Adults (average BMI 25) ate: 2 cups fruit daily or none for 8 wk (8-wk "washout period" - pretty good, all considered) Fruit (including bananas, apples, oranges, watermelon) 👉 ⬆️ some blood nutrients 👉BUT insulin resistance better without the fruit cdn.nutrition.org/article/S247...

The notion of "ultra-processed" food is so complicated, not even @fda.gov knows how to define it. There's a simpler way. Focus on the main health offenders: 👉Refined grains, sugar, and other highly processed carbs. In print today. Free online access (requires email) wapo.st/3WuPHGJ

Will targeting "ultra-processed food" in national nutrition policy make Americans (and the rest of the world) healthier? I argue there is a better way wapo.st/3WuPHGJ

In @natmed.nature.com, Mary Putt (@dbei-upenn.bsky.social), @davidludwigmd.bsky.social & Walter Willett (@hsph.harvard.edu) discuss concerns for the validity of short-term dietary crossover trials www.nature.com/articles/s41...

Target "ultra-processed foods" to tackle the chronic disease epidemic .... What could possibly go wrong? My 50 min convo with Nick Norwitz www.youtube.com/watch?v=JAPg...

When you have 50 min ... The investigative journalist Gary Taubes and I discuss the notion of ultra-processed foods, the sorry state of nutrition research ... and how we can inch toward truth when scientific paradigms collide. www.youtube.com/watch?v=PfOb...

The hotter it gets, the more sugar we consume ... mainly in the form of sugary drinks. 👉Let's find other ways to keep cool www.nature.com/articles/s41...

Should national nutrition policy target "Ultra-Processed Foods" as many advocate? I consider concerns in @nejm.org Like 'The Emperor's New Clothes' 👉We're rolling out a red carpet, but the evidence is threadbare! NEJM: www.nejm.org/doi/10.1056/... BLOG (no paywall) medium.com/@davidludwig...

Certified for 1-oar rowing today in Hellerup, Denmark (where we live part time). I don't believe I have Viking ancestors, but if I do, they would be proud. 😀

My 1-hour (40 min on 1.5 x 😀) deep dive on the diets, nutrition research, and where we go from here ... with journalist Gary Taubes, hosted by @metabolicmind.bsky.social

Debating the Carbohydrate-Insulin Model with John Speakman in Cell Metabolism. Letter-to-the-Editor (open access) authors.elsevier.com/a/1lCYr5WXUl... Reply www.cell.com/cell-metabol...

Avoid carbs to prevent malaria? Preliminary evidence suggests maybe so ... www.nature.com/articles/s42...

“Pathological” science? To solve the chronic disease epidemics, we need to get the research right. Gary Taubes on the failure of nutrition science to correct fatally flawed diet trials … and avoid these blunders in the first place.

Italian professional societies consensus report on diet and skin disease. Data are preliminary but promising: 👉Low-carb ketogenic diet may help acne, psoriasis link.springer.com/article/10.1...

NIH Nutrition Research Takes it on the Chin Gary Taubes' deep dive into the largest nutrition trial in years. #DesignedToFail uncertaintyprinciples.substack.com/p/nih-nutrit...

What diet works best to prevent obesity, diabetes, cardiovascular disease, cancer and Alzheimer’s? Answers remain elusive...But why? The problem may be rooted in poorly designed nutrition research. @davidludwigmd.bsky.social chibe.upenn.edu/news/short-t...

Designed to Fail: Why short-term diet trials cannot solve the epidemics of chronic disease. 👉New blog post (no paywall)

The effects of an intervention may take time to develop and persist after discontinuation, producing wash-in and washout effects that threaten trial validity. This article describes the nature of this bias in nutrition research as an illustrative case www.bmj.com/content/389/...

In an associated opinion piece in STAT News (www.statnews.com/2025/04/22/n...),

Designed to Fail: Why short-term diet trials cannot solve the epidemics of chronic disease. 👉New blog post (no paywall)

Designed to Fail Why short-term trials, like those in the $170M Nutrition for Precision Health initiative, cannot solve the epidemics of chronic disease. Study in BMJ with Walt Willett and Mary Putt www.bmj.com/content/389/... Opinion in @statnews.com www.statnews.com/2025/04/22/n...

Fascinating review cancer cell metabolism. Most cancer treatments harm the "host" (ie, the patient), in addition to the tumor. With knowledge of metabolism, we might be able to: 👉Attack the tumor AND 👉Support the host

Important paper on risk factors and life expectancy worldwide. Action mostly with smoking, diabetes, BP, weight. Less so with LDL chol. (Probably written by a committee: 👉"modification of smoking ... was associated with the most additional life-years free of death") www.nejm.org/doi/abs/10.1...

“Infants may consume upwards of 60 grams of added sugars per day, or the equivalent of two soft drinks per day if they are entirely formula-fed,” researchers say in the study, published yesterday [Feb. 24, 2025] in the Journal of Food Composition and Analysis. usrtk.org/healthwire/i...

Anti-depressant therapy for Danish winter. 👉Hellerup harbor, water temp 2° C

Will a Low-Carb Diet Reduce Racial & Ethnic Health Disparities? No paywall at this link:

NOON, Denmark. Circa solstice. View to the South. In case you were wondering, that moderately bright object about 10° above the horizon is ... the sun 😲

New American Diabetes Assoc guidelines for obesity in Type 2 diabetes. Once again: "500–750 kcal/day energy deficit is recommended" (hasn't this been tried for a century???) Regarding diet, "no single way is best" 👉Low-carb diets mentioned exactly ... 0 times diabetesjournals.org/care/article...

Do medical tailored meals improve T2 diabetes? Treatment group received home delivery of 12 meals weekly for 3 months + supports Meals per Am Heart Association guidelines, each with 60g carb (add snack, total daily carb = 200g) 👉"Intervention uptake was good but did not improve clinical outcomes"

N=1 experiment: Prolonged total fast, just coffee & electrolytes. Completing Day 2 of planned 6 days. Surprisingly easy so far, no hunger, good energy (15k ride no problem). Will see about longterm benefits. (Immediate benefit, no need to floss). (Do seek expert guidance if trying first time)

Lecturing in Norway. Today, lovely Trondheim. View from “Old Town” at sunset … about 2:30 pm 😱

On Diabetes in JAMA 👉GUESS the original publication date (see thread 2/2) "a consistent and great actual increase in the diabetes death rate has occurred" "the cause of ... this metabolic disorder is not apparent" "Perhaps ... the higher carbohydrate [has contributed]" 1/2

Delighted to give the opening keynote at the Novo Nordisk Foundation Metabolism in Action meeting Paradigm Clash in #Obesity Cause and Effect #carbohydrateinsulinmodel @metabolcenter.bsky.social For the full theory, see: www.nature.com/articles/s41...