How do you coordinate #experimental and #computational science work in your #research projects? In our team, scientists from each fields work side-by-side, leveraging individual expertise while cultivating an agile, #interdisciplinary environment. Best of both worlds!

How do immune disease-relevant variants rewire gene regulation in CD4+ T cells? In a collaboration led by Daniel Schraivogel and Lars Steinmetz at @embl.org, we combined two large-scale CRISPRi screens (4.1M cells) to map the downstream cascades of thousands of SNPs.

A Comment article published in Communications Psychology argues that the rush to study AI is producing a feedback loop of topical and methodological convergence, flattening scientific imagination and crowding out the pluralism needed to keep research adaptive. 🧪 #ArtificialIntelligence

‪📖 Read about Umite, our smart-seq3 UMI counting pipeline: Umite is robust, memory- and time efficient, and outperforms prior tools in UMI retrieval by 10-15 %, and already packaged in a reproducible Snakemake pipeline 🔗 doi.org/qsnx by Leo Carl Foerster et al. #umi #smartseq3 #singlecell

Congratulations to our fabulous HCA community for all the amazing science. The combined papers in the HCA publications list now have more than 100,000 citations! buff.ly/DKGxoPc 🖥️ 🧬 #Genomics #SingleCell #HumanCellAtlas

Happy to see this out now in Cell Genomics: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines: www.cell.com/cell-genomic...

1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.

8/ 🤘 For those about to rock (around the Christmas tree), we salute you 🎸🎄: Isabelle Seufert & our team from @dkfz.bsky.social & BioQuant & @akispapantonis.bsky.social, Philipp Mallm, @s-anders.bsky.social & Petros Kolovos labs with support from @spp2202.bsky.social & @mspacealliance.bsky.social.

📖 Our new pseudotime alignment tool ptalign identifies Wnt antagonist SFRP1 as central for glioblastoma cell activation, opening new avenues for patient stratification and therapeutic avenues. 🔗 lnkd.in/ees8bhNY by @Leo Carl Foerster, Oguzhan Kaya et al. #glioblastoma #pseudotime #neurobiology