How Not to be Seen: Predicting Unseen Enzyme Functions using Contrastive Learning https://www.biorxiv.org/content/10.64898/2026.02.23.707489v1

Call for the first 2026 round of the OBF Event Fellowship & overview of the overall round of 2025 www.open-bio.org/2026/03/05/e...

"This phosphodiesterase from E. coli has presented us with a poser. We do not know which node on the EC tree it is on. But we will soon find out." How Not to be Seen: Predicting Unseen Enzyme Functions using Contrastive Learning www.biorxiv.org/content/10.6...

I love curling. curl -X POST -L -H "Content-Type: application/json" -H "Authorization: Bearer <token>" -d '{"key":"value"}' api.example.com/data -o response.json --verbose

The AI of wordle as a grant reviewer: "This proposal isn’t one of the projects I think will be funded based on what I’ve learned from doing science".

New @kaggle.com competition, which I am happy to co-host Can you extract the metadata of mass-spec experiments from scientific papers? Thanks to the NSF National Synthesis Center for Emergence in the Molecular and Cellular Sciences (NCEMS) for sponsoring. www.kaggle.com/competitions...

very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...

You made the right choice by opting for Linux and I am proud of you for that. 🥹

We are deeply saddened to share the passing of Amos Bairoch, pioneer of bioinformatics and co-founder of SIB. His lifelong commitment for high-quality, open data transformed global research. We honour his legacy by continuing to build the future of bioinformatics.

My quote of the day For every complex problem there is an answer that is clear, simple, and wrong. H. L. Mencken

Happy There Is A Circulatory System Walking Through The Kitchen Day to all who celebrate.

Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching

Physicist Lise Meitner died on this day in 1968 just before her 90th birthday, having discovered fission, having been excluded from the Nobel Prize for her own discovery, and having paved the way for women in science anyway. This is her remarkable story: www.themarginalian.org/2016/10/27/l...

🧬The 6th Critical Assessment of protein Function Annotation #CAFA6 #CAFA is growing fast! We now have 295 participants! Join for the love of science🧬machine learning, and 🏆 💵. Please repost. #BIOINFORMATICS #machinelearning www.kaggle.com/competitions...

🧬The 6th Critical Assessment of protein Function Annotation #CAFA6 #CAFA is growing fast! We now have 295 participants! Join for the love of science🧬machine learning, and 🏆 💵. Please repost. #BIOINFORMATICS #machinelearning www.kaggle.com/competitions...

📣 Competition Launch Alert! CAFA 6: Protein Function Prediction hosted by @iastateresearch.bsky.social 🎯 Predict protein function from amino acid sequences 💰 $50,000 Prize Pool ⏰ Entry Deadline: Jan 26, 2026

We just launched the 6th Critical Assessment of protein Function Annotation: CAFA 6 on @kaggle.com CAFA is an ongoing community-driven experiment designed to evaluate computational methods for protein function prediction. www.kaggle.com/competitions...

An open letter about the recent cuts at GigaScience: www.open-bio.org/2025/09/30/2... (open for signatures until the end of October) #OpenScience #OpenData #GigaScience

The Jane Goodall Institute threatened to sue Gary Larson over this cartoon. Goodall told them not to be so stupid, sold it on a tshirt, and wrote the introduction to The Far Side Gallery 5. Absolute legend.

Unannotated translation products are widespread in model E. coli www.biorxiv.org/content/10.1...

This may be the most important paper ever published about NIH funded research. www.science.org/doi/10.1126/...

Obviously not a biochemist.

Welcome @isvm-society.bsky.social to bsky, the International Society for the Viruses of Microorganisms. Check the new look website isvm.org and become a member for free! #phagesky #microsky

Huge opportunity, Josie is amazing

The @scilifelab.se ancient DNA unit is looking for an bioinformatician placed at Uppsala University. This is a great way to be part of diverse #aDNA research projects as a staff scientist with permanent (!!) employment: www.uu.se/en/about-uu/...

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

Slightly diminish a band: Manganese Maiden

I think this should act as a cautionary tale for anyone thinking of using ChatGPT for anything even remotely important. They probably asked “PhD level” ChatGPT 5 to create this joke of a graph, and, predictably, it failed in a miserable and misleading way.

"I asked the AI" is not research. clauswilke.substack.com/p/i-asked-th...

Happy RNA Day to those who celebrate! 🧪 It’s AUG 1: the day we Met 🤓

I was today years old when I learned there is an Uncle Fester protein. Lol. www.uniprot.org/uniprotkb/F5...

For the first time since the Princeton Geniza Project began in 1986, we have published our metadata collated from over 30,000 Geniza documents and the People, Places, and histories of the Middle East and premodern Jewish communities found therein! zenodo.org/records/1583...

The #ismbeccb2025 CollaborationFest is starting 11:20. Come join us in room 2F near the coffee break lounge and hear all about our exciting projects! Thanks to @hmenager.bsky.social @dcgenomics.bsky.social @bosc.bsky.social

Damien Goutte-Gattat gave a thought-provoking talk about how to deal with ontology censorship. #BOSC2025 / #BOKR2025

@biodataganache.bsky.social is now up. VaLPAS: Leveraging variation in experimental multi-omics data to elucidate protein function. #ismbeccb2025 #ProteinFunction #bioinformatics

Me trying to breathe at ACC Liverpool #ismbeccb2025 #moreoxygenplease

Now up: Semi-Supervised Data-Integrated Feature Importance Enhances Performance and Interpretability of Biological Classification Tasks Jun Kim & @rbaltman.bsky.social #ProteinFunction #ismbeccb25 #bioinformatics

From the #BOSC2025 organising committee chat during Christine Orengo's keynote:"it was a very good idea to start BOSC with a TED talk ;)"

@nomiharris.bsky.social kicking off #BOSC2025 at #ISMBECCB2025

The 26th annual #Bioinformatics #OpenSource #Conference starts in just ONE WEEK! 🍐 If you're attending #BOSC2025 (in person or virtually), please join us on Slack for more conversation: join.slack.com/t/obf-bosc/s... (1/2)

Toughie 🐗 Animal #712 🐼 I figured it out in 13 guesses! 🟧🟨🟨🟨🟩🟩🟩🟩🟩🟩🟩🟩🟩 🔥 1 | Avg. Guesses: 11 metazooa.com #metazooa

How a hidden brain circuit fuels fibromyalgia, migraines, and PTSD www.sciencedaily.com/releases/202...

I'm worried that AI is not subject to the Cycle, will never move to the Trough of Disillusionment and simply keep training itself and us on its own slathers of low rent untruths until we happily live in an endless loop of distractions and irrelevance. www.media.mit.edu/publications...

CASP's funding woes. 😢 www.science.org/content/arti...

Sometimes, the headlines just write themselves: California fireworks warehouse catches fire and explodes The warehouse caught fire and blew up in Yolo County www.nbcnews.com/news/us-news...

PhD position: Bioinformatique appliquée à la protéomique (Centre du Recherche du CHU de Québec) bioinformatics.ca/jobs/phd-pos...

If EMBL-EBI managed data resources have ever saved you time & effort, this is your chance to give back! Fill in a 15-minute survey to help us: 🌍Demonstrate the real-world impact of our resources 🤓Understand your needs 🌟Secure continued funding Closes 16 July www.surveymonkey.com/r/QGFMBH8?ch...

❝Over four months, LLM users consistently underperformed at neural, linguistic, and behavioral levels. These results raise concerns about the long-term educational implications of LLM reliance and underscore the need for deeper inquiry into AI's role in learning.❞ arxiv.org/abs/2506.08872

"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...

I'm a co-author on this preprint, and I thought of posting something about it. But Chris beat me to it & he did a much better job than I could do. Unfortunately supprting flashy machine learning models over data is baked into our tech / academia ecosystem. 🧵👇