📊 New study suggests GLP-1 receptor agonists may reduce overall cancer risk in people with obesity #GLP1 #Obesity #Oncology #medsky 🤔 Do you think it’s the weight loss, another mechanism of the drug, or a combination driving this effect? www.jwatch.org/na59176/2025...

New JAMA study: Semaglutide and tirzepatide reduce risk of heart failure hospitalization or death by >40% in patients with obesity-related HFpEF and type 2 diabetes—no meaningful difference between the two drugs. jamanetwork.com/journals/jam... #health #medicine #MedEd #MedTwitter #CardioTwitter

Crystal waters, stunning views! Lake Como is pure magic. #LakeComo #ItalyTravel #ScenicBeauty #LakesideVibes #TravelItaly #NatureLovers #italia

Six Books That Shaped My Journey: Lessons in Grit, Giving, and Moving Forward Check out: open.substack.com/pub/globalro... . . . . #LifeLessons #lifestyle #giving #motivation #meditations #Philosophy #medicine #MedEd #MedTwitter #CardioTwitter #BooksWorthReading

A brain-imaging study of people with amputated arms has upended a long-standing belief go.nature.com/3Jp9NPG

🧘‍♀️ Feeling overwhelmed by daily stress? MBSR (Mindfulness-Based Stress Reduction) is a science-backed 8-week program that teaches you to respond rather than react. open.substack.com/pub/globalro... #MBSR #Mindfulness #StressReduction #MentalHealth #Wellness #Meditation #StressManagement

Sam Altman says we're in an AI bubble but that "smart people get overexcited about a kernel of truth." www.cnbc.com/2025/08/18/o... Market correction incoming or just honest assessment? #AI #OpenAI #TechBubble #SamAltman

AI designed 2 novel antibiotics atom-by-atom to kill drug-resistant gonorrhoea & MRSA! Could this spark a #SecondGoldenAge in antibiotic discovery? How soon will AI revolutionize medicine on a global scale? 🤖💊 open.substack.com/pub/globalro... #Superbugs #AntibioticResistance #AIinMedicine

Apple’s smart-home future looks straight out of Pixar: think an iPad on an animating arm that dances, follows, and converses. How will you feel when your tech starts acting—and feeling—human? open.substack.com/pub/globalro... #SmartHome #AI #Apple #Robotics #Siri #HomeTech #artificialintelligence

Claude for Education could change how kids learn — instant feedback, deeper dives, & curiosity over memorization But here’s the question: if AI becomes a learning co-pilot, will kids still learn to think on their own? Or will not using it be a disadvantage? #AIinEducation #FutureOfLearning #EdTech

I just started a Substack: Global Rounds with Ali Darwish globalrounds.substack.com?r=26r0iz&utm... . . . . . #lifestyle #travel #health #photography #health #medicine #MedEd #MedTwitter #CardioTwitter #medicaleducation

What are your thoughts on this? I can see the logic with an Apple - Perplexity Deal. www.bloomberg.com/news/article... #ai #artificialintelligence #apple #perplexityai

A gene variant known to increase the risk of Alzheimer’s disease also makes people vulnerable to a host of other age-related brain disorders go.nature.com/4eRJcGD

Nature research paper: Eighteen million years of diverse enamel proteomes from the East African Rift go.nature.com/44JrujP

New: PURSUIT, a novel, once-daily oral molecule inhibitor, showed robust, dose-dependent effects on LDL-C and favorable safety in patients with hypercholesterolemia on moderate- or high-intensity statin treatment. bit.ly/3XG7Oe2 #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

1 in 5 adults have an Lp(a) level that is too high. Check out the infographic to learn more. bit.ly/3RxBF4F #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

New Study: Cannabis Use Substantially Increases Risk of Heart Attack 📌 MI: Sixfold 🔺 📌 Ischemic Stroke: Fourfold 🔺 📌 Heart Failure: Twofold 🔺 www.acc.org/Latest-in-Ca... #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

The 2024 Clinical Practice Guideline focuses on the evaluation and management of Chronic Kidney Disease (CKD), emphasizing early detection and comprehensive management strategies. #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

Muvalaplin safely lowers high levels of lipoprotein(a), or Lp(a), results from the phase 2 KRAKEN trial show. www.medscape.com/viewarticle/... #MedEd #MedSky #CardioSky

New Study: LAA Closure post-ablation led to: ⬇️ major bleeding vs. OAC (8.5% vs. 18.1%) Noninferior for stroke, systemic embolism & death www.nejm.org/doi/abs/10.1... #health #medicine #MedEd #MedSky #CardioSky

New 2025 US guidelines for managing ACS (STEMI and NSTE-ACS) recommend intravascular imaging with OCT or IVUS during PCI for left main or complex lesions with a class IA recommendation #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

10 simple yet powerful strategies to transform your workday and boost productivity, including morning routines, task prioritization, and minimizing distractions. #productivity #worklife #GTD

Among patients with ventricular tachycardia and ischemic cardiomyopathy, catheter ablation as an initial therapy led to a lower risk of adverse outcomes than antiarrhythmic drug therapy. Full VANISH2 trial results and Research Summary: nej.md/3Z5ECOD #MedSky #CardioSky

New BMJ guideline finds little to no benefit but potential harms for common spine injections. Recommends against most interventional procedures for chronic non-cancer spine pain. https://buff.ly/4i71SCm #health #medicine #MedEd #MedSky #CardioSky

New AHA/ACC guidelines on competitive sports for athletes with heart conditions emphasize shared decision-making, updated sports classifications, and addressing racial disparities in screening. https://buff.ly/433gDSu #health #medicine #MedEd #MedSky #CardioSky

Standardized Definitions of Changes in Kidney Function in Trials of Heart Failure https://buff.ly/4k8hmrF #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

Targeted Ganglionated Plexi Ablation With Nanoformulated Calcium Suppresses Postoperative AF Via Vagosympatholytic and Anti-Inflammatory Effects https://buff.ly/433s8cW #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

New AI models can help keep clinical guidelines up-to-date by continuously analyzing real-world data, say researchers. This could provide "hyperlocalized, up-to-date recommendations" for medical decision-making. #MedEd #MedSky #CardioSky https://buff.ly/4hZBPgt

Microplastics accumulate in the brain, 7-30x more than other organs. Levels much higher in those w/ dementia. Linked to blood clots and impaired brain blood flow. #microplastics #MedSky #CardioSky https://buff.ly/4aYwIes

Microplastics Are a Big Problem, a New Film Warns. Recent studies have detected microplastics in human bodies, raising significant health concerns about their impact on human health. #MedSky #microplastics https://buff.ly/3wQ05iS

Novel pharmacological approaches to lowering blood pressure and managing hypertension - Nature Reviews Cardiology https://buff.ly/4hz4mcR #health #medicine #MedEd #MedSky #CardioSky #medicaleducation

Have heart failure? This page has tips on managing symptoms, medications, and living better with this chronic condition. #HeartFailure #CardioSmart #health #medicine #MedEd #MedSky #CardioSky #medicaleducation https://buff.ly/3QfDEtZ

Dantrolene, a malignant hyperthermia drug, may protect against doxorubicin-induced cardiomyopathy by stabilizing ryanodine receptor 2 and preventing calcium leakage, according to a new study #health #medicine #MedEd #MedSky#CardioSky #medicaleducation https://buff.ly/4jW9n0J

STUDY: Oral glucose-lowering agents did not meet noninferiority criteria vs insulin for preventing large-for-gestational-age infants in gestational diabetes. 23.9% of infants were large with oral agents vs 19.9% with insulin. #MedEd #MedSky #medicaleducation https://buff.ly/4b06Xue

Thank you to each of my now 100 Followers!

Patient care experience worsened after private equity acquisition of US hospitals, with global measures like overall hospital rating and willingness to recommend declining over time compared to control hospitals. #MedEd #MedSky #CardioSky #medicaleducation https://buff.ly/4k8GezR

New study finds modified stent-in-stent approach superior to balloon angioplasty for treating pulmonary vein in-stent restenosis, reducing recurrence and improving exercise capacity. #health #medicine #MedEd #MedSky #CardioSky #medicaleducation https://buff.ly/42VaXtN

Moderate #aorticstenosis has multiple phenotypes: comorbidities are key drivers of adverse outcomes. This #JACCIMG cluster analysis suggests generalizations about #echofirst moderate AS may miss the key point. #MedEd #MedSky #CardioSky https://buff.ly/4hNj280

In a post-hoc analysis of the DAPA-HF and DELIVER trials, treatment with dapagliflozin enhanced four of five EQ-5D dimensions: mobility, self-care, usual activities, and anxiety/depression. #health #medicine #MedEd #MedSky #CardioSky #medicaleducation https://buff.ly/42PmRWh

Quantum computing enhances drug discovery! New hybrid model generates KRAS inhibitors, including 2 promising compounds with micromolar binding and selectivity. Quantum priors boost molecule quality vs classical methods. #health #medicine #MedEd #MedSky #medicaleducation https://buff.ly/4jLJh0o

Researchers found a spoon's worth of microplastics in human brains - what are the long-term neurological impacts? #PlasticPollution #BrainHealth #health #medicine #MedEd #MedSky #CardioSky #medicaleducation https://buff.ly/42BAw31

Microplastics are polluting our bodies. This review examines the toxicity of microplastics, including their exposure routes, distribution, and mechanisms of harm. Urgent action is needed to address this emerging health threat. #microplastics #medsky #cardiosky https://buff.ly/3CMY1LP

Tirzepatide treatment resulted in a 37% reduction in the composite risk of cardiovascular death or worsening heart failure compared to placebo, with significant improvements in health status. #health #medicine #MedEd #MedSky #CardioSky #medicaleducation https://www.nejm.org/doi/full/10.1056…

New atlas maps regional left ventricular scars in cardiomyopathies - a guide to diagnose causes beyond just ischemic heart disease. Patterns like septal fibrosis in laminopathies or apical scarring in Chagas can point to specific etiologies. #MedEd #MedSky #CardioSky https://buff.ly/3Em4C0g

New study links sugar-sweetened beverage intake to gut microbiome changes, altered metabolites, and higher diabetes risk. Suggests gut microbiome may mediate effects of sugary drinks on metabolic health. #health #medicine #MedEd #MedSky #CardioSky #medicaleducation https://buff.ly/3ClQbsD

New study in pigs shows a synbiotic (probiotic + prebiotic) can reduce heart damage in metabolic syndrome by targeting the gut-heart inflammatory axis. Targeting this gut-heart link could open new avenues for treating Heart Failure. #HeartFailure #MedEd #MedSky #CardioSky https://buff.ly/3WJeur9

Metabolic profiling of 1,520 drugs reveals hidden drug mechanisms, enabling discovery of new glucocorticoid receptor agonists and HMG-CoA reductase inhibitors. A powerful approach to expand the therapeutic potential of existing compounds. #drugdiscovery #metabolomics #MedSky https://buff.ly/3EiIwvG

The FDA has approved suzetrigine, the first non-opioid painkiller in decades. #health #medicine #MedEd #MedSky #medicaleducation https://buff.ly/40HDKiT

New RCT finds Starting hypertension treatment with a low-dose 2-pill combination was noninferior to stepped monotherapy, but neither the 2-pill nor the 3-pill strategies showed superiority in blood pressure control. #MedEd #MedSky #CardioSky https://buff.ly/40yrtxb

New review examines high out-of-pocket costs for heart failure meds & solutions to improve affordability & access. Factors:drug prices, insurance coverage, & lack of cost transparency. Upcoming policy changes may impact prescribing & affordability. #MedSky #CardioSky https://buff.ly/4geVEiI