@crem-boston.bsky.social
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reposted by
Darrell Kotton
4 months ago
Announcing our latest publication, just out today @NatureComms, advancing our understanding of interstitial lung disease. Congrats to co-senior authors Drs. Jeremy Katzen and Kostas Alysandratos and their teams @Penn @CReM_Boston. Check it out here:
www.nature.com/articles/s41...
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Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models - Nature Communications
The direct contribution of aberrant epithelial cells to lung fibrosis is largely unknown. The authors use murine and human systems to identify how these cells activate fibroblasts, and how reciprocal signals cause them to enter a profibrotic state.
https://www.nature.com/articles/s41467-025-63735-1
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reposted by
Killian Hurley
6 months ago
Delighted to give a talk at the Vermont Lung Stem Cell Conference last week. Also got to visit with
@kottond.bsky.social
, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University
@crem-boston.bsky.social
#CureIPF
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reposted by
Darrell Kotton
7 months ago
Congrats @MingxiaGu and all the teams collaborating on this latest advance in stem cell and lung organoid research, just out @CellCellPress! and thanks for including our iPSCs!
www.cell.com/cell/fulltex...
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Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids
Recapitulating the concurrent development of germ layers through the co-differentiation of mesoderm and endoderm within a single spheroid enabled the generation of vascularized lung and intestinal org...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900628-2
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Congrats to our own Meenakshi Lakshminarayanan for being awarded Distinguished Staff of the Month. She is incredibly important to us!
www.bumc.bu.edu/camed/news-e...
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Meenakshi Lakshminarayanan, MBA, Named Distinguished Staff of the Month for July | Chobanian & Avedisian School of Medicine
https://www.bumc.bu.edu/camed/news-events/articles/2025/meenakshi-lakshminarayanan-mba-named-distinguished-staff-of-the-month-for-july/
7 months ago
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reposted by
Darrell Kotton
8 months ago
An amazing clinical triumph for regenerative medicine! A great example of how federal funding results in patient cures. Let’s keep these stories going, America! “World's First Patient Treated with Personalized CRISPR Therapy”
#helpisontheway
!
www.pennmedicine.org/news/news-re...
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World's First Patient Treated with Personalized CRISPR Therapy
In a historic medical breakthrough, a child diagnosed with a rare genetic disorder has been successfully treated with a customized CRISPR gene editing therapy by a team at Children’s Hospital of Phila...
https://www.pennmedicine.org/news/news-releases/2025/may/worlds-first-patient-treated-with-personalized-crispr-therapy
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🎉 Pulmonologist Darrell Kotton is BU’s Innovator of the Year:
www.bu.edu/articles/202...
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Pulmonologist Darrell Kotton Is BU’s Innovator of the Year
Regenerative medicine researcher is recognized for his work in pioneering lung disease treatments with stem cell technology and accelerating scientific discovery with open-access resources
https://www.bu.edu/articles/2025/pulmonologist-darrell-kotton-innovator-of-the-year/
9 months ago
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We are so proud of our director,
@kottond.bsky.social
, for being awarded BU’s Innovator of the Year!
9 months ago
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…and there’s more! Congrats to Dr. Todd Dowrey for receiving the Best Poster Award at the GMS Research Symposium!
@todd-dowrey.bsky.social
10 months ago
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Congrats to Dilnar Mahmut, one of our amazing trainees, for receiving the Outstanding Research Talk today at the GMS Research Symposium!
10 months ago
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Congrats to our poster award winners, Kevin and Braden, for their excellent work at the BU CTSI symposium!
10 months ago
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Today, we were treated to a great talk from Dr. Pulin Li of
@whiteheadinstitute.bsky.social
!
10 months ago
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reposted by
Darrell Kotton
11 months ago
Gene editing is here for Alpha-1! @BeamTx clinical trial results announced: "the world’s first results in patients who have had a disease-causing mutation corrected at the genetic level." @AlphaFriend
#helpisontheway
#becausescience
! Press release:
investors.beamtx.com/news-release...
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Beam Therapeutics Announces Positive Initial Data for BEAM-302 in the Phase 1/2 Trial in Alpha-1 Antitrypsin Deficiency (AATD), Demonstrating First Ever Clinical Genetic Correction of a Disease-causing Mutation | Beam Therapeutics
Single Dose of BEAM-302 Led to Durable, Dose-dependent Increases in Total and Functional Alpha-1 Antitrypsin (AAT), Production of Corrected M-AAT, and Decreases in Mutant Z-AAT in Circulation Across Initial Three Dose Levels Third Dose Level of BEAM-302 (60 mg, N=3) Achieved Mean Total AAT of
https://investors.beamtx.com/news-releases/news-release-details/beam-therapeutics-announces-positive-initial-data-beam-302-phase
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At the CReM, we will always
#standupforscience
11 months ago
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reposted by
Darrell Kotton
11 months ago
No matter who you voted for the NIH is bipartisan and is here for you. Don’t stop now, America! So many medicines and treatments on the market today began with NIH funding. And we’re just getting warmed up! Keep it going! Image below from: Bruce Levine, Ph.D. @BLLPHD
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Last week, we celebrated yet another successful thesis defense! Congrats to Dr. Liz Flores, our BSL4 expert!
11 months ago
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