Tuberculous meningitis is often fatal, and current therapies need to be improved. In the HARVEST phase 3 trial, high-dose rifampin plus standard treatment was assessed. Full trial results: nej.md/49iiDsQ #MedSky #NeuroSky #IDSky

Did you miss the #IDWeek2025 session on Lassa fever? Check out our recap and more in IDWeek Daily News: www.pageturnpro.com/JHCLLC/11289...

We need more antifungals, so good to see these new data. www.thelancet.com/journals/lan...

One of the most challenging encounters in the outpatient practice of infectious diseases, summarized here wonderfully in @cidjournal.bsky.social by Drs. Advani and colleagues. Have already used this algorithm several times! doi.org/10.1093/cid/...

In CID, Michael R Hodges and colleagues evaluated fosmanogepix (FMGX) treatment in invasive mold diseases (IMDs) by Aspergillus spp. and rare molds in adults with limited treatment options. academic.oup.com/cid/advance-...

STOMP Study Interim analysis: - TPOXX (tecovirimat) showed no improvement in lesion resolution time vs placebo in adults with mild-to-moderate clade II mpox - Enrollment stopped in all study arms - Strong safety profile - Efficacy in severe cases not assessed www.globenewswire.com/news-release...

So excited to have the Donor-Derived Infection Special Edition out - thanks to Stephanie Pouch and Karen Waller for being guest editors for this special edition! onlinelibrary.wiley.com/toc/13993062...

We are so excited to welcome our new class of ID Fellows for next year – what an amazing group!!

The results of the SOT subgroup analysis of the SOLTICE Phase III RCT (Maribavir vs. IAT) are consistent with those of the overall population. > Effectiveness < Discontinuations. #TxID #IDSky #ViroSky #MedSky pubmed.ncbi.nlm.nih.gov/39613120/

For my inaugural post, Im proud to announce the publication of our Safer@Home care model. This is going to change how medicine is practiced. No need to admit pts "for IV antibiotics" anymore. Or just for IV diuresis in CHF. Or just for EtOH withdrawal. Etc. jamanetwork.com/journals/jam...

On World AIDS Day, let's remember those we've lost, support those living with HIV, and continue the fight for awareness and treatment. ❤️ #WorldAIDSDay2024 #IDSky #HIVSky @idsainfo.bsky.social @hivma.bsky.social

Just a friendly reminder that, in light of the IV fluid shortage, switching to PO antibiotics can be a safe, effective, and patient-centered option! This is because bacteria don't care how the antibiotic gets in. Take, for example, Gram-negative rod bacteremia!

Latest State-of-the-Art Review in @cidjournal.bsky.social comes from Dr. Miriam Barshak et al on ocular infections. (I had the pleasure of precepting Miriam in clinic around 20+ years ago --but who's counting! -- and she is brilliant and awesome.) @nottheogdrv.bsky.social doi.org/10.1093/cid/...

Interesting cluster report of symptomatic individuals in NYC presumed from Entamoeba disbar, likely sexually transmitted. academic.oup.com/ofid/advance...

Excellent thread by @dralicehan.bsky.social on this important paper in @cidjournal.bsky.social. Dramatic increase in cure with telehealth vs referral to local providers. Very concerning that telehealth coverage might soon be limited -- it's one of the silver linings of the pandemic. #IDSky

#TxID #IDSky #MedMyco pubmed.ncbi.nlm.nih.gov/39603983/

In this single-center retrospective study, @mularoni.bsky.social tested donors (3%) and recipients (8%) for HHV-8. Most of the donor-derived HHV-8-related disease manifested as KICS!! 🤯 On the other hand, most reactivations presented as KS. #TxID #IDSky pubmed.ncbi.nlm.nih.gov/39551265/

Donor-derived Mycoplasma and Ureaplasma infections in Lung Transplant: 18% of donors tested positive. Culture had higher positive predictive value (PPV) compared to PCR. www.sciencedirect.com/science/arti...

🌟"Today’s teaching point may end up as tomorrow’s myth." 🌟 Dr.Erin McCreary article 👇 #idquotes #idsky #medsky #AMSsky academic.oup.com/cid/article/...

We will have another pandemic. The question is not if but when. Excellent viewpoint in CID from 2 veterans of #publichealth Anthony Fauci & Greg Folkers. Speakly plainly they hold no punches reflecting on HIV & COVID. We need their wisdom esp now. A must read! #IDSky academic.oup.com/cid/advance-...

Don't you just love a good disease primer. Especially for neglected rare diseases we don't see in clinical practice on the daily. This #leprosy primer in nature reviews is great and comes with a snapshot summary that's very digestible. #IDSky #MedSky www.nature.com/articles/s41....

A systematic review of 24 randomized trials for #LongCovid www.bmj.com/content/387/... open-access No drug, diet, or device intervention has supportive evidence for efficacy. CBT, rehab provided some relief of symptoms (moderate certainty). We're still in desperate need for a validated treatment!

Inaugural article in a new section in @cidjournal.bsky.social called “Clinical Dilemmas in Infectious Diseases” led by IDMedEd superstars Daniel Minter and Varun Phadke designed to teach clinical reasoning Rewriting the Script academic.oup.com/cid/advance-... #IDSky

Tenets of Infectious Diseases: 1. Source control, source control, source control 2. Stuff sticks to metal (and other material) 3. The drug has to get in to work (GI absorption, tissue penetration, presence of walled-off collection, etc.) 4. Antibiotics should not be anxiolytics

Additionally, the updated research criteria for HOPE Act transplants are out. You have 15 days to share your thoughts on the revised criteria using the instruction in the notice! www.federalregister.gov/documents/20...