Paul Coen
@coenpm.bsky.social
š¤ 207
š„ 1025
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Dad | Husband | Aging, Diabetes and Exercise Researcher | Liverpool FC | Weekend Warrior
Sharing the result of a collaboration with Kristin Stanford and team @OhioStateDHLRI: The brown fatāderived lipokine 12,13-diHOME combats age-related heart decline by inhibiting CaMKII and reducing ER stress.
doi.org/10.1038/s414...
@AdventHealthMD
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12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII - Nature Communications
Cardiovascular function declines with age. In this study, the authors show that the BAT-derived lipokine 12,13-diHOME preserves cardiac function in aged mice by attenuating pathological CaMKII activit...
https://doi.org/10.1038/s41467-025-62474-7
2 months ago
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The Study of Muscle Mobility and Aging (SOMMA) is open for enrollment!! SOMMA is a prospective, longitudinal cohort study designed to examine the biological properties of skeletal muscle that predict onset of disability or dementia in older adults. Learn more about SOMMA:
sommaonline.ucsf.edu
3 months ago
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Delighted to share a recent publication from a long standing collaboration with
@siobhanmalany.bsky.social
, Maddalena Parafati, and their outstanding team at University of Florida.
www.cell.com/stem-cell-re...
@spacex.extwitter.link
@stemcellreports.bsky.social
@adventhealth.bsky.social
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Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model
In this article, Parafati, Malany, and colleagues show that microgravity altered contractile response and slow-twitch protein levels in a lab-on-chip muscle model on the ISS. Electrical stimulation en...
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(25)00154-7
3 months ago
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We are recruiting! We have an open position for a Postdoctoral Fellow with the Aging, Exercise and Bioenergetics group at the Translational Research Institute in Orlando, Florida. If you know of an any trainees who might be interested, please let them know!
jobs.adventhealth.com/orlando-fl/r...
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Jobs | AdventHealth
https://jobs.adventhealth.com/orlando-fl/research-scientist-postdoctoral/4FDD6492BDE047DE90FEE8B2EEF37765/job/
5 months ago
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reposted by
Paul Coen
Katsu Funai
6 months ago
Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy
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Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy
Unlike healthy blood cells, AML cells reverse the ATP synthase reaction to support oxidative metabolism and resist chemotherapy.
https://www.science.org/doi/10.1126/sciadv.adu5511
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WTF! Leadership of the National Institute on Aging was apparently ādecimated,ā with deputy director Amy Kelly and scientific director Luigi Ferrucciā āone of the brightest luminaries in the world in gerontology,ā per a source ā among those fired.
www.splinter.com/bloodbath-at...
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'Bloodbath' at NIH and Elsewhere at HHS Begins
Splinter is your home for news and opinions that challenge power in our political and economic system that's becoming more unhinged each and every day.
https://www.splinter.com/bloodbath-at-nih-and-elsewhere-at-hhs-begins
6 months ago
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reposted by
Paul Coen
Paul Greenhaff
6 months ago
Clinical and humans physiology to the fore. Think about submitting your work to The Journal of Physiology.
doi.org/10.1113/jp28...
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Here comes the sun: the central role of human and clinical physiology in the era of multiāomics and interāorgan crosstalk
Click on the article title to read more.
https://doi.org/10.1113/jp288885
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