Molecular Cell
@cp-molcell.bsky.social
đ€ 1345
đ„ 15
đ 591
Molecular Cell is a Cell Press journal that aims to publish the best papers in molecular biology.
pinned post!
Collaboration is essential to scientific progress. In our latest issue:
www.cell.com/molecular-ce...
, we present a focus issue centered around the theme of collaboration, to highlight and celebrate the importance of collaboration in scientific research.
1 day ago
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3
1
Mitochondria as sources and targets of cellular signaling
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Mitochondria as sources and targets of cellular signaling
Meichsner et al. review recent insights into mitochondria as dynamic signaling hubs. The authors describe how structural plasticity and interorganellar communication enable mitochondria to serve as both sources and targets of signaling, coordinating stress responses, metabolic adaptation, and innate immune pathways to safeguard cellular homeostasis.
http://dlvr.it/TQphLx
about 3 hours ago
0
0
0
Mito-nuclear communication: From cellular responses to organismal health
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Mito-nuclear communication: From cellular responses to organismal health
Mito-nuclear communication extends beyond the cell. This review explores how mitochondrial stress engages UPRmt and ISRmt signaling and scales through mitokines and neural circuits to shape systemic physiology, resilience, and aging.
http://dlvr.it/TQpXch
about 7 hours ago
0
3
1
Lysosomes as hubs of metabolic sensing and cellular homeostasis. @aakritijain24 and @RobertoZoncu highlight the mechanisms by which lysosomes integrate signals from across the cell in health and disease.
http://dlvr.it/TQpJnG
about 11 hours ago
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2
1
Why mâ¶A? An RNA surveillance model. @SchragaSchwartz and colleagues review recent findings on the interplay between RNA methylation and RNA processing machinery to propose a surveillance model for m6A.
http://dlvr.it/TQp3XV
about 15 hours ago
0
2
2
Ribosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors. @DeuerlingLab discusses how the NAC coordinates the fate of nascent proteins on the ribosome.
http://dlvr.it/TQnW4n
1 day ago
0
11
5
Epigenetic consequences of DNA damage
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Epigenetic consequences of DNA damage
DNA damage is not only a threat to genome integrity but also a driver of epigenetic regulation. This review highlights how oxidative lesions, R-loops, telomere damage, double-strand breaks, and PARP signaling create persistent chromatin and transcriptional changes that shape cell fate, aging, and disease.
http://dlvr.it/TQnLfm
1 day ago
0
4
0
Collaboration is essential to scientific progress. In our latest issue:
www.cell.com/molecular-ce...
, we present a focus issue centered around the theme of collaboration, to highlight and celebrate the importance of collaboration in scientific research.
1 day ago
1
3
1
The landscape of regulated cell death: Itâs all downhill from here
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The landscape of regulated cell death: Itâs all downhill from here
The regulated cell death pathways apoptosis, pyroptosis, and necroptosis are connected on multiple levels. To provide a novel and intuitive conceptual framework of the collaborative and complex nature of this interplay, we visualize cell death commitment as a landscape model, on which a cell can ârollâ downhill from life toward death.
http://dlvr.it/TQn6bK
1 day ago
0
1
1
Online Now: Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability Online now:
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Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability
Marmolejo et al. uncover transcription condensate dynamics at histone locus bodies across the cell cycle. These dynamics are governed by cell cycle (DDK and CDK1/2) and checkpoint (ATR-CHK1) kinases to precisely control the âon/offâ of histone gene transcription and maintain genome integrity.
http://dlvr.it/TQlvzF
2 days ago
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8
2
Online Now: Filament-mediated repurposing of toxic dITP for immunity in the Kongming system Online now:
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Filament-mediated repurposing of toxic dITP for immunity in the Kongming system
Feng et al. uncover how a bacterial immune effector, KomBC, is activated by the toxic nucleotide dITP. A preassembled filament converts sparse, non-cyclic dITP signals into cooperative NADase activation, revealing a distinct ultrasensitive immune mechanism.
http://dlvr.it/TQkxtz
3 days ago
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5
3
Online Now: Filament-driven activation of the Kongming antiviral system by deoxyinosine triphosphate Online now:
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Filament-driven activation of the Kongming antiviral system by deoxyinosine triphosphate
Recently, the Kongming system has been identified as a bacterial anti-phage defense system relied on nucleobase-modified nucleotides for immune signaling. Zhen et al. determine a series of cryo-EM structures of this system, revealing that dITP binding induces filament assembly of KomBC, which elucidats the activation mechanism of the Kongming system.
http://dlvr.it/TQkjgG
3 days ago
0
10
2
reposted by
Molecular Cell
9 days ago
Just out: new comprehensive review on signaling to make human ribosomes
@cp-molcell.bsky.social
. Can be found here
authors.elsevier.com/sd/article/S...
. Congrats to Baserga lab members Isabella Lawrence, Emily Sutton and Shivang Bhaskar @yalembb.bksy.social.
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Online Now: Lysosomes as hubs of metabolic sensing and cellular homeostasis Online now:
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Lysosomes as hubs of metabolic sensing and cellular homeostasis
Jain et al. review how lysosomes act as signaling hubs that couple nutrient export to sensing pathways controlling growth, stress responses, and organelle crosstalk. They highlight immune- and neuron-specific lysosomal programs that integrate metabolic status and organelle health to shape tissue physiology.
http://dlvr.it/TQdjDg
8 days ago
0
7
4
Online Now: Mitochondria as sources and targets of cellular signaling Online now:
loading . . .
Mitochondria as sources and targets of cellular signaling
Meichsner et al. review recent insights into mitochondria as dynamic signaling hubs. The authors describe how structural plasticity and interorganellar communication enable mitochondria to serve as both sources and targets of signaling, coordinating stress responses, metabolic adaptation, and innate immune pathways to safeguard cellular homeostasis.
http://dlvr.it/TQdSgH
9 days ago
0
3
3
Online Now: Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus Online now:
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Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus
Lawrence et al. examine how ribosome production in the eukaryotic nucleolus is coordinated by cytoplasmic processes to maintain appropriate ribosome numbers. The authors highlight regulatory inputs from cytoplasmic signaling, mitosis, and cytoplasmic organelles that converge on nucleolar function, and they discuss how disruption of these pathways contributes to human disease.
http://dlvr.it/TQcyFc
9 days ago
0
9
8
Online Now: Coordinating mRNA maturation: The U1 relay model Online now:
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Coordinating mRNA maturation: The U1 relay model
Yoon et al. provide a broad overview of how all the RNA processing steps are intimately linked to transcription and to one another. They propose a U1 relay model as a general framework for understanding the mechanism for coupling transcription and RNA processing.
http://dlvr.it/TQcp86
9 days ago
0
9
6
Online Now: Mito-nuclear communication: From cellular responses to organismal health Online now:
loading . . .
Mito-nuclear communication: From cellular responses to organismal health
Mito-nuclear communication extends beyond the cell. This review explores how mitochondrial stress engages UPRmt and ISRmt signaling and scales through mitokines and neural circuits to shape systemic physiology, resilience, and aging.
http://dlvr.it/TQcZk4
9 days ago
0
1
0
Online Now: Why mâ¶A? An RNA surveillance model Online now:
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Why mâ¶A? An RNA surveillance model
Dierks and Schwartz discuss the m6A surveillance model, proposing that m6A flags âundesirableâ intron-less RNAs (e.g., transposons) for decay. This provides a mechanism to distinguish âlegitimateâ spliced mRNAs and potentially suppress harmful RNA.
http://dlvr.it/TQcLPh
10 days ago
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14
11
Online Now: Ribosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors Online now:
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Ribosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors
How do ribosomes direct nascent chains toward folding or organelle targeting? This review outlines emerging mechanisms by which the nascent polypeptide-associated complex (NAC) decodes early signals at the ribosomal tunnel and orchestrates the selective engagement of cotranslational factors to maintain fidelity in protein biogenesis.
http://dlvr.it/TQbrSM
10 days ago
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4
1
A Heavy Chain Reaction: Unraveling loop extrusion dynamics during VDJ recombination
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A Heavy Chain Reaction: Unraveling loop extrusion dynamics during VDJ recombination
In this issue of Molecular Cell, Ollikainen et al. combine computational simulations with empirical data to reveal how the dynamics of chromatin loop extrusion at the immunoglobulin heavy chain locus enable comparable frequencies of VDJ recombination across megabases of chromatin.
http://dlvr.it/TQbhps
10 days ago
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2
1
Fin(e)-tuning ferroptosis
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Fin(e)-tuning ferroptosis
In a recent issue of Cell, Lorenz et al. report that the anti-ferroptosis protein GPX4 anchors to membranes using a unique âfin-loopâ element that is disrupted in an ultrarare human disease, decoupling enzyme activity from biological function and causing neurodegeneration.
http://dlvr.it/TQbTG0
10 days ago
0
1
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Whaling for the mechanisms of cancer resistance and long lifespans
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Whaling for the mechanisms of cancer resistance and long lifespans
Bowhead whales have the longest lifespan of all vertebrates, living over 200 years. The mechanisms responsible for their lifespan are mostly unknown. In a recent study in Nature, Firsanov et al. reveal that bowhead whales have evolved more efficient DNA-repair mechanisms.
http://dlvr.it/TQbDdg
11 days ago
0
0
0
Anchoring the acentric: How retention elements give ecDNA immortality
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Anchoring the acentric: How retention elements give ecDNA immortality
In a recent Nature article, Venkat Sankar et al. uncover ecDNA harboring specific DNA sequences called retention elements, contact regions of mitotic chromosomes that are bookmarked by transcription factors and chromatin proteins to promote coordinated inheritance. Retention elements are essential for ecDNA amplification, even in the absence of positive selection, and their silencing can lead to rapid ecDNA depletion.
http://dlvr.it/TQZlW0
11 days ago
0
4
1
EGO complex at 20: The Rag GTPase-TORC1 nutrient-sensing blueprint
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EGO complex at 20: The Rag GTPase-TORC1 nutrient-sensing blueprint
Two decades of discoveries following the identification of the EGO complex point to a conserved framework for nutrient-dependent (m)TORC1 signaling, where regulation of both the kinaseâs localization and signaling amplitude shapes the pathwayâs output.
http://dlvr.it/TQZby3
11 days ago
0
3
1
Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network
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Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network
Halim et al. show that chronic activation of the proteostasis regulator HSF1 broadens the mutational space accessible to the tumor suppressor p53. HSF1 enhances the fitness of destabilizing, dominant-negative p53 variants, suggesting that elevated proteostasis capacity can directly promote the emergence and persistence of oncogenic mutations in cancer cells.
http://dlvr.it/TQZNVp
11 days ago
0
0
0
Delineating the copy-number substructure of metastatic tumors with CopyKit
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Delineating the copy-number substructure of metastatic tumors with CopyKit
Wang et al. present CopyKit, a scalable and comprehensive toolkit for analyzing single-cell DNA copy-number data and estimating integer copy-number states with scquantum. Applied across primary and metastatic tumors, CopyKit resolves subclonal structure, reconstructs metastatic lineages, and reveals spatial heterogeneity in tumors.
http://dlvr.it/TQZ8Q9
12 days ago
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2
0
A mouse circadian proteome atlas
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A mouse circadian proteome atlas
Otobe et al. build a searchable web tool to explore spatiotemporal profiles of about 19,000 proteins across 32 tissues and brain regions, revealing circadian protein and phosphorylation rhythms in whole-cell and nuclear proteomes.
http://dlvr.it/TQYSCR
12 days ago
0
0
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IFI16 senses and protects stalled replication forks
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IFI16 senses and protects stalled replication forks
Gamble et al. demonstrate that detection of stalled replication forks by the innate immune sensor IFI16 induces an early STING-dependent pro-inflammatory cytokine response independently of cGAS and DNA damage. Furthermore, IFI16 exhibits dual functionality during replication stress by protecting stalled, remodeled replication forks from nucleolytic degradation.
http://dlvr.it/TQXkjj
13 days ago
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2
0
Capsid restructuring activates semi-conservative dsRNA transcription in cystovirus Éž6
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Capsid restructuring activates semi-conservative dsRNA transcription in cystovirus Éž6
Ilca et al. uncover how the double-stranded RNA cystovirus Éž6 activates its semi-conservative transcription inside its double-layered capsid. Using cryogenic electron microscopy and localized reconstruction, they visualize how nucleotide binding triggers shedding of the outer capsid layer, expansion of the inner layer, and assembly of a triskelion-shaped complex of the minor protein P7 at opposite poles of the spooled genome. These complexes organize the viral RNA-dependent RNA polymerases (P2) to initiate transcription, with the newly synthesized mRNA exiting through the hexameric P4 channels. The results reveal a multi-step structural transition that converts a quiescent capsid into an active transcriptional nanomachine.
http://dlvr.it/TQXBjB
14 days ago
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1
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Chromatin folding principles underlying the generation of antibody diversity
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Chromatin folding principles underlying the generation of antibody diversity
Ollikainen et al. combined biophysical simulations and experimental data to model chromatin structure and dynamics of the 3 Mb mouse Igh locus. The study reveals mechanisms of long-range genome communication and chromatin folding principles that enable antigen receptor diversity.
http://dlvr.it/TQX2vT
14 days ago
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4
1
ICAM1 mRNA entraps ILF2/ILF3 to inhibit transcription of EIF4E and global protein synthesis
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ICAM1 mRNA entraps ILF2/ILF3 to inhibit transcription of EIF4E and global protein synthesis
Jiang et al. show that ICAM1 mRNA suppresses cell proliferation, in contrast to the proteinâs pro-proliferative role in the same cell. This finding highlights mRNA functions independent of their proteins and challenges the interpretation of protein phenotypes solely on mRNA silencing or the central dogma.
http://dlvr.it/TQWqcd
14 days ago
0
2
1
CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity
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CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity
Liu et al. show that CASTOR1 and CASTOR2 bind arginine in a similar manner and form comparable homodimers. However, CASTOR1 senses low arginine levels, while CASTOR2 responds to high levels. Together, they function as dual arginine sensors, modulating mTORC1 activity by regulating GATOR2-GATOR1 interaction.
http://dlvr.it/TQWZp5
15 days ago
0
3
2
PDCD5 promotes substrate release from the TRiC complex in cilia and flagella
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PDCD5 promotes substrate release from the TRiC complex in cilia and flagella
Wei et al. present structural analyses of the PDCD5-TRiC complex in open states, revealing the involvement of PDCD5 in substrate release from the TRiC chamber.
http://dlvr.it/TQW5Zz
15 days ago
0
2
0
BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation
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BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation
Zheng et al. reveal a bromodomain-dependent role for BRD2 in transcriptional initiation and demonstrate that BRD2âs bromodomains anchor it to chromatin via MOF-acetylated histone H4K16. BRD2âs C-terminal domain facilitates interaction with RNA Pol II basal initiation factor TFIID. They also show that different BET domains have different acetyl-histone preferences.
http://dlvr.it/TQVx7b
15 days ago
0
3
1
Read our latest issue here
www.cell.com/molecular-ce...
15 days ago
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1
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reposted by
Molecular Cell
David Balchin
18 days ago
Our latest cotranslational folding story is now published
@cp-molcell.bsky.social
. Really cool (I think) new ideas about how exactly the ribosome directs folding and assembly to make sure complicated proteins mature efficiently in cells.
www.cell.com/molecular-ce...
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The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis
Large oligomeric proteins constitute a major fraction of proteomes, but are difficult to refold in vitro, raising the question of how cells direct their biogenesis. RoeselovĂĄ and Shivakumaraswamy et a...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)01021-4
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41
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RNA anti-CRISPRs deplete Cas proteins to inhibit the CRISPR-Cas system
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RNA anti-CRISPRs deplete Cas proteins to inhibit the CRISPR-Cas system
Gao et al. uncover the structural basis by which RNA anti-CRISPRs (Racrs) inhibit the type I-F CRISPR-Cas system and demonstrate that Racrs competitively divert Cas6f and Cas7f into aberrant assemblies. This sequestration blocks formation of the functional Csy surveillance complex, thereby disabling antiviral defense.
http://dlvr.it/TQVjh3
15 days ago
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0
0
Online Now: The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis Online now:
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The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis
Large oligomeric proteins constitute a major fraction of proteomes, but are difficult to refold in vitro, raising the question of how cells direct their biogenesis. RoeselovĂĄ and Shivakumaraswamy et al. show how the ribosome orchestrates efficient cotranslational folding and assembly.
http://dlvr.it/TQRc33
18 days ago
0
7
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Online Now: Molecular mechanism of MDA5 nucleation and filament formation by LGP2 Online now:
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Molecular mechanism of MDA5 nucleation and filament formation by LGP2
Kurihara et al. reveal that LGP2 binds dsRNA ends and translocates internally to nucleate MDA5 filaments. This mechanism allows MDA5 to recognize immunologically elusive short viral RNAs. The resulting heterofilament microclusters robustly trigger MAVS signaling, broadening the scope of innate immune detection.
http://dlvr.it/TQRP8r
18 days ago
0
6
1
Online Now: Epigenetic consequences of DNA damage Online now:
loading . . .
Epigenetic consequences of DNA damage
DNA damage is not only a threat to genome integrity but also a driver of epigenetic regulation. This review highlights how oxidative lesions, R-loops, telomere damage, double-strand breaks, and PARP signaling create persistent chromatin and transcriptional changes that shape cell fate, aging, and disease.
http://dlvr.it/TQMvYV
22 days ago
0
4
0
Online Now: Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network Online now:
loading . . .
Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network
Halim et al. show that chronic activation of the proteostasis regulator HSF1 broadens the mutational space accessible to the tumor suppressor p53. HSF1 enhances the fitness of destabilizing, dominant-negative p53 variants, suggesting that elevated proteostasis capacity can directly promote the emergence and persistence of oncogenic mutations in cancer cells.
http://dlvr.it/TQMgmG
22 days ago
0
1
0
Online Now: Delineating the copy-number substructure of metastatic tumors with CopyKit Online now:
loading . . .
Delineating the copy-number substructure of metastatic tumors with CopyKit
Wang et al. present CopyKit, a scalable and comprehensive toolkit for analyzing single-cell DNA copy-number data and estimating integer copy-number states with scquantum. Applied across primary and metastatic tumors, CopyKit resolves subclonal structure, reconstructs metastatic lineages, and reveals spatial heterogeneity in tumors.
http://dlvr.it/TQMQhp
23 days ago
0
2
0
Online Now: A mouse circadian proteome atlas Online now:
loading . . .
A mouse circadian proteome atlas
Otobe et al. build a searchable web tool to explore spatiotemporal profiles of about 19,000 proteins across 32 tissues and brain regions, revealing circadian protein and phosphorylation rhythms in whole-cell and nuclear proteomes.
http://dlvr.it/TQLxF5
23 days ago
0
2
0
This ribosome goes to 11
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This ribosome goes to 11
In this issue of Molecular Cell, Ishiguro et al.1 describe new RNA modifications near the active site of the E. coli ribosome that appear only under anaerobic conditions. These modifications enhance ribosome activity and increase anaerobic growth rates.
http://dlvr.it/TQLmmX
23 days ago
0
2
2
Finding an Achillesâ heel of cancer cells: Exonized Alu elements in AURKA
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Finding an Achillesâ heel of cancer cells: Exonized Alu elements in AURKA
In this issue of Molecular Cell, Kral et al. identify a targetable, novel mechanism of pancreatic ductal adenocarcinoma (PDAC) tumorigenesis via SRSF1 splicing-mediated regulation of an Alu-derived exon in Aurora kinase A (AURKA).
http://dlvr.it/TQLXpG
23 days ago
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1
0
Donât forget protein synthesis! Mitochondria of cancer cells import glutamine to fuel metabolism and to charge tRNAs for translation
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Donât forget protein synthesis! Mitochondria of cancer cells import glutamine to fuel metabolism and to charge tRNAs for translation
In this issue of Molecular Cell, Zhu et al.1 show that mitochondria of cancer cells rely on the import of glutamine not only to fuel metabolite synthesis via the tricarbonic acid cycle but also to charge tRNA (Gln) to allow mitochondrial protein synthesis and respiration.
http://dlvr.it/TQLJKK
24 days ago
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4
1
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains
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Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains
Guo et al. elucidate short RNA chaperones that prevent and reverse toxic cytoplasmic aggregation of the prion-like, ALS/FTD-linked proteins FUS and TDP-43. By restoring the nuclear localization of FUS and TDP-43, these short RNAs provide a foundation for RNA-based therapeutics targeting TDP-43 and FUS proteinopathies in neurodegenerative disease.
http://dlvr.it/TQKpjJ
24 days ago
0
2
0
Membrane-protein-mediated phase separation orchestrates organelle contact sites
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Membrane-protein-mediated phase separation orchestrates organelle contact sites
Hoffmann, Nagao, et al. show that PDZD8, an endoplasmic reticulum (ER) membrane contact site protein, forms liquid-like condensates through its intrinsically disordered region. These condensates mediate stable adhesion between the ER and other organelles, such as mitochondria and lysosomes, enabling molecular exchange and orchestrating inter-organelle communication and structural integrity.
http://dlvr.it/TQKfhq
24 days ago
0
2
1
How does cytoplasmic crowding affect reaction rates?
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How does cytoplasmic crowding affect reaction rates?
Theory shows that the crowded nature of the cytoplasm might speed up enzyme-mediated reactions by entropically promoting the formation of enzyme-substrate complexes or slow reactions down by impeding diffusion. Recent studies of enzyme rates in cells and cytoplasmic extracts provide little support for the former. It appears that crowding generally decreases reaction rate constants in vivo.
http://dlvr.it/TQKQfD
24 days ago
0
2
1
RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria
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RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria
This study introduces CRASP-seq, an RNA-coupled CRISPR screening platform designed to systematically identify regulatory factors and domains of alternative pre-mRNA splicing. Using this technology, ZNF207 is identified as a bona fide splicing regulator through its interaction with U1 snRNP components. ZNF207 modulates aberrant LMNA splicing, a critical event linked to progeria.
http://dlvr.it/TQKBHt
25 days ago
0
1
0
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