Huge thanks to all co-authors and the inimitable @jbuenrostro.bsky.social for supporting this new direction - I got to think about evolution, engineering, chromatin biophysics, and modeling during the course of this project. For more, check out the preprint: www.biorxiv.org/content/10.1... 8/9

Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9

I am excited to work with 10x to take single-cell technologies to the next level - lots of new directions!

We have created a new DNase I- & ATAC-seq peak caller that uses an adaptive background model that controls for copy number variation & aneuploidy. It performs a per-nucleotide test (+FDR correction) and is very fast. Please try it out and give us feedback! github.com/vierstralab/...

Happy to share our new review on molecular circuits for genomic recording with @chenomics.bsky.social! Here, we present our views on the remaining challenges in the field of genomic recording for reconstructing cell-fate decisions. (1/2)

Cuts to #NIH funding don't just hurt scientists, but everyone who depends on new treatments, cures, & medical breakthroughs. Research can't thrive without strong, sustained support. Read more in this @60minutes.bsky.social segment featuring former NIH director Francis Collins: buff.ly/REjVWPc

Delighted to see this out! Fun fact: I actually started my lab @ UCSF w/ goal of understanding tRNA txn regulation, which aligned perfectly w/ @genophoria.bsky.social & Sohail! 6+ years of amazing collaboration & stellar work by Siyu, Albertas, & co & we're making real progress w/ more to come!

Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May: www.findaphd.com/phds/project... Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social). Please share 🙏 #epigenetics

Whenever my kid sees a Cybertruck she says "that's a stupid truck" and I feel like I'm succeeding at parenting

2) HyDrop-v2: with a new bead design it provides scalable and cost-effective generation of scATAC-seq atlases. With HyDrop atlases of the fly embryo and mouse cortex we show that CREsted models trained on HyDrop data are equivalent to models trained 10x atlases. www.biorxiv.org/content/10.1...

Very proud of two new preprints from the lab: 1) CREsted: to train sequence-to-function deep learning models on scATAC-seq atlases, and use them to decipher enhancer logic and design synthetic enhancers. This has been a wonderful lab-wide collaborative effort. www.biorxiv.org/content/10.1...

Proud to see so many fellow scientists and citizens standing up for science today! Every treatment option I'm able to offer my patients came to be because of careful persistent scientific inquiry. We cannot afford to be shortsighted when it comes to biomedical research. #StandUpForScience

Interesting work from the Tomkova group relating DNA hypermethylation of polycomb-repressed regions with gene upregulation. #Epigenetics #DNA_Methylation

What's happening is precisely outlined in Project 2025. Read it to understand what's coming next. None of this is a surprise. Also, I know this is extremely unnerving if u weren't expecting this. But let's not panic. Let's organize & give this the best fking fight of our lives.

Excited to have our sciMETv3 paper out today in Cell Genomics! We can produce hundreds of thousands of sibgle-cell DNA methylome libraries in a single experiment! (Plus lots more) www.cell.com/cell-genomic...

Just joined. Not sure how much I will post or follow. I have enjoyed the post-Twitter zen, but I do miss the collation of useful info and papers in the field.