Kevin Johnson
@kevin-johnson.bsky.social
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Research Scientist in Department of Neurosurgery Yale University studying glioma evolution
reposted by
Kevin Johnson
Floris Barthel
about 1 month ago
This 7-year journey has reached a first milestone! 🥳 Excited to share our preprint (3rd of 2025) on the 3D telomeric interactome, a project that started with a K99 in 2018. Thanks to Yi-An Chen, first postdoc in our lab and first author who worked tirelessly to realize this dream.
bit.ly/3W3wuMk
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Mapping the Telomeric 3D Interactome with Telomere-C Reveals Repetitive Element Hubs Associated with Telomere Maintenance
Telomeres are essential for genome integrity, but the accurate, high-resolution mapping of their three-dimensional (3D) chromatin interactions, a process thought to mediate gene regulation and telomer...
http://bit.ly/3W3wuMk
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reposted by
Kevin Johnson
Cancer Cell
2 months ago
Online Now: Protein-based classification reveals an immune-hot subtype in IDH mutant astrocytoma with worse prognosis
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Protein-based classification reveals an immune-hot subtype in IDH mutant astrocytoma with worse prognosis
Tang et al. apply spatiotemporal multi-omics to define four proteomic subtypes of IDH-mutant astrocytoma. They highlight an immune/mesenchymal-enriched (IME) subtype marked by gemistocytic differentiation, immune infiltration, and poor prognosis. Their AI-powered toolbox, GUIDE, enables multi-omics-based classification and supports precision diagnostics in glioma care.
http://dlvr.it/TN5Knj
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reposted by
Kevin Johnson
Anna Golebiewska
2 months ago
Precision medicine in high-grade gliomas? Using high-throughput drug screen in
#NORLUX
patient-derived organoids multi-omics and machine learning, we assessed pharmacogenomics:
www.biorxiv.org/content/10.1...
@fnr.lu
,
#precisionmedicine
,
#organoids
,
#drugscreen
,
#pharmacogenomics
,
#braintumors
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Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas
Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profil...
https://www.biorxiv.org/content/10.1101/2025.09.09.675145v1
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reposted by
Kevin Johnson
Omer Ali Bayraktar
6 months ago
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace
#glioblastoma
heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing
bit.ly/4mkrWgs
& predict plasticity w. snRNA/ATAC+deep learning
bit.ly/3FbI6Ic
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reposted by
Kevin Johnson
Avishay Spitzer, MD, PhD
6 months ago
1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators
@masashi-nomura.bsky.social
,
@kevin-johnson.bsky.social
and Luciano Garofano, published at Nature Genetics
@natureportfolio.nature.com
!
www.nature.com/articles/s41...
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Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics - Nature Genetics
Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive ...
https://www.nature.com/articles/s41588-025-02168-4
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reposted by
Kevin Johnson
Masashi Nomura
6 months ago
1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today!
www.nature.com/articles/s41...
,
www.nature.com/articles/s41...
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The multilayered transcriptional architecture of glioblastoma ecosystems - Nature Genetics
Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with s...
https://www.nature.com/articles/s41588-025-02167-5
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reposted by
Kevin Johnson
Roel Verhaak
8 months ago
We are looking to recruit new postdocs! Please check
verhaaklab.com/archive/2025...
.
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postdoc opportunity - join our team! · Verhaak Lab
The Verhaak lab in the Department of Neurosurgery at the Yale School of Medicine is looking to recruit a postdoctoral associate who will help us develop new therapeutic approaches to treat patients wi...
https://verhaaklab.com/archive/2025-03-postdoc-opportunity-join-our-team/
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reposted by
Kevin Johnson
Steven Sloan
10 months ago
First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental
#glial
biology to
#stem
cells and
#tumor
biology.
rdcu.be/d5ADz
A 🧵
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Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma
Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...
https://rdcu.be/d5ADz
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