Doudou Yu (@doudouyu.bsky.social)

Sleep, diet, and stress regulation are key to healthy aging but often decline early. We investigated how the hypothalamus, the brain's control center for these functions, changes during normal aging and in Alzheimer's disease (AD). Checkout our HypoAD story 🧵: www.biorxiv.org/content/10.1...

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HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer's disease Alterations in metabolism, stress response, sleep, circadian rhythms, and neuroendocrine processes are key features of aging and neurodegeneration. These fundamental processes are regulated by the hyp... https://www.biorxiv.org/content/10.1101/2025.10.08.681270v1