Nalle Pentinmikko
@npentinmikko.bsky.social
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Postdoctoral Fellow @ VincentLab
reposted by
Nalle Pentinmikko
about 2 months ago
2 post-doc positions open in the lab to do research on inter-organ signalling in regeneration and cancer in flies and mice.
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reposted by
Nalle Pentinmikko
KatajistoLab
3 months ago
Proudly presenting Simon’s
@simonsterson.bsky.social
paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social
www.nature.com/articles/s42...
@helsinki.fi
@metastem.bsky.social
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Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
https://www.nature.com/articles/s42255-025-01325-7
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reposted by
Nalle Pentinmikko
Johanna Englund
9 months ago
Finishing the year with 1st preprint from the lab! Together with
@katajistolab.bsky.social
and
@valerioizzi.bsky.social
we investigated the role of basement membrane protein Lama5 and found it is critical for luminal breast cancer initiation and growth
www.biorxiv.org/content/10.1...
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Tumour-derived LAMA5 is critical for tumour initiation and controls progression and phenotype in luminal breast cancer
Basement membrane (BM) supports and regulates the structural integrity, function and differentiation of epithelial tissues and protects against stromal invasion of breast cancer cells. Here we show th...
https://www.biorxiv.org/content/10.1101/2024.12.26.630367v1
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