Excited to speak at the @stanforddata.bsky.social Sustainability Data Science conference today! I’ll be presenting ClimateX, our work on LLM confidence calibration in the climate science domain. 📄 Paper: arxiv.org/abs/2311.17107 💻 Code: github.com/rlacombe/Cli...

Poster time! Fantastic workshop on experimental design in AI for Science today. Paper: arxiv.org/abs/2503.17368 Workshop: edai4science.github.io

Nobel laureate talk time! With David Baker at the Stanford experimental design in AI for Science today.

🔔🔔 New bioML paper alert! 🔔🔔 We evaluate evolutionary protein structure prediction models using the geometric structure of non-canonical crosslinks from a rare class of post-translationally modified peptides. A thread. 🧵

"But you're so much more handsome than that!" – my beloved wife, when shown a Ghiblified selfie of ourselves. Right answer!! I'm swooning! 🥰🥰🥰

This is much deeper than it sounds at first. Absolute nugget of wisdom.

This is an excellent talk by @francesarnold.bsky.social at ACS this week. Worth a read! cen.acs.org/people/award...

LLMs are Farenheit 451 for digitized human knowledge. There’s something comforting knowing that the ghost of every written word will live on, for as long as we can preserve open weights, and the GPUs to bring them to life.

Chemical engineering rules everything around us. ⚗️ AI 🤖, bio 🧬, chips 💻, energy 🔋, fertilizers 🚜, materials ⛏️, space 🛰️ ... All the technologies shaping the world sit downstream from chemistry fundamentals. 👩‍🔬 Hold on to your periodic table and let's go! 🚀

Few things are more heart wrenching than a walk by a wild, pristine, remote beach at the confines of civilization… …only to find billions of tiny speckles of microplastics all over the sand, which we *know* will end up in our bodies by way of the food chain. Very sad.

1 failure per 1000 GPU•days is the going hardware MTF rate for large training runs these days. #NeurIPS2024

Craziest talk of the day so far: you can recognize which room someone stands in with embeddings of firing rate maps of their place cells neurons! #NeurIPS2024

Deep learning is chemical engineering for information: layers are process units, diffusion is transport, entropy is the loss function… Don’t believe me? Then why is the NeurIPS opening talk literally starting with the Haber Bosch process!?

Made it to #NeurIPS2024! Here until Sunday, ping me for coffee, a walk and talk, or some Tim Hortons maple glazed donuts! 🇨🇦

I used to add little incandescent light bulbs in my notes, for highlights.💡 But it’s time to decarbonize. 🔋 So now I add little LEDs! ⚡️

We can just fix things.

An analogy of the differences between bulk RNA-seq, single-cell RNA-seq, and spatial transcriptomics #multiomics2024 10/

Air pollution makes you dumb. iopscience.iop.org/article/10.1...

Engineering is the ultimate LEGO set. Piece some unit processes together, add sensors and a PCB to control them, break a few molecular bonds and train a neural net to run the whole thing, and don’t forget your economics so you can keep going. Is anything more fun than this!? 😀

Kim Stanley Robinson's "Ministry for the Future" is looking more prescient every day. www.nytimes.com/2024/11/28/c...

Causality is correlation with a story. Change my mind.

This feels likes it pulled right of the Ministry for the Future by Kim Stanley Robinson #climatechange #greenhousegas

Yesterday's heavy fog lifted through the night, and it's a beautiful sunny morning in California. 🌴🇺🇸 Happy Thanksgiving everyone! 🦃🍠🥧🙏❤️

Happy Chompsgiving!

"- Please generate a beautiful picture of a strange attractor. - Here's the visual representation of a strange attractor, blending intricate and dynamic patterns with a cosmic aesthetic. Let me know if you'd like any adjustments!" What do y'all think about ChatGPT's chaos theory art skills?

Aw that’s incredibly nice of you to say! 🥹🙏 I return the compliment, follow Ben and get a front row seat to the latest in AI for science! ⤵️

Still far from my old follower count, but seeing scientists collectively more here over the past few days has been nothing short of extraordinary. Key question: how to keep quality of interactions robust over time?

'I think'

A vertical takeoff of life science with #AI LLLMs. Publication of 10 new foundation models of Proteins, DNA, RNA, methylation, cells, and interactions, evolution, and design in the past couple of weeks! Unprecedented progress, reviewed in the new Ground Truths erictopol.substack.com/p/learning-t...

I feel like climate change can feel a bit mystical because the earth is, y’know, pretty complex as a system. But just tossing a, “CO2 is transparent to visible light but absorbs infrared light” in there just says “this isn’t that complex — climate deniers are denying /physics/…which is cringe.”

Make it work. 🧱 Make it right. ✅ Make it fast! 🚴‍♂️💨

RhoFold+, nucleotide language model for accurate 3d structure prediction of RNA, from the Wyss institute: www.nature.com/articles/s41...

This is insane: cluster representations of molecules by the *distance between their gzip-compressed strings* and you get better results than modern GNNs. 🤯 pubs.rsc.org/en/content/a...

you can just gzip things pubs.rsc.org/en/content/a...

You are the result of 3.8 billion years of evolutionary success. Act like it.

The world has already eradicated smallpox. Polio is the next disease we could eradicate. Here's how we got to where we are now, mostly thanks to the polio vaccine. From our work on Polio: ourworldindata.org/polio

Chemical engineering is the most fascinating field because mass transfers govern everything around us: 🦠 our cells are networks of enzymes 🩸 our body is a system of systems 🔋 our economy a flow of mass/energy 🌎 our planet a giant C, N, O cycle 🪐 thermo and kinetics rule the universe What else?

Proud hubby! 🥹🥰

Ladies and gentlemen, my better half! Making my heart sing and my skies always blue! 💙🦋

This feels like magic: shine a light, kill a tumor. 🤯 Cool paper on exposure to light from an organic LED to trigger apoptosis in mice.

Hi #ChemSky! 👋 We see you! Please give us a moment to get settled here.

Science 🤝 Startups “In the fell clutch of circumstance I have not winced nor cried aloud. Under the bludgeonings of chance My head is bloody but unbowed.” – William Ernest Henley

More ways to degrade PFAS! 🧪🦾

Key question in climate: will the predicted 2100 temperature asymptote curve keep decreasing, and how fast? We're still expecting +2.6ºC, but that's down from +3.6ºC a decade ago.

Wow ok, this tracks with the massive spike in activity here.

TIL that China has built more solar capacity in the last year than the US have in their entire history. The race for clean energy abundance is on! 🚀 globalenergymonitor.org/report/china...

Not a fan of social media balkanization, but it's cosmically beautiful to see a decentralized platform spawned out of the late Twitter now seizing the mandate of heaven. 🦋

Surprised by the number of folks suddenly following me here. How did y’all find me?

just setting up my bsky