Happy to share this study from the lab led by Orlaith Keenan published in mBio! Working with an outstanding collaborative team, Orlaith demonstrated that maintaining the right balance of neutrophils is key to limiting severe disease during C. difficile infection. journals.asm.org/doi/10.1128/...

Now out in AEM @asm.org! 🎉🧪 *High school student-isolated mutants 👉🏻 novel genetic causes of biofilm-associated adaptations *We learn how diversity arises quickly and is maintained *EvolvingSTEM enables scalable research in classrooms & promotes scientific literacy journals.asm.org/eprint/FBU9M...

We're hiring at NTU SBS, Singapore. Tenure-track faculty position in Biomedical Data Science (computational biology, AI in biology, bioinformatics). Great infrastructure, great place to do science. Please share. apply.ap1.interfolio.com/119013

We're hiring a Research Fellow (postdoc) in cell biology at NTU Singapore. The project sits at the intersection of host-pathogen interactions and ER stress biology: CRISPR screens, infection models, lipid peroxidation, wound healing. Apply or share 👇 ntu.wd3.myworkdayjobs.com/Careers/job/...

Frederick's @frederickreinhart.bsky.social paper on E. faecalis egress from host cells following intracellular replication is now up at #PLOS Pathogens. 😎 Check it out! dx.plos.org/10.1371/jour...

What if quorum sensing doesn’t promote biofilms - but restrains it? 🤔 New work from @harisantypas.bsky.social shows that the Fsr QS system in Enterococcus faecalis acts as a brake on biofilm formation and pathogenesis during infective endocarditis (IE). www.nature.com/articles/s41...

There's more! @frederickreinhart.bsky.social now shows Fsr quorum sensing turns on during intracellular replication, driving GelE-dependent host cell lysis/egress, a model for how intracellular “factories” become new extracellular inocula, primed for reinfection. 5/n www.biorxiv.org/content/10.6...

🧵Enterococcus faecalis is not just an extracellular organism. 🧵 A growing body of work shows it can survive + REPLICATE inside host cells, and that intracellular life may seed persistence, dissemination, and reinfection. 1/n #MMBR @asm.org journals.asm.org/doi/10.1128/...

Excited to share our first look at Enterococcus faecium infection biology: diabetic wounds are complex, and E. faecium persists despite early immune responses. In diabetic mice, it shows impaired clearance + sustained neutrophil recruitment, worsening healing.