New paper from the lab: we’re using long-read sequencing to disentangle isoform complexity at allele-specific loci 🧬💡 Here, we combine the PacBio Iso-Seq workflow with the established WhatsHap phasing approach to assign long reads to the correct allele in polymorphic F1 mouse hybrids.

Cracking the code of the non-coding genome via allele-specific genomics? Can we link non-coding elements—like lncRNAs and enhancers—to their protein-coding target genes, and in doing so, connect overlapping non-coding disease variants to their protein-coding counterparts?

Last month, we held the #EESAgeing symposium in Heidelberg and virtually. 📜 During the poster sessions 53 posters were presented and participants voted for four winners 🏆 Read our blog post to find our more about these brilliant minds and their abstracts: ➡️ https://s.embl.org/ees25-05-blog

🗞️Our June issue is live!📷 This month, we're featuring work on editing epigenetic age, somatic mutation, senescence, Alzheimer’s biomarkers and much more. Read it all here: nature.com/nataging/vol...

We are so happy to be on the cover @sarahhoelzl.bsky.social 🎉 The cover depicts the Three Fates, who manipulate the threads of life and death. The Fates are shown as three older women, unraveling the threads of the inactive X chromosome during aging. www.nature.com/nataging/vol...

Why do women experience aging-related diseases differently than men? A new study shows that with age, genes on the inactive X chromosome can reactivate – potentially influencing conditions like #dementia and #autoimmunity: go.tum.de/987255 #genetics #aging 📷 @dandergassen.bsky.social

I’m incredibly proud to share the results of our lab’s first project, leading to the exciting discovery – Aging promotes reactivation of the Barr body at distal chromosome regions – now published in @nataging.nature.com! 🔗 tinyurl.com/3jkzzy7d

Online now!✨RESEARCH: @sarahhoelzl.bsky.social et al demonstrate that aging promotes reactivation of the inactive X chromosome in mice, and catalog escape genes using multi-omics @dandergassen.bsky.social www.nature.com/articles/s43... rdcu.be/ekm0I

I am super proud to share the first Andergassen Lab preprint! Here, we introduce a new framework to decode the non-coding genome, led by the outstanding work of @hasenbeint.bsky.social and co-authors Sarah Hölzl, Stefan Engelhardt @tum.de👇🧵