Just wanted to let you know that the IRS has audited every president annually for decades now to ensure there was no corruption and the reason you didn't know that was because only one president found that to be a problem

Best view I have ever had from a vendor booth. Visit us today or tomorrow at ACC in San Diego

This is easily the saddest time in American history. The absolute worst people are systematically destroying the country, and our system is completely failing to stop them.

Today's Nabsys press release aligns well with our presence in San Diego for ACC. I will be speaking Wednesday morning on progress towards detecting Robertsonian translocations using EGM www.prnewswire.com/news-release...

We’re looking forward to attending the Cold Spring Harbor Laboratory Biology of Genomes meeting this year. Poster #129: Electronic Genome Mapping for High-Throughput Analysis of Repeat Expansion Disorders presented by Syndi Koltz, Application Scientist at Nabsys Thurs, May 7, 7:30-10:30 PM #BOG26

I saw this yesterday. I love when words have multiple meanings.

The irony of having Trump telling us Spaniards that we are fantastic people but that he could not say the same of our Government. We think the same about your country. Really great people, terrible leaders.

In an ironic twist, it looks like dinosaurs will drive humanity to extinction.

The Texas legislature rammed through a gerrymandering bill at the request of Trump. Virginia actually voted in favor of redistricting to counterbalance what Texas and other Republican-controlled states have done. Yet only one is considered a "power grab." Oligarch-owned media in a nutshell.

In February 1777, General George Washington ordered the first mass immunization campaign in American history by mandating that his troops be inoculated against smallpox. He protected the Continental Army from an epidemic that was deadlier than British forces. 249 years later, we have this idiot.

I think most people would prefer this. #Science

It's really something to be living through the worst President, the worst Supreme Court, and the worst Congress all at once

www.golocalprov.com/business/nab... #nabsys

Throughout my entire Canadian Military Career I served alongside USAF personnel daily. We were a team, brothers and sisters in support of one goal, maintaining North American air sovereignty. More than colleagues, we were best friends, I bet many feel the same to this day. This all day Long 👇

I showed this graph in class yesterday on how measles cases in the United States plummeted dramatically after the vaccine was licensed in 1963. It’s not subtle and I could not resist observing: “This stunning design in measles cases was not thanks to vitamin A. It was not due to beef tallow.”

This is an excellent summary of current circumstances Kyle Kulinski: “A sundowning president with Alzheimer’s who’s a malignant narcissist is dragging us into WWIII, committing war crimes on a daily basis and crashing the global economy, and nobody is actually grabbing the steering wheel.”

Tens of thousands marching in Providence today. No kings.

Spread this dear ones: "Bernie Sanders is suggesting the Epstein files be read during the filibuster on the SAVE Act this week. Let's get this to TREND! Answered that for you

Nabsys: Snow or rain in the forecast? We’ve got you covered - literally. Stop by our booth #2007 and grab an umbrella before heading out! 👉 Visit us on the trade show floor or book a meeting with us: hubs.ly/Q046BKDj0 #ACMG #ACMG26 #ACMGMtg26 #GenomicResearch #EGM

This would be a crime against humanity, but otherwise I agree. .

> @covie93.bsky.social

will be back at same site in Orlando next year, March 1-4, 2027 #AGBTGM26

Beth Shapiro and Len Pennacchio to make closing remarks. That's it! Thanks for coming. Any feedback? #AGBTGM26

JO: DIstinct genomic compartmentalization of hypo- and hyper-methylation in cancer. Tumors share methylation states across distinct lineages. May be able to subtype cancers, use for liquid biopsy for tumor origin, identify cancer specific regulatory alterations #AGBTGM26

JO: Are there conserved methylation across cancers or cancer-type profiles? Contaminating cell types can obscure patterns. Can deconvolve cell types. #AGBTGM26

JO: see focal hypermethylation and global hypomethylation. Cancer atlas has data on 450K sites, only 1-2% fo methylome. Can now do whole methyome. Looked at 106 tumors from 21 cancer types #AGBTGM26

James Occean from Stanford will discuss whole genome profiling DNA methylation in primary tumors. Epigenetic alterations extensive in cancer #AGBTGM26

YM: longer reads can be better assigned to maternal/paternal allele to see imprinting #AGBTGM26

YM: use 5' kit and do long read 1. See extra cap G not genomically encoded in reads if goes all the way to 5' end. Do not see with premature termination to remove noise. See major start site but can also now see minor start sites previously hidden in noise #AGBTGM26

Yasuhiro Murakawa from Kyoto talking about spatial transcriptomics technology for transcription start site profiling #AGBTGM26

JB: another patient has main outlier at AS3MT, implicated in broad set of neuropsychiatric disorders. Depletion leads to increase in nerve, brain and muscle transcripts #AGBTGM26

JB: Use CRISPR guides to remove highly expressed RNA. 400,000 guides made. See highly expressed genes go down, poorly expressed go up. Uncover novel splice sites as in KCNJ6 only identified in depletion #AGBTGM26

JB: Of those with rare disease tested, 25-50% get a causal variant. RNAseq used to help interpret DNA mutations #AGBTGM26

Jon Bezney from Stanford will talk about rare disease diagnostics especially using RNAseq #AGBTGM26

EK: you can sign up your pet for pets on the ark. Free to sign up, $150 if want to have sequenced #AGBTGM26

EK: Are cats domestic? Yes, 4000 yrs ago: Evolution in response to an anthropogenic niche. A domestic population requires acces to that niche. #AGBTGM26

EK: Panagram counts kmers to compare genomes. very fast way to compare similarity. Highly correlated with Minimap #AGBTGM26

EK: Can see trait effects on GWAS Howling associated with SCN3A. See many loci associated dog height. Very heretible. #AGBTGM26

EK: 80% of current dogs are free roaming, living off human garbage just like 20,000 years ago. Dog breeds are only 150 years old. (Dirty secret: EK has never owned a dog). Behavioral traits are not fixed in breeds. Variability within breeds exceeds variability across breeds. #AGBTGM26

Elinor Karlsson from UMass Med will talk about pet genomics due to ability to do longitudinal studies, detailed phenotypes, large populations and people love to tell you about their dogs #AGBTGM26

JB: Transcription does not restart after mitosis in RanGAP1 depleted nuclei. After first indiscriminate folding program, get second folding program. Without second program, TADs and Cohesin-mediated loops do not form #AGBTGM26

JD: Folded state of genome is the sum of many different processes working simultaneously. Driven solely by chromosome-intrinsic factors. See indiscriminate clustering of small active domains (cell type specific) #AGBTGM26

JD: chromosome folding very different in interphase vs mitotic cell. Compartmentalizaiton: Hetero- and eu- chromatin spatially segregated. Chromatin looping: fast looping of DNA #AGBTGM26

Job Dekker from UMass Med to talk on mitotic inheritance of chromosome folding programs. Battle in all your cells between protein machines to organize mitotic chromosomes. #AGBTGM26