Luke Chao
@lukechao.bsky.social
π€ 139
π₯ 110
π 6
Exploring membrane ultrastructure and dynamics chaolab.org
reposted by
Luke Chao
Freddy Benning
4 months ago
Out in print! Using ancestral sequence reconstruction π¦, in vivo characterization, and π¬ analysis, we identified key residues in the mitochondrial protein
#Mic60
that affect
#respiration
in
#yeast
. Since the preprint, we added some cool findings. π§΅β¬οΈ
onlinelibrary.wiley.com/doi/10.1002/...
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Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast
In eukaryotes, cellular respiration takes place in the cristae of mitochondria. The mitochondrial inner membrane protein Mic60, a core component of the mitochondrial contact site and cristae organizi...
https://onlinelibrary.wiley.com/doi/10.1002/pro.70207
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4
reposted by
Luke Chao
Freddy Benning
5 months ago
Iβm thrilled to share that I will join
@stowersinstitute.bsky.social
this fall to explore the evolution and design of bioenergetic membranes in bacteria.
add a skeleton here at some point
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8
2
reposted by
Luke Chao
Stowers Institute
5 months ago
Meet Friederike Benning, PhD, the newest Jim and Virginia Stowers Fellow! Her research dives into the complexity of energy generation in evolution to reveal how bacteria build membranes to survive in extreme environments. π¦ Learn more:
bit.ly/3SCZQiM
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Congrats Chen and colleagues (with shoutout to
@myfry.bsky.social
for connecting our labs)! JCI - SARM1 loss protects retinal ganglion cells in a mouse model of Autosomal Dominant Optic Atrophy
www.jci.org/articles/vie...
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JCI - SARM1 loss protects retinal ganglion cells in a mouse model of Autosomal Dominant Optic Atrophy
https://www.jci.org/articles/view/191315
6 months ago
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2
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reposted by
Luke Chao
Andrea Vettiger
7 months ago
It has been coming a long way... happy to share our latest work with you:
www.biorxiv.org/content/10.1...
Here, we show the importance of septal fortification by the Class A Penicillin Binding Protein, PBP1b, in E. coli and provide a molecular mechanism for this function. (1/12).
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The aPBP-type cell wall synthase PBP1b plays a specialized role in fortifying the Escherichia coli division site against osmotic rupture
A multi-protein system called the divisome promotes bacterial division. This apparatus synthesizes the peptidoglycan (PG) cell wall layer that forms the daughter cell poles and protects them from osmo...
https://www.biorxiv.org/content/10.1101/2025.04.02.646830v1
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15
8
reposted by
Luke Chao
preLights
8 months ago
A new
#preLight
has appeared! β¨π Barbora highlights a preprinted study from the Chao Lab (
@lukechao.bsky.social
) in which the structure-function relationship at the site of cellular respiration is under review. π Check it out! β¬οΈ
prelights.biologists.com/highlights/a...
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Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast - preLights
In this preprint the structure-function relationship at the site of cellular respiration is under review.
https://prelights.biologists.com/highlights/ancestral-sequence-reconstruction-of-the-mic60-mitofilin-domain-reveals-residues-supporting-respiration-in-yeast/
0
4
2
reposted by
Luke Chao
Freddy Benning
8 months ago
Great summary of our recent preprint by Barbora from
@prelights.bsky.social
.
#mitochondria
#cristae
#respiration
#asr
add a skeleton here at some point
0
4
1
www.biorxiv.org/content/10.1...
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Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast
In eukaryotes, cellular respiration takes place in the cristae of mitochondria. The mitochondrial inner membrane protein Mic60, a core component of the mitochondrial contact site and cristae organizin...
https://www.biorxiv.org/content/10.1101/2024.04.26.591372v2
9 months ago
0
2
0
reposted by
Luke Chao
Michelle Fry
about 1 year ago
Excited to share our collaborative work characterizing a pathogenic mutation in Opa1 found in ADOA patients that began when Tom Schwarz @BostonChildrens presented a seminar @MGHMolBio
biorxiv.org/content/10.1...
@lukechao.bsky.social
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Loss of SARM1 protects against retinal ganglion cell degeneration in Autosomal Dominant Optic Atrophy
Autosomal Dominant Optic Atrophy (ADOA), the most prevalent inherited optic neuropathy, leads to retinal ganglion cell (RGC) degeneration and vision loss. ADOA is primarily caused by mutations in the ...
https://biorxiv.org/content/10.1101/2024.09.30.615936v1
1
7
2
Congrats to Siva Boopathy and team:
www.sciencedirect.com/science/arti...
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Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Opa1 and Mfn2
Mitochondrial fusion requires the sequential merger of four bilayers to two. The outer-membrane solute carrier protein SLC25A46 interacts with both thβ¦
https://www.sciencedirect.com/science/article/pii/S0021925824022415
about 1 year ago
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Happy to see our work out in
@elife.bsky.social
! Lead by Tristan Bell and team.
#EVs
doi.org/10.7554/eLif...
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Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation
https://doi.org/10.7554/eLife.100061
about 1 year ago
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reposted by
Luke Chao
Freddy Benning
almost 2 years ago
How do baculoviruses protect their genome? Delighted to present our findings in print! We use cryo-EM to determine the structure of a baculoviral nucleocapsid. We show how the tiny capsid protein VP39 assembles into a giant nucleocapsid.βοΈπ¬
www.nature.com/articles/s41...
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Helical reconstruction of VP39 reveals principles for baculovirus nucleocapsid assembly - Nature Com...
Baculoviruses are used as insecticides, gene therapy tools, and protein production vectors. Here, the authors report the structure of the Autographa californica MNPV nucleocapsid and its fold conserva...
https://www.nature.com/articles/s41467-023-44596-y
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Excited to see Freddy's paper out in print!
www.nature.com/articles/s41...
almost 2 years ago
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Great way to ring in the New Year from Siva Boopathy and colleagues: Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Mfn2 and Opa1
www.biorxiv.org/content/10.1...
almost 2 years ago
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