Phil Knutson, PhD (@philknutson.bsky.social)

This paper is really cool. Great synthesis but I really love the highlighting of the functional groups or areas of the molecule that are changing/connecting in each step. It makes it much easier to follow #chemsky

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Total Synthesis of Enlicitide Decanoate We report the total synthesis of enlicitide decanoate, an orally bioavailable inhibitor of proprotein convertase subtilisin/kexin type 9 that is being developed for the treatment of atherosclerotic cardiovascular disease. It is a highly complex macrocyclic peptide with a significant number of nonpeptide structural elements that presents a daunting synthetic chemistry challenge. We describe the development of a convergent, efficient, and robust manufacturing process that enables the large-scale production of enlicitide. https://pubs.acs.org/doi/10.1021/jacs.4c15966