New work out in the from @ox.ac.uk looks into developing sex-specific human ventricular #electromechanical multiscale models. Given the importance of #biologicalsex in #CardiovascularHealth this could be a very important tool! sciencedirect.com/science/arti... #CardioSky

🧬 New pig models of neonatal #HCM show severe cardiac #hypertrophy and perinatal lethality from MYBPC3 and MYH7 mutations. Pigs were highly sensitive to sarcomeric gene disruption, developing severe HCM, suggesting they may not be ideal genetic models. 🔗 www.sciencedirect.com/science/arti...

12-week-old #ob/ob mice show mild DCM with no major structural changes in #MAMs. Proteins linked to lipid metabolism and stress response were increased in MAMs, while hypoxic stress triggered more cardiomyocyte death. www.sciencedirect.com/science/arti...

New paper out in our September issue from Bass-Stringer and colleagues @bakerresearchau.bsky.social looking at PI3K. Exploring a new #genetherapy to improve heart function in mice and sheep. sciencedirect.com/science/arti... #CardioSky

Calling all #immunofluorescence scientists! Teng et al. showed glyoxal enhances IF signal and co-localisation while reducing staining artifacts, making it a superior alternative to PFA in murine cardiac tissue research. www.sciencedirect.com/science/arti...

📈 Circulating adropin is linked to higher risk of #AKI in patients with acutely decompensated #heartfailure (#ADHF) after decongestive therapy. It outperformed conventional biomarkers like urinary ACR and NT-proBNP. #CardioRenal #Biomarkers www.sciencedirect.com/science/arti...

Kazantzi et al show that #MEK–ERK1/2 and #PKC pathways independently and synergistically modulate ETB receptor upregulation under flow cessation. These signalling axes may be promising targets for #cerebrovascular disease. Read more here! www.sciencedirect.com/science/arti...

New work just out from Fowler et al, invesigated the role of subthreshold #DADs on arrhythmia generation in #CPVT! Congrats to the Authors! sciencedirect.com/science/arti... #CardioSky

NIH-funded and need to publish in an open-access journal? JMCC Plus is fully OA and we're offering a 50% APC discount until 30 Sept 2025! Submit your work and join our growing community of cardiovascular researchers. #OpenAccess #Cardiac #Research www.sciencedirect.com/journal/jour...

New in JMCC Plus: This study presents a multidimensional analysis to investigate culture-induced alterations in living #myocardial slices, demonstrating structural integrity despite changes to slices’ functional and #molecular profiles Read more here! www.sciencedirect.com/science/arti...

Exciting news! Clarivate has released the inaugural #ImpactFactor for 2024, and JMCC Plus, just 3 years since its launch, has earned a spot in Q2! A huge thank you to our authors, reviewers, and readers for helping us reach this milestone. #AcademicPublishing #JMCCPlus

Heart failure alters organelle dynamics. Latchman et al. reveal striking shifts in failing cardiomyocytes- more rounded #mitochondria, disrupted SR-mitochondria juxtaposition and altered lipid droplet size across #heart #failure types . www.sciencedirect.com/science/arti... ‪@upenn.edu @temple.edu‬

New #CardioBreakthrough: Gemfibrozil—beyond lipid-lowering—blocks caspase‑11‑driven pyroptosis in mouse hearts, reducing infarct size during ischemia/reperfusion. A promising repurposed therapy post-#AMI! Congratulations to all authors. Want to know more?

Looking for some weekend reading? We recently published some work from Chambers et al. looking at the effect of an #SGLT2i on #mitochondrial function from non-diabetic mice with #Cardiomyopathy Accompanied by a very nice editorial! sciencedirect.com/science/arti...

Are you looking for a new model of arrhythmia? Maybe performance horses are the answer! Great work just out from Avison et al! www.sciencedirect.com/science/arti...

The JMCC and JMCC Plus Reception is in full swing at #ISHR World Congress 2025! A great opportunity to bring our editorial team and reviewers together, while hearing from JMCC #EiC Rong Tian and JMCC Plus #EiC @davorpavlovic.bsky.social

The 25th World Congress of #ISHR 2025 in Nara, Japan, has officially begun with over 1000 members attending! A fantastic start to the conference, welcomed by traditional Japanese music, before hearing from this years' ISHR awardees. @ishr-aus.bsky.social

Looking for some weekend reading or on your way to the ISHR meeting in Japan? Check out the recent work from Alican Guran, @k8weeks.bsky.social et al. investigating the role of B56α as a mediator of cardiac responses to β-AR stimulation! sciencedirect.com/science/arti...

A recent study found that women undergoing cardiac surgery show reduced CD39/CD73 expression and greater #fibrosis. Using a #CD39 mimetic and #CD73 enhancer improved cardiac function and reduced fibrosis in an ovariectomy + high-fat diet mouse model. Read more: www.sciencedirect.com/science/arti...

New Paper Alert! New work just published investigated the differences in the #electrophysiology of the left and right stellate ganglia What repercussions may this have for #Arrhythmia generation? Congrats to the Authors and thanks to the Reviewers! sciencedirect.com/science/arti... #CardioSky

Exciting news! Join us for another exclusive ISHR-ES webinar: The Beating Edge of Cardiac Metabolism! 🫀💡 📅 Friday, 7th March 2025 | ⏰ 14:00 to15:00 GMT + 1| 💻 Live Online Hear from three leading experts as they dive into cutting-edge research & innovations. 🔗 Register now: https://buff.ly/4aWIbv1

New research by Grazide and colleagues has revealed a novel biomarker for myocardial infarction risk. Rubicon, a negative regulator of autophagy, could aid in the early detection of individuals at high risk for MI Read more here: https://buff.ly/3WyWO1i

We are delighted to share that JMCC Plus is now officially indexed in PubMed Central (PMC)! Well done to all the editorial team, particularly our EiC @davorpavlovic.bsky.social and deputy @gundrylab.bsky.social 🎉

Can we predict survival after #CardiogenicShock? New research from researchers at Helsinki University and the Luxembourg Institute of Health show that a particular miRNA (miR-20b-5p) is associated with survival in cardiogenic shock! #CardioSky

Wishing everyone Happy Holidays from the #JMCCPlus team! 2024 has been a great year for the journal, but wouldnt have been possible without the hard work of the editors, reviewers, authors and readers, so thanks! Looking forward to what #2025 brings! #CardioSky

We are pleased to have recently published the abstracts from both the ISHR_ES and ISHR-Southeast Asia meetings.. Interested in the latest work presented there? Check out the following links! sciencedirect.com/journal/jour... sciencedirect.com/journal/jour... #CardioSky

In our December issue, fantastic research by Jiang et al. highlights how perivascular #fibrosis in intramyocardial blood vessels may play a key role in #myocardialinfarction (#MI) progression. Read more here: www.sciencedirect.com/science/arti...

Congratulation to the authors on this great piece of work just published in our journal! Learn more about it in the thread below from @dr-yktham.bsky.social

New paper alert! Work just out from Jensen et al looked at modeling immune checkpoint inhibitor associated myocarditis using in-vitro models. www.sciencedirect.com/science/arti... #Cardiosky #Medsky @mdanderson.bsky.social @tamu.bsky.social @davorpavlovic.bsky.social @gundrylab.bsky.social