🚨 New in JMCC! The GWAS-identified CAD risk gene and transcription factor PRDM16 is a key regulator of VSMC homeostasis, promoting proliferation and neointima formation by repressing Tgfb2 expression. www.jmcc-online.com/article/S002...

🚨 New in JMCC! Paired human LV and RV biopsy metabolomics reveal that ischemia-reperfusion causes greater metabolic depletion in the LV, especially during CABG, highlighting ventricle-specific vulnerabilities in cardiac surgery. www.jmcc-online.com/article/S002...

🚨 New in JMCC! Multi-omics approaches reveal that impaired VSMC TGF-β signaling drives mitochondrial dysfunction, contributing to the pathogenesis of thoracic aortic aneurysm and dissection. www.jmcc-online.com/article/S002...

🚨 New in JMCC! CDNF’s C-domain drives potent cardioprotection via PI3K/Akt signaling and mediates ER stress–dependent KDEL receptor binding, while the N-domain is essential for CDNF internalization. www.jmcc-online.com/article/S002...

🆕in JMCC: Single-cell analyses reveal activated, dysfunctional cardiac T cells in dilated cardiomyopathy. Distinct CD4⁺ subsets, including tissue-resident memory T cells, show pro-fibrotic signaling linked to ERα activity and systolic dysfunction 🫀 www.jmcc-online.com/article/S002...

🆕in JMCC: AAV-mediated delivery of WT TNNI3 rescues thin filament-mediated dilated cardiomyopathy in a murine model of Tnni3 mutation. Gene supplementation restored troponin function and prevented the development of heart failure🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: Transcription initiation factor TIF-1A regulates vascular smooth muscle contraction and blood pressure by controlling ribosome biogenesis. Smooth muscle-specific Tif-1a loss reduces vasoconstriction and protects against Ang II-induced hypertension 💪🏼 www.jmcc-online.com/article/S002...

🆕 in JMCC: Atrial t-tubules undergo dynamic postnatal remodeling as Ca²⁺ handling matures. Despite structural changes and reduced ICa-L and SR Ca²⁺, decreased Ca²⁺ buffering helps preserve Ca²⁺ transients during development 🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: JTC801 suppresses HIF-1α–mediated CA9 activation to trigger alkaliptosis in vascular smooth muscle cells, restoring intracellular pH homeostasis and reducing aortic dissection formation in a mouse model 👏🏼 www.jmcc-online.com/article/S002...

Check out this 🆕 article in JMCC: METTL3-driven m6A modification enhances LGMN translation via YTHDF1, promoting macrophage ferroptosis and accelerating atherosclerosis. Targeting this pathway may offer new therapeutic opportunities 🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: Genetically encoded biosensors reveal real-time redox dynamics in cytosol and mitochondria of live cells. The study shows metabolic pathways shape compartmental redox balance and that mitochondrial redox status is highly sensitive to stress ⚡️ www.jmcc-online.com/article/S002...

🆕 in JMCC: Acetylation of ACTC1 at K326 and K328 weakens actin-tropomyosin interactions and reduces thin filament inhibition under low Ca²⁺, promoting contractile activation. New work reveals how actin modification can tune cardiac thin filament regulation 🫀 🦾 www.jmcc-online.com/article/S002...

🚨 🆕 in JMCC: Circadian rhythms are essential for cardiovascular health, yet hypertension & heart disease can disrupt the molecular clock itself. This review explores the bidirectional relationship between circadian biology, blood pressure, and CV disease 🕰️ 🫀 www.jmcc-online.com/article/S002...

New Review in JMCC! Hulsurkar et al. examine how localized cAMP signaling controls ryanodine receptors in healthy and failing hearts, shedding light on Ca²⁺ handling and arrhythmia risk. www.jmcc-online.com/article/S002...

New Review in JMCC! Tadros et al. explore how single cell/nucleus RNA sequencing is transforming our understanding of adult and pediatric non-ischemic cardiomyopathy. These cutting-edge tools are critical for advancing precision cardiovascular medicine. www.jmcc-online.com/article/S002...

New in JMCC! Miller et al. use a population-based simulation approach to uncover arrhythmia risk in heart failure. The framework captures both intrinsic cellular variability and disease remodeling in human ventricular myocytes. www.jmcc-online.com/article/S002...

New in JMCC! Sphingomyelinase induces the swelling-activated chloride current via production of S1P and mitochondrial ROS- a pathway relevant to cardiac and metabolic diseases. www.jmcc-online.com/article/S002...

New insights into cardiac hypertrophic remodeling now in JMCC! 🎉 Song et al. reveal that impaired RARβ suppresses Rbm20 and disrupts CaV1.2 alternative splicing to drive remodeling. Excitingly, RARβ agonism alleviates hypertrophy! www.jmcc-online.com/article/S002...

Join us in Minneapolis for the 2026 ISHR North American Section Meeting! 📍 Minneapolis, MN 📅 May 31–June 3, 2026 Promoting the next generation of basic and translational scientists. Reserve your spot today! #ISHRNAS2026 ishrnorthamerican.org/meetings/

New in JMCC! Atrial muscle fibers show reduced length-dependent activation but faster force development than ventricular muscle. Differences are driven by passive stiffness and cross-bridge kinetics highlighting chamber-specific mechanics in the human heart. 🫀 www.jmcc-online.com/article/S002...

🚨 New insight into I/R injury: Zhao and colleagues identify ZIP14 as a key driver of damage via iron overload, ferroptosis, and lysosomal dysfunction. Even better? Lowering ZIP14 reduces infarct size. www.jmcc-online.com/article/S002...

Arrhythmias are common in PAH. New work in JMCC shows that treating PAH murine models with e-CAMP significantly reduces cardiac arrhythmias while also improving pathological cardiac and pulmonary vascular remodeling. www.jmcc-online.com/article/S002...

New work in JMCC shows that Pyk2 is critical for hypoxia and adrenergic stress driven Cx43 internalization and cardiomyocyte damage. www.jmcc-online.com/article/S002...

🚨🆕in JMCC Special Section: The Diabetic Heart This review highlights the angiotensin type 2 receptor (AT2R) as a therapeutic target in diabetic cardiomyopathy. Preclinical data show AT2R agonists ⬇️ inflammation & fibrosis & improve cardiac function. www.jmcc-online.com/article/S002...

🚨 🆕in JMCC Special Section: Better Together - Exp+comp models in cardiac remodeling. This study shows lactation prolongs postpartum heart growth in mice, while non-lactation reverses hypertrophy. Modeling reveals complementary mechanical and biological drivers. www.jmcc-online.com/article/S002...

🆕in JMCC: IGF-1 accelerates cardiac pacemaking by increasing cell surface expression of HCN4 channels in the sinoatrial node. This effect depends on Rab11-mediated endocytic recycling, offering a mechanistic explanation for IGF1-associated tachycardia. www.jmcc-online.com/article/S002...

🆕in JMCC: In silico modeling reveals how stretch-activated ion channels drive ventricular re-entry. Arrhythmias emerge from interactions between stretch-induced depolarization and repolarization, shaped by stimulus timing, spatial gradients, & tissue properties. www.jmcc-online.com/article/S002...

🆕in JMCC: PhysioMEA is a new open-source platform for advanced MEA analysis of cardiac organoids. It expands beyond 1D metrics to 2D electrophysiological biomarkers and beat rate variability, revealing complex spatiotemporal rhythm dynamics. www.jmcc-online.com/article/S002...

🆕in JMCC: A small-scale siRNA screen identifies WWC2 as a key brake on cardiomyocyte mitosis. Loss of WWC2 activates YAP signaling, enables cytokinesis, and stimulates cardiomyocyte proliferation and cardiac regeneration after myocardial infarction. www.jmcc-online.com/article/S002...

🆕in JMCC: Fibroblast-specific USP7 drives post-MI cardiac fibrosis by stabilizing KLF7 and activating pro-fibrotic GATA3 signaling. Genetic deletion of USP7 limits myofibroblast activation, improves cardiac function, and mitigates adverse remodeling. www.jmcc-online.com/article/S002...

🆕in JMCC: Soluble epoxide hydrolase drives HFpEF by reducing cardioprotective EETs and activating CYP2E1. Genetic or pharmacologic sEH inhibition restores EETs, improves diastolic function, and reverses adverse cardiac remodeling in HFpEF. www.jmcc-online.com/article/S002...

🆕in JMCC: Homocysteine drives thrombosis by activating endothelial thromboxane prostanoid receptors, triggering vWF secretion and platelet adhesion. Targeting TPr signaling reduces vWF levels and protects against hyperhomocysteinemia-related thrombosis. www.jmcc-online.com/article/S002...

🆕in JMCC: Loss of the RNA binding protein Qki disrupts cardiac homeostasis, driving cardiac cachexia and death via altered Morf4l2 splicing. Targeting the Morf4l2Δex3 isoform rescues heart function, revealing a new therapeutic avenue 🧬 🫀 www.jmcc-online.com/article/S002...

🆕in JMCC: Slit2-Robo signaling drives cardiac repair after MI. Fibroblast-derived Slit2 boosts angiogenesis, increases vascular density, limits cardiomyocyte hypertrophy, and improves function post-MI, highlighting a new therapeutic pathway for heart repair 💪🏼 www.jmcc-online.com/article/S002...

🆕in JMCC: FABP4 emerges as a marker of worse CVD prognosis🫀 Elevated FABP4 drives proinflammatory, proatherogenic neutrophil phenotypes, while semaglutide lowers FABP4 & dampens leukocyte migration & platelet activation pathways 💊 #JMCC #Atherogenisis www.jmcc-online.com/article/S002...

🚨 The January issue of JMCC is live! ⭐ Featured study: "The long non-coding RNA Snhg15 protects the heart after myocardial infarction". ⬇️Snhg15 is a hallmark of ischemic & dilated HF, while AAV-Snhg15 limits cardiomyocyte death & improves function after MI 🧬 🫀💪🏼 www.jmcc-online.com/article/S002...

Attention Early Career Investigators: ISHR-NAS is hosting a Winter Webinar on Dec. 4, featuring selected presentations from Post-Docs and PhD Students. Submit your abstract by Oct 31 to be considered for presentation. Learn more & register at ishrnorthamerican.org/eci/

JMCC and JMCC Plus are now on LinkedIn! Follow our joint JMCC Journals account at www.linkedin.com/company/jmcc...

Work from Patrick Boyle at University of Washington shows population-based computational simulations elucidate mechanisms of focal arrhythmia following stem cell injection Read more: doi.org/10.1016/j.yj...

Editor's Choice! The role of the troponin T interactions with actin in regulation of cardiac thin filament revealed by the troponin T pathogenic variant Ile79Asn doi.org/10.1016/j.yj...

From our Special Issue on Microvessels in the Heart, guest editors William Chilian, Puja Mehta, and colleagues provide a chronology of basic and clinical research in the coronary microcirculation: doi.org/10.1016/j.yj...

Attention Early Career Investigators! JMCC has launched a Call for Papers "Metabolic Contributions to Heart Disease: Insights from the Next Gen of CV Researchers". To be eligible, first or last authors must be an ISHR member and an ECI. More info here: www.sciencedirect.com/special-issu...

🚨 Editor's Choice! 🚨 Research from University of Arizona shows L348P point mutation in cardiac myosin binding protein-C alters transient responses to stretch, slows cardiac relaxation & is embryonic lethal in homozygous CRISPR gene-edited mice Read: doi.org/10.1016/j.yj...

Our journal reception at #ISHR2025 included recognition of Rong Tian for her service as Editor in Chief of JMCC. Her term ends in December 2025. Congratulations Rong for your excellent work on the journal!

Good morning #ISHR2025! Stop by our booth in the exhibition area to learn more about JMCC and @jmccplus.bsky.social. Hope to see you in Nara!

Work in our April issue offers a detailed cardioFISH protocol for #cardiomyocyte nuclear ploidy assessment. Available open access: doi.org/10.1016/j.yj...

In our April issue, Orlowski and colleagues describe for the first time that IRBIT plays a critical role in the pathophysiology of the heart. Cardiac hypertrophy induced by overexpression of IP3-released inositol 1, 4, 5-trisphosphate receptor-binding protein (IRBIT) : buff.ly/czTyHDW

Editor's Choice! Autoinhibition of cMyBP-C by its middle domains: www.sciencedirect.com/science/arti...

Perspective article from @dakheartguy.bsky.social assesses and interprets diastolic function in animal models of heart disease: https://buff.ly/3ZPqKZa

🚨 Open access alert! 🚨 Cardiac fat adipocytes: An optimized protocol for isolation of ready-to-use mature adipocytes from human pericardial adipose tissue: https://buff.ly/3Z4ZRyV