Alfredo Smiriglia
@alfredo95.bsky.social
π€ 87
π₯ 477
π 1
PostDoc, University of Florence.
reposted by
Alfredo Smiriglia
Edward Nirenberg
4 months ago
I may have underestimated how interesting STING isβ¦
www.nature.com/articles/s41...
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Cholesterol-binding motifs in STING that control endoplasmicΒ reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds - Nature Communications
Cholesterol lowering medication positively affects anti-cancer immune response, but the underpinning mechanism is not fully known. Here authors show that the effect is mediated by specific cholesterol...
https://www.nature.com/articles/s41467-024-47046-5
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reposted by
Alfredo Smiriglia
Andrea Morandi
5 months ago
.π§¬We looked for a CD44:SLC1A2 fusion in breast cancer. The data said no. Instead of shelving it, we published. π’ Now out in @SpringerNature MCB:
link.springer.com/article/10.1...
Negative results matter. Transparency matters. Proud of this one π₯³!
#OpenScience
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CD44 and SLC1A2 are commonly regulated but do not form a fusion transcript in ER+ breast cancer - Molecular and Cellular Biochemistry
Endocrine therapy (ET) is essential for managing ER+ HER2β breast cancer; however, resistance remains a significant clinical challenge. This study investigated whether CD44-SLC1A2 gene fusions, report...
https://link.springer.com/article/10.1007/s11010-025-05308-w
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reposted by
Alfredo Smiriglia
Andrea Morandi
7 months ago
@alfredo95.bsky.social
π€
add a skeleton here at some point
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reposted by
Alfredo Smiriglia
Andrea Morandi
8 months ago
π¨ π£ Our latest study out in
@springernature.com
ππ¦ππ ππ¦π’π΅π© & ππͺπ΄π¦π’π΄π¦, takes us beyond our usual cancer research comfort zone to explore how
#estrogen
influences the progression of
#MASLD
. Well done to
@alfredo95.bsky.social
and the rest of the team! π
www.nature.com/articles/s41...
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Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease - Cell Death & Disease
Cell Death & Disease - Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease
https://www.nature.com/articles/s41419-025-07331-7
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