Jesus Alvarado-Valverde (@jesusav.bsky.social)

Check out our latest research! Using a motif predictor and AlphaFold models, we designed experiments to validate their interaction interfaces and tested the effects of uncharacterized variants on binding, then predicted the effects of hundreds of them. www.biorxiv.org/content/10.1...

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Variant characterization in the intrinsically disordered human proteome Variant effect prediction remains a key challenge to resolve in precision medicine. Sophisticated computational models that exploit sequence conservation and structure are increasingly successful in t... https://www.biorxiv.org/content/10.1101/2025.06.27.661911v1