Angela Casini
@medbioinorgchem.bsky.social
๐ค 1455
๐ฅ 151
๐ 108
Chemist, European, Academic
reposted by
Angela Casini
Carolyn Bertozzi
about 7 hours ago
www.statnews.com/2026/01/10/n...
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The NIH has lost its scientific integrity. So we left
โWe can no longer lend our credibility to an organization that has lost its integrity,โ write four scientists and administrators who recently resigned from the NIH.
https://www.statnews.com/2026/01/10/nih-resign-protest-four-leaders-cite-interference-censorship/
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I begin 2026 with the certainty that I will not be traveling to the US or sending my students there for conferences in these days where citizens can be targets of masked ICE officers and with the risk to be involved in dangerous (deadly) local situations. ๐ฅน
1 day ago
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I am pleased to announce a new adventure, in which we aim to tackle the challenge of crossing the BBB with radiotracers. Chimeric peptide-based radiopharmaceuticals for glioblastoma imaging and therapy by targeting mHsp70 and enhancing BBB penetration | ChemRxiv -
doi.org/10.26434/che...
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Chimeric peptide-based radiopharmaceuticals for glioblastoma imaging and therapy by targeting mHsp70 and enhancing BBB penetration
Glioblastoma (GBM) is the most aggressive form of malignant brain cancer. Here, we synthesized two chimeric peptide-based radiopharmaceuticals (Comb-1 and Comb-2) targeted to the membrane-bound form o...
https://doi.org/10.26434/chemrxiv-2026-wrz17?utm_campaign=shareaholic&utm_medium=bluesky&utm_source=socialnetwork
4 days ago
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A Gold-PROTAC Degrades the Oncogenic Tyrosine Kinase MERTK: Insights into the Degradome from a Steady-State System | ACS Chemical Biology
pubs.acs.org/doi/10.1021/...
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A Gold-PROTAC Degrades the Oncogenic Tyrosine Kinase MERTK: Insights into the Degradome from a Steady-State System
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules designed to induce the degradation of specific proteins within a cell. While most PROTACs are noncovalent interactors, covalent PROT...
https://pubs.acs.org/doi/10.1021/acschembio.5c00860
6 days ago
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10 days ago
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One of my favorite projects!! Thanks Inigo for making it alive ๐ through this nice video.
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27 days ago
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On my way back to Munich after an excellent Avogadro symposium 2025! Thanks to the organizers Lidia Armelao and Gianluca Farinola for hosting this event in Rome. It was great to meet friends like the wonderful Maria Laura Bolognesi and Silvio Aime and make new ones ๐ค๐๐ป๐๐ป๐๐ป
about 1 month ago
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Thanks to Prof Vicent Moliner for another excellent TrEnCa (Trends in enzyme catalysis) meeting in Benicassim! I have learned a lot about thermodynamics of enzymes and dynamics of transition states and beyond!! I spoke about our catalysis in cells with organometallic compounds ๐โบ๏ธ
about 2 months ago
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I am super proud of this paper fully based on in silico studies of metallacages to unravel their dynamic behavior in solution! I want to thank our collaborator Prof Alessio Gagliardi and the dream TEAM composted by Julia, Inigo, Darren and Gohar!!๐ซถ๐ซถ๐ซถ
pubs.acs.org/doi/10.1021/...
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Computational Workflow to Unravel the Structural Dynamics of Supramolecular Metallacages in Solution
The structural dynamics of self-assembled metallacages is important because it determines their function and stability in different applications involving encapsulation and release of a guest molecule...
https://pubs.acs.org/doi/10.1021/acs.jctc.5c01465
about 2 months ago
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Very grateful to Dori for coordinating this project! Happy to have give a small contribution to this extensive work. ๐ค๐ฅณ
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about 2 months ago
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A Small Molecule Drug-Based Ru(II) Polypyridine Mass-Tag for Multimodal Imaging of Tissue Samples | ACS Central Science
pubs.acs.org/doi/10.1021/...
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A Small Molecule Drug-Based Ru(II) Polypyridine Mass-Tag for Multimodal Imaging of Tissue Samples
Mass spectrometry imaging (MSI) is a powerful tool for spatially resolved multiomics analysis of tissue samples in clinical research. However, its proteomics application is still limited due to challe...
https://pubs.acs.org/doi/10.1021/acscentsci.5c01381
3 months ago
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Stay tuned for further updates on our new theranostics agents!! ๐Meanwhile I am grateful to the Teams of Prof Shigeyoshi Inoue and Prof Constantin Lapa for supporting this research through collaboration! ๐ค๐ฅ
www.nat.tum.de/en/nat/lates...
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Successful Development of New Radiotheranostics for Cancer Diagnosis and Therapy
Significant Research Progress Leads to Two Patent Applications
https://www.nat.tum.de/en/nat/latest/article/successful-development-of-new-radiotheranostics-for-cancer-diagnosis-and-therapy/
3 months ago
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Post-assembly modification of Pt(II) metallacages: an open door to medicinal applications | ChemRxiv -
doi.org/10.26434/che...
@gmalcantar.bsky.social
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Post-assembly modification of Pt(II) metallacages: an open door to medicinal applications
Metallacages (MCgs) have emerged as highly tunable modular โ multicomponent and multifunctional โ platforms with promising applications in catalysis, sensing, and medicine. Strategies for the synthesi...
https://doi.org/10.26434/chemrxiv-2025-59j0m?utm_campaign=shareaholic&utm_medium=bluesky&utm_source=socialnetwork
3 months ago
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Proud to be Italian these days when many workers are on strike in our cities and manifesting against the genocide in Gaza! particular mention to those who are blocking the trade of weapons directed to Israel in our ports! you are part of history today. โค๏ธ
3 months ago
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reposted by
Angela Casini
Royal Society of Chemistry
4 months ago
Want to discuss your latest research on imaging, biosensing and diagnostics research? Thereโs still time to join us at the Chemical Science symposium 2025 and present your work alongside peers and leading experts. Submit an abstract: rsc.li/chemscisymp2025 #ChemSky
@chemicalscience.rsc.org
#ChemSky
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Great EU COST LUCES workshop organized by Dr
@apoethig.bsky.social
and Prof
@lrraurell.bsky.social
at the CRC on supramolecular interactions and photophysical properties! Thanks for the wonderful science and discussion!
@gmalcantar.bsky.social
and Elisabeth Klaus gave excellent presentations ๐ค
4 months ago
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Thanks for this nice memory!! ๐ค
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4 months ago
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A fantastic end of the international symposium in Bioinorganic chemistry organized by Prof Ela Gumienna-Kontecka in Wroclaw!! Thanks for the wonderful time and โฆ till the next one ๐๐ค๐ฅRudi Fasan Gabriele Meloni David Giedroc Norah Barba
@borisvauzeilles.bsky.social
@giedroclab.bsky.social
4 months ago
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A great event for science and friendship ๐ค thanks to the organizers for the invite and the hospitality!
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4 months ago
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With one of my soulmates in Bioinrganic chemistry, Prof Ivana Ivanovic-Burmazovic at the 7th EuChems Inorganic Chemistry conference in Belgrade! ๐ค๐ Technical University of Munich and Ludwig-Maximilians-Universitรคt Mรผnchen rock together!! ๐
4 months ago
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The 7th EuChems Inorganic Chemistry conference is about to start in Belgrade!!! Lovely to meet Prof. Sanja Grguric-Spika again ๐ค
4 months ago
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The Fabulous 6 SMARTdrugs _ PIs Tim Witney Jason Holland Alex Poot Jordi Llop Miguel Castanho and myself in London together with one of their external advisors, Prof Kevin Brindle from Cambridge and TUM IAS fellow ๐ค๐ฅcredit to ChatGPT powered by Jordi Loop AI ๐
4 months ago
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The 2nd annual meeting of our EIC Pathfinder Open network SMARTdrugs _ is in full swing at KCL hosted by Tim Witney and featuring Jason Holland Jordi Llop Alex Poot Miguel Castanho and colleagues. All this in a sunny London ๐ Here a few pics of the evening on the terrace of the
#LIHE
4 months ago
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Kicking off the 3rd day at ISBOMC with the fantastic plenary lecture of Maria Contel
@contellab.bsky.social
on her journey through gold chemistry for anticancer drug discovery!! ๐ค I particularly loved her work on antibody-drug conjugates ๐๐ป๐๐ป๐๐ป๐๐ป๐๐ป๐๐ป
5 months ago
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What a day!!! ๐๐ค
@gmalcantar.bsky.social
@contellab.bsky.social
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5 months ago
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Excellent Start of ISBOMC in Paris! First day featuring many great presentations like the one of
@conchitagimeno.bsky.social
and get together with former PhDs and friends in organometallic chemistry! Thanks to
@gassergroup.bsky.social
and
@cariouk.bsky.social
for the organization!! ๐ค๐ฅ
5 months ago
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Proud of this new preprint on ML-assisted Computational Workflow to the Robust Modeling of Supramolecular Metallacages in Solution | ChemRxiv -
doi.org/10.26434/che...
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ML-assisted Computational Workflow to the Robust Modeling of Supramolecular Metallacages in Solution
We present here an integrated computational workflow to study the behavior of selected self-assembled [Pd2L4]4+ metallacages in explicit solvents (water and DMSO) and benchmark them for future in sili...
https://doi.org/10.26434/chemrxiv-2025-zt4jf?utm_campaign=shareaholic&utm_medium=bluesky&utm_source=socialnetwork
5 months ago
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Today is a good day for the results on organogold compounds in medicine! This paper concerns the 1st Gold-PROTAC investigated in a degradome assay developed by the group of Sam Meier-Menches! the study is in the frame of our
#UbiQancer
CRC TRR network โค๏ธ
chemrxiv.org/engage/chemr...
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A Gold-PROTAC degrades the oncogenic tyrosine kinase MERKT: insights into the degradome from a steady-state system
Targeted protein degradation is a valuable strategy to eliminate disease-relevant proteins. Among other classes, proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce the pro...
https://chemrxiv.org/engage/chemrxiv/article-details/68989f7f728bf9025edad3aa
5 months ago
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Our new toy ๐
@gmalcantar.bsky.social
@iiribarren.bsky.social
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5 months ago
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New Master student Sophia Ling starting her project on FAPi radiohybrid compounds for theranostics! ๐คโค๏ธ
5 months ago
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Interested in New Trends in Mass Spec Imaging of proteins in cancer tissues? Check this preprint out ;-) A small molecule drug-based Ru(II) polypyridine mass-tag for multimodal imaging of tissue samples | ChemRxiv -
doi.org/10.26434/che...
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A small molecule drug-based Ru(II) polypyridine mass-tag for multimodal imaging of tissue samples
Mass spectrometry imaging (MSI) is a powerful tool for spatially resolved multi-omics analysis of tissue samples in clinical research. However, its proteomics application is still limited due to chall...
https://doi.org/10.26434/chemrxiv-2025-hp7rl?utm_campaign=shareaholic&utm_medium=bluesky&utm_source=socialnetwork
5 months ago
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This! ๐
6 months ago
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Great time in Pisa at the 2025 Chemistry for the Future conference in the last few days!! And an excellent organization by the PhD students of the Department of Chemistry ๐๐ป๐๐ป๐๐ป Thanks for the invite ๐คhttps://cff.dcci.unipi.it
6 months ago
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Proud of my student Franziska Schuderer that today defended her PhD thesis achieving Magna Cum Laude for her work on BBB translocating radiotracers targeting glioblastoma. Well done Franzi!!! ๐ค๐๐ฅโค๏ธ
7 months ago
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Great to receive the visit of Prof Maria Contel
@contellab.bsky.social
and learning on her advancements on antibody/metallodrug conjugates for cancer treatment!!! We look forward to having you back next year ๐ค
7 months ago
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Check out our latest study on Pd-cages for dual-modality imaging including cool MS analysis and fancy in ovo PET imaging,
doi.org/10.1039/D5QI...
Congrats to Marike Drexler, Luisa Ronga, Ioannis Kanavos,
@gmalcantar.bsky.social
Daniela Kraus
@timwitney.bsky.social
! EIC Pathfinder
#SMARTdrugs
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Design of porous self-assembled homoleptic and heteroleptic Pd2+ cages incorporating silicon-based fluoride acceptors: the way towards nuclear imaging applications
Supramolecular self-assembly is a promising tool to develop multifunctional theranostic agents and has recently entered the field of radiochemistry. In this work, lantern-shaped [Pd2L4]4+ metallacages...
https://doi.org/10.1039/D5QI01092F
7 months ago
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This is where everything began for a real boost of my academic career as a TUM IAS fellow between 2016-19!!! Thank you for all your support and to make me part of the IAS community!
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7 months ago
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Certain days are really great ๐ค thanks Steffi Ludwig for the visit and beautiful flowers.
7 months ago
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Great to have Prof Janet Morrow as guest today! So many open questions on the host-guest chemistry of metallacages based on Fe(III) and on what makes them excellent contrast agents! โฆ But the future of self assembled imaging agents is bright ๐ค
8 months ago
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Extremely honoured to have our work on supramolecular radiopharmaceuticals highlighted in the latest news in Nature Biotechnology!!! Thank you to the EIC Pathfinder SMARTdrugs
@timwitney.bsky.social
@hollandlab.bsky.social
Alex Poot (UMCU)
@cicbiogune.bsky.social
Jordi Llop !
rdcu.be/emCW6
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Biopharma dives into tumor-seeking radioactive drugs
Nature Biotechnology - Big pharma and investors are piling into the precision radiation space as the next generation of increasingly potent targeted ฮฑ-particle therapies promises to destroy...
https://rdcu.be/emCW6
8 months ago
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At the end of a Golden conference with friends, Sophie Thomas @sophierthomas.bsky.social , Cider ๐บ and Chorizo โฆ ๐๐๐ฅ
@lrraurell.bsky.social
@conchitagimeno.bsky.social
8 months ago
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Laura
@lrraurell.bsky.social
rocking at the Gold conference 2025 ๐๐
8 months ago
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Excellent start of the Gold 2025 conference in San Sebastiรกn/ Donostia! Stay tuned if you want to know everything about gold that you always dreams of ๐
@sophierthomas.bsky.social
@reithoferlab.bsky.social
8 months ago
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It was a really great event!!! Thank you to the students for the invite to the Long Night of the Universities in Munich, where I could talk about Medicinal Inorganic Chemistry and of our EIC network SMARTdrugs _! Here a pic with students and with colleague Helge S. Stein ๐
8 months ago
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25 April, Liberation day in Italy! festa della liberazione dal Fascismo in Italia! ๐ฎ๐น This day is also dedicated to my grandfather Giovanni, a partisan!!! โค๏ธ
9 months ago
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Almost ready for the show! ๐ the Long night of the Universities is approaching ๐ค๐
gaf.fs.lmu.de/long-night-o...
9 months ago
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Happy Easter ๐ฃ๐๐ฅ
9 months ago
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reposted by
Angela Casini
Dori G Quiroga
9 months ago
www.sciencedirect.com/science/arti...
. Please enjoy Easter brake with our last contribution.
#chemistry
#chembiology
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Antiproliferative activity in breast cancer cells of PtL2: A steroid-thiosemicarbazone platinum(II) complex
Breast cancer remains one of the most diagnosed cancers in women worldwide. Metallodrugs such as cisplatin are used in advanced stages and hormone indโฆ
https://www.sciencedirect.com/science/article/pii/S0162013425001035
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A dream came true with this manuscript: we use N-heterocyclic carbene complexes to stabilise radioactive 198Au(I) for radiopharmaceutical applications! Featuring
@sophierthomas.bsky.social
Prof. Sarah Spreckelmeyer and fantastic collaborators! Happy Easter everyone ;-)
chemrxiv.org/engage/chemr...
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N-Heterocyclic Carbenes as Ligands to 198Au(I) Radiolabeled Compounds: a New Platform for Radiopharmaceutical Design
The application of Au(I) ions in pharmaceuticals, including in nuclear medicine, is limited by their instability towards reduction in vivo. The gold radionuclide 198Au with a half-life of 2.7 days emi...
https://chemrxiv.org/engage/chemrxiv/article-details/67fd4f786dde43c908e3d661
9 months ago
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Gold rocks ;-)
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9 months ago
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