Is it possible to acutely activate an individual RAS GTPase in cells - without using upstream signalling or constitutive mutants. It is! Our SPaRTa approach lets us directly visualize effector recruitment and signalling following GTP-loading of a singlular GTPase. www.biorxiv.org/content/10.6...

SAVE THE DATE for the 13th Canadian Developmental Biology Conference — March 7–10, 2027 — bringing together researchers, trainees, and innovators in developmental biology from across Canada and beyond.

This was a true team effort. IRIC chemists generated complex macrocycles with the goal of targeting KRAS and my former postdocs Ryan Killoran and Changhwa Jo offered insights to how the macrocycles were targeting RAS using NMR and crystallography. This work continues! pubs.acs.org/doi/10.1021/...

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

Scientists at Canadian institutions have long punched well above our weight despite low and stagnant funding. Spending a billion dollars on external recruitment while science here is starving is exactly what Harper got wrong about supporting research excellence in Canada.

Nice collaboration with the Abankwa lab (University of Luxembourg) on development of peptide-based PDE6D inhibitors, and congrats to our shared PhD candidate Atanasio Gómez-Mulas! doi.org/10.1002/cbic...

I want to highlight this review from Laura Quirion (@jf-cotelab.bsky.social) and Regina Strakhova (my lab) on ARF GTPases. Great read on the atypical nature of ARF/ARL small GTPase signalling, and they make it clear there is still much we don't know! doi.org/10.3389/fmol...

love this work - super cool and nice thread explaining potential evolutionary implications

PhD Position – Cancer Signalling and Structural Biology Institute for Research in Immunology and Cancer (IRIC), Université de Montréal www.linkedin.com/posts/matthe...

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging www.biozentrum.unibas.ch/open-positio... #biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions. Descriptions and links in the following two posts.

Dear Canadian researchers, faculty, RAs, PDFs and grad students, this letter is for the federal party leaders asking them to defend and expand Canadian research sovereignty with a historic investment in science, please sign and share docs.google.com/document/d/1...

Cool review on a relatively understudied posttranslational modification: oxidation. Our colleagues in the Labbé lab at IRIC have been working to figure out the function of OSGIN proteins in cytokinesis - and its nicely summarized here! dx.doi.org/10.1080/1538...