Tim Sandle
@timsandle.bsky.social
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📥 285
📝 267
Professor Tim Sandle, PhD. Pharmaceutical microbiologist and science journalist
40 rules for working in cleanrooms - maybe there are more, less likely there are less. What do you think? Read my latest newsletter to find out!...and make a comment
www.linkedin.com/pulse/40-rul...
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40 rules for working in cleanrooms
Working in clean environments demands knowledge, discipline, motivation as well as a thorough understanding of contamination risks amongst all personnel involved. Each individual cleanroom should have...
https://www.linkedin.com/pulse/40-rules-working-cleanrooms-professor-tim-sandle-ph-d-cbiol-fisct-ptmne/
12 days ago
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Hayato Sumino has shown his talents, from paying tribute in Hiroshima to captivating crowds at Carnegie Hall
www.digitaljournal.com/entertainmen...
13 days ago
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reposted by
Tim Sandle
Microbes.Info
27 days ago
#People
close to you influence your
#gut
#bacteria
... |
#genetics
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#microbes
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#microbiome
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#DNA
| By
@timsandle.bsky.social
via digitaljournal .com
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People close to you influence your gut bacteria
Your genes may be shaping someone else’s gut bacteria through microbes you unknowingly share.
https://www.digitaljournal.com/life/people-close-to-you-influence-your-gut-bacteria/article
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Merry Christmas!
about 1 month ago
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FDA Issues Final Guidance For pH Adjuster Waiver Requests For Generic Drugs. The guidance sets out how the FDA intends to evaluate a request for a waiver for the standard requirements for qualitative or quantitative differences in pH adjusters:
www.drugdeliveryleader.com/doc/fda-issu...
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FDA Issues Final Guidance For pH Adjuster Waiver Requests For Generic Drugs
The FDA has issued a final guidance, Considerations for Waiver Requests for pH Adjusters in Generic Drug Products Intended for Parenteral, Ophthalmic, or Otic Use.
https://www.drugdeliveryleader.com/doc/fda-issues-final-guidance-for-ph-adjuster-waiver-requests-for-generic-drugs-0001
about 1 month ago
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reposted by
Tim Sandle
Jeremy Corbyn
about 1 month ago
Solidarity is at the heart of our movement. That’s why I will always support healthcare workers in their fight to restore their pay, protect their patients and save our NHS.
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In our blood. In our water. In our babies. 🩸☠️💧Ask @EmmaReynolds to stop the poisoning of Britain, and ban
#ForeverChemicals
immediately! 🚫 Join the @38_degrees consultation submission to
#BanPFAs👇
you.38degrees.org.uk/petitions/ba...
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Let’s flood the consultation to ban these poisons!
Linked to cancer, fertility issues, and birth defects -- forever chemicals (PFAS) are now found in our food, drinking water, and even our blood. When we reach 100k signatures, 38 Degrees will submit o...
https://you.38degrees.org.uk/petitions/ban-forever-chemicals-in-the-uk?source=bluesky&utm_campaign=blast142821&utm_medium=socialshare&utm_source=bluesky&share=00d92f82-7ea8-4469-ba1f-8b5655710aa5
about 1 month ago
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What Nature Teaches Us About Leading with Seasonal Intelligence
www.pharmamicroresources.com/2025/12/what...
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What Nature Teaches Us About Leading with Seasonal Intelligence
biology, intelligence, science
https://www.pharmamicroresources.com/2025/12/what-nature-teaches-us-about-leading.html
about 2 months ago
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New bacterial therapy destroys cancer without the immune system - A research team has created an innovative cancer treatment which uses a unique microbial partnership known as AUN, forming the foundation of an immune-independent bacterial therapy:
www.pharmamicroresources.com/2025/11/new-...
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New bacterial therapy destroys cancer without the immune system
Immune system response
https://www.pharmamicroresources.com/2025/11/new-bacterial-therapy-destroys-cancer.html
about 2 months ago
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Where are the UK's start-up problem regions?
www.facilitiesmanagement-now.com/article/2357...
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Where are the UK's start-up problem regions?
Small businesses, on the start-up curve, struggle the most to survive in Rhondda Cynon Taf (Wales) over any other place in the UK, as a new study h...
https://www.facilitiesmanagement-now.com/article/235747/where-are-the-uks-startup-problem-regions
2 months ago
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A new dual-light microscope lets researchers observe micro- and nanoscale activity inside living cells without using dyes. The system captures both detailed structures and tiny moving particles at once, providing a more complete view of cellular behaviour
www.digitaljournal.com/tech-science...
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'Great Unified Microscope' reveals micro- and nano- worlds in a single view
A dual-light, label-free microscope exposes hidden micro-to-nano activity inside living cells.
https://www.digitaljournal.com/tech-science/great-unified-microscope-reveals-micro-and-nano-worlds-in-a-single-view/article
2 months ago
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Phages As A Pharmaceutical: New EMA Guidance On Antimicrobial Drug Development. Read more:
www.biosimilardevelopment.com/doc/phages-a...
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Phages As A Pharmaceutical: New EMA Guidance On Antimicrobial Drug Development
The EMA has now issued a draft guidance on quality aspects of phage therapy medicinal products. Rising antimicrobial resistance has renewed interest in bacteriophages to fight pathogens.
https://www.biosimilardevelopment.com/doc/phages-as-a-pharmaceutical-new-ema-guidance-on-antimicrobial-drug-development-0001
2 months ago
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How to risk assess isolator glove management and assess failures. See: "The weakest link? Assessing isolator glove integrity failures":
www.ejpps.online/post/the-wea...
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The weakest link? Assessing isolator glove integrity failures
Peer Review Article | Open Access | Published 13th October 2023The weakest link? Assessing isolator glove integrity failures Tim Sandle, BPL | EJPPS | 283 (2023) | https://doi.org/10.37521/ejpps.28301...
https://www.ejpps.online/post/the-weakest-link-assessing-isolator-glove-integrity-failures
2 months ago
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This week’s microbiology article, from Tim Sandle, takes a look at bacteriophages - their history and the current status of phage therapy as an alternative to antibiotics:
www.linkedin.com/pulse/bacter...
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Bacteriophages: Emerging antibacterial therapies
Bacteriophages are viruses that infect (through injection of the viral genome into the bacterial cell cytoplasm), replicate, and can kill bacteria (primarily through lysis). There are thousands of bac...
https://www.linkedin.com/pulse/bacteriophages-emerging-antibacterial-therapies-professor-tim-gra8e/
3 months ago
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Plastic-eating bacteria discovered in the ocean. Researchers at KAUST discovered that a unique molecular signature distinguishes enzymes capable of efficiently breaking down plastic:
www.pharmamicroresources.com/2025/11/plas...
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Plastic-eating bacteria discovered in the ocean
Plastic eating bacteria
https://www.pharmamicroresources.com/2025/11/plastic-eating-bacteria-discovered-in.html
3 months ago
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Free webinar - November 5, 2025, 2 p.m. (GMT) - Contamination Control Auditing for Microbiologists, with Tim Sandle.Audits can reveal hidden contamination risks if you know where to look. Learn what auditors focus on. Register here:
register.gotowebinar.com/register/277...
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https://register.gotowebinar.com/register/2775385498146326360
3 months ago
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Rising Demand for Advanced Drug Delivery Systems to Propel Pharmaceutical Packaging Market Beyond USD 299 Billion by 2035
www.pharmamicroresources.com/2025/10/risi...
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Rising Demand for Advanced Drug Delivery Systems to Propel Pharmaceutical Packaging Market Beyond USD 299 Billion by 2035
Pharmaceutical packaging market
https://www.pharmamicroresources.com/2025/10/rising-demand-for-advanced-drug.html
3 months ago
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Tim Sandle takes a look at the revision to EU & PIC/S GMP Chapter 1, providing an overview of the key changes
www.youtube.com/watch?v=9IUc...
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EU GMP Chapter 1 revision
YouTube video by Tim Sandle
https://www.youtube.com/watch?v=9IUcg2iG8B4
3 months ago
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Free webinar - Microbiology awareness: Establishing the core competencies for manufacturing personnel. Effective microbiology training is key to contamination prevention:
register.gotowebinar.com/register/720...
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https://register.gotowebinar.com/register/720271821995497559
3 months ago
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How Bamboo Products Cause a Reaction to Increase Sleep
www.pharmamicroresources.com/2025/10/how-...
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How Bamboo Products Cause a Reaction to Increase Sleep
Bambbo health products
https://www.pharmamicroresources.com/2025/10/how-bamboo-products-cause-reaction-to.html
3 months ago
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Free webinar - Join us for an engaging webinar that explores the latest advancements in automation within fill & finish processes, co-presented by industry leaders Merck, Groninger and Roche
www.pharmamicroresources.com/2025/10/from...
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From Challenges to Solutions: Enhancing Automated Environmental Monitoring in Gloveless Isolators
Merck webinar life science
https://www.pharmamicroresources.com/2025/10/from-challenges-to-solutions-enhancing.html
3 months ago
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A groundbreaking treatment that supercharges ordinary vinegar to help wounds heal faster and fight off infection has been developed
www.digitaljournal.com/tech-science...
#microbiology
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Supercharging vinegar with nanotech to create novel antimicrobial
Vinegar can kill microorganisms such as bacteria and viruses and treat yeast infections. A new compoundenhances this mechanism further.
https://www.digitaljournal.com/tech-science/supercharging-vinegar-with-nanotech-to-create-novel-antimicrobial/article
3 months ago
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EU GMP Chapter 1 revision: In this video I take a look at the revision to EU & PIC/S GMP Chapter 1, providing an overview of the key changes
www.youtube.com/watch?v=9IUc...
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EU GMP Chapter 1 revision
YouTube video by Tim Sandle
https://www.youtube.com/watch?v=9IUcg2iG8B4
3 months ago
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T Cell Engagers: Redefining Precision Therapy in Immuno-Oncology. Unlike conventional immunotherapies, which broadly stimulate or release the brakes on immune responses, T cell engagers act with surgical accuracy:
www.pharmamicroresources.com/2025/10/t-ce...
#immunology
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T Cell Engagers: Redefining Precision Therapy in Immuno-Oncology
Unconventional immunotherapy
https://www.pharmamicroresources.com/2025/10/t-cell-engagers-redefining-precision.html
4 months ago
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AI finds new antimicrobial with potential - enterololin, an antibacterial compound with targeted activity against Enterobacteriaceae species
www.digitaljournal.com/tech-science...
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AI finds new antimicrobial with potential
Algorithmic methods to antibiotic discovery are reaching a state of performance that can meaningfully influence how novel antibacterial molecules are discovered.
https://www.digitaljournal.com/tech-science/ai-finds-new-antimicrobial-with-potential/article
4 months ago
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Did you watch The Hack? I can't believe papers have gotten away with destroying lives for so long. That's why I've signed the petition, set up by Hugh Grant and other phone hacking victims, to demand fair, independent regulation. Join me:
you.38degrees.org.uk/petitions/a-...
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A Free Press, Not a Free Pass – It's Time for Fair Regulation
For too long, the UK press have bullied people, harassed grieving families, and destroyed lives, all to sell papers. We’ve all seen the heartbreaking consequences. They’ve hacked phones, listened to ...
https://you.38degrees.org.uk/petitions/a-free-press-not-a-free-pass-it-s-time-for-fair-regulation?source=bluesky&utm_campaign=blast140011&utm_medium=socialshare&utm_source=bluesky&share=898c1963-2ac8-4587-a323-e1ad175f686f
4 months ago
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This article takes a look at the myths and realities around A. flavus, from ancient Egyptian 'curses' to crop damage, ending in some positive news where the fungus is playing a role in cancer treatment:
www.linkedin.com/pulse/cursed...
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The cursed fungus: Aspergillus flavus - problem to solution?
Found in tombs like that of King Tut, Aspergillus flavus was once feared for its deadly spores. Now, the very same species could provide the basis for cancer treatment.
https://www.linkedin.com/pulse/cursed-fungus-aspergillus-flavus-problem-solution-professor-tim-odwke/?published=t
4 months ago
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Pharma Now × Pharmig proudly present this knowledge-packed session featuring two industry powerhouses: Professor Tim Sandle and Manish Bhatkar
www.youtube.com/watch?v=E6cJ...
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Microbiology Matters: Annex 1 & The Future of Contamination Control | Pharmig x Pharma Now
YouTube video by Pharma Now
https://www.youtube.com/watch?v=E6cJ3XPl_PE&t=160s
4 months ago
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The Science of Sweating During a Workout
www.pharmamicroresources.com/2025/09/the-...
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The Science of Sweating During a Workout
sweating and science
https://www.pharmamicroresources.com/2025/09/the-science-of-sweating-during-workout.html
4 months ago
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Microbiology/RMM In-Depth Focus 2025. This in-depth focus features articles on rapid microbiological methods, quality control, and using AI to read agar plates:
www.europeanpharmaceuticalreview.com/article/2651...
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Microbiology/RMM In-Depth Focus 2025
This in-depth focus features articles on rapid microbiological methods, quality control, and using AI to read agar plates.
https://www.europeanpharmaceuticalreview.com/article/265182/microbiology-rmm-in-depth-focus-2025/
4 months ago
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FDA Issues New Guidance For Clinical Trial Dosage Of Oncology Therapeutic Radiopharmaceuticals
www.clinicalleader.com/doc/fda-issu...
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FDA Issues New Guidance For Clinical Trial Dosage Of Oncology Therapeutic Radiopharmaceuticals
The FDA has issued a draft guidance titled Oncology Therapeutic Radiopharmaceuticals: Dosage Optimization During Clinical Development and is accepting public comments through October 20, 2025.
https://www.clinicalleader.com/doc/fda-issues-new-guidance-for-clinical-trial-dosage-of-oncology-therapeutic-radiopharmaceuticals-0001
4 months ago
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What to Know About Scientific Communication - At its core, the goal is to make complex findings accessible:
www.pharmamicroresources.com/2025/09/what...
#science
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What to Know About Scientific Communication
Science and communication
https://www.pharmamicroresources.com/2025/09/what-to-know-about-scientific.html
4 months ago
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Evaluating Pyrogen Contamination Risk and the Need for the MAT in Pharmaceutical Processing
www.researchgate.net/publication/...
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(PDF) Evaluating Pyrogen Contamination Risk and the Need for the MAT in Pharmaceutical Processing
PDF | Pyrogens are commonly divided into two classes: exogenous pyrogens, such as endotoxin from Gram-negative bacteria that induce fever when applied... | Find, read and cite all the research you nee...
https://www.researchgate.net/publication/351591034_Evaluating_Pyrogen_Contamination_Risk_and_the_Need_for_the_MAT_in_Pharmaceutical_Processing
4 months ago
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In this newsletter, Tim Sandle profiles the bacterium Stenotrophomonas maltophilia – a nosocomial emerging pathogen and a problem for healthcare and pharmaceutical water systems:
www.linkedin.com/pulse/ubiqui...
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https://www.linkedin.com/pulse/ubiquitous-narrow-malt-feeder-profiling-maltophilia-professor-tim-75mae/In
4 months ago
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Free webinar - What’s Lurking in the Water: Controlling Pharmaceutical Water Systems September 23rd 2-3pm:
register.gotowebinar.com/register/767...
4 months ago
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Microbiology Matters: Annex 1 & The Future of Contamination Control. In an interactive fireside chat, Professor Tim Sandle, PhD, one of the world’s leading voices in pharmaceutical microbiology, will share insights on what’s changing
www.pharmanow.live/pharma-event...
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Pharmig x Pharma Now Webinar | The Future of Contamination Control
Join Pharma Now, in partnership with Pharmig UK, for its first-ever webinar, joined by some of the biggest names in the microbiology industry. Register now for free!
https://www.pharmanow.live/pharma-events/pharmig-pharma-now-webinar-contamination-control
4 months ago
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This week’s article looks at some of the recent findings linked to biofilm formation in water distribution systems. This is with an emphasis on how biofilms are formed in relation to hydraulic conditions and what lessons can be drawn for system design:
www.linkedin.com/pulse/water-...
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Water microbiology: Hydraulics, plastics and biofilm development
Microorganisms in water systems will be found in one of four states: Planktonic cells, Initial surface attachment (not yet a biofilm), Biofilms, Cells, attached to loose deposits Biofilm development i...
https://www.linkedin.com/pulse/water-microbiology-hydraulics-plastics-biofilm-professor-tim-pnure
4 months ago
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Cleaning and disinfecting cleanrooms (video). Tim Sandle looks at cleaning and disinfecting cleanrooms, as a means of achieving contamination control:
www.youtube.com/watch?v=fqCP...
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Cleaning and disinfecting cleanrooms
YouTube video by Tim Sandle
https://www.youtube.com/watch?v=fqCPP3UHOv4
4 months ago
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Sterility, Sterilization and Sterility Assurance - introducing the second edition of Tim Sandle's new book
www.youtube.com/watch?v=yaru...
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Sterility, Sterilization and Sterility Assurance
YouTube video by Tim Sandle
https://www.youtube.com/watch?v=yaruEN8Ni1M
5 months ago
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Innovation with transparent antimicrobial coatings
www.pharmamicroresources.com/2025/08/inno...
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Innovation with transparent antimicrobial coatings
antimicrobial coatings
https://www.pharmamicroresources.com/2025/08/innovation-with-transparent.html
5 months ago
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Article: Considering the effects of different processes on bacterial spores, focusing on hydrogen peroxide. The killing mechanism is from oxidative damage to key proteins in the spore's inner membrane. But why are some spores resistant?
www.linkedin.com/pulse/bacter...
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Bacterial spore resistance: Spotlight on hydrogen peroxide
Many species of the orders Bacillales and Clostridiales form endospores. These remain dormant, and they are very resistant to decontamination and sterilization regimens.
https://www.linkedin.com/pulse/bacterial-spore-resistance-spotlight-hydrogen-professor-tim-pdwre/
5 months ago
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The Public Library Act 1850 enabled town councils to establish libraries and museums. One hundred and seventy-five years later, we’re still discovering the many benefits that public libraries offer their users.
5 months ago
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Rainfall intensity, soil saturation and snowmelt drive widespread landslide pathways, according to a new scientific study
www.digitaljournal.com/world/hydrol...
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Hydrological predictors: Identifying landslide threats
Rainfall intensity, soil saturation and snowmelt drive widespread landslide pathways, according to a new scientific study. Current methods to predict
https://www.digitaljournal.com/world/hydrological-predictors-identifying-landslide-threats/article
5 months ago
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Hoda Eldardiry, associate professor in the Department of Computer Science at Virginia Tech is working with a healthcare startup called LiteraSeed Inc. to launch a technology that bridges communication gaps between patients and their medical providers
www.digitaljournal.com/life/ai-expe...
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AI expert helps startup improve healthcare delivery
The best health services are well managed so as to achieve the core elements described above with a minimum wastage of resources.
https://www.digitaljournal.com/life/ai-expert-helps-startup-improve-healthcare-delivery/article
5 months ago
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A mysterious cosmic explosion has been traced to a massive stellar explosion. This cosmic event is showing fast X-ray transients (FXTs), which are blasts of X-rays from distant galaxies
www.digitaljournal.com/tech-science...
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Supernova’s jet is a source of fast X-ray transient
The new discovery represents the closest FXT associated with a supernova ever detected.
https://www.digitaljournal.com/tech-science/supernovas-jet-is-a-source-of-fast-x-ray-transient/article
5 months ago
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Will artificial intelligence be the salvation of humanity, a neutral force within which boundaries we will make our own destiny, or could AI destroy us?
www.digitaljournal.com/world/will-a...
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Will AI destroy humanity?
A detailed new forecast on AI progress, called AI 2027, predicts that Artificial General Intelligence (AGI) could send us on a new trajectory.
https://www.digitaljournal.com/world/will-ai-destroy-humanity/article
5 months ago
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Now available - antimicrobial action posters -
www.etsy.com/listing/1891...
6 months ago
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Scientists have developed a smart, bacteria-repelling coating based on resilin. When this substance is applied to surfaces like medical implants, scientists found that engineered resilin forms nano-droplets that physically disrupt bacterial cells
www.digitaljournal.com/tech-science...
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Science: Blocking bacterial infection with insect protein
These early results are very promising as a new way to help improve infection control in hospitals and other medical settings, but now more testing is needed to see how these coatings work against a wider range of harmful bacteria.
https://www.digitaljournal.com/tech-science/science-blocking-bacterial-infection-with-insect-protein/article
6 months ago
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Can we trust AI to deliver the best outcomes in pharmaceuticals and medicine? AI models can make basic errors when navigating ethical medical decisions. Researchers used ethical dilemmas and found AI often defaulted to intuitive but incorrect responses
www.digitaljournal.com/tech-science...
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AI's tendency to jump to conclusions poses risks in the medical context
Simple tweaks when using AI to review familiar medical cases expose blind spots that clinicians cannot afford to contend with. Is AI up for the task?
https://www.digitaljournal.com/tech-science/ais-tendency-to-jump-to-conclusions-poses-risks-in-the-medical-context/article
6 months ago
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A Humidex For The Cleanroom: Why Temperature And Humidity Control Matters
www.researchgate.net/publication/...
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(PDF) A Humidex For The Cleanroom: Why Temperature And Humidity Control Matters
PDF | Temperature and humidity control are important factors to control within the cleanroom. For pharmaceuticals and healthcare products, this relates... | Find, read and cite all the research you ne...
https://www.researchgate.net/publication/352853275_A_Humidex_For_The_Cleanroom_Why_Temperature_And_Humidity_Control_Matters
6 months ago
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