go.bsky.app/NPvFX41

Thrilled to share the final product for an excellent collaboration with A. Sherwood & co at Usona Institute 😎. Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below: pubs.acs.org/doi/10.1021/...

Very nice early Christmas gift from our research group. Some insights into Albert Hofmann's work at Sandoz from the Novartis archives. A very nice read while waiting for the mass spec to measure our latest LSD plasma samples. #psychedelics #neuroskyence