Med News: Even as #GLP-1 medications have shifted #obesity care, physical activity continues to provide #cardiometabolic benefits, @americanheart.bsky.social emphasizes in a new scientific statement.

Med News: Novel #GLP-1 drugs and other incretin-based therapies for #diabetes and weight loss took center stage at #ADA2026. Learn about the latest data in this interview with Rita Kalyani, MD, chief scientific and medical officer @amdiabetesassn.bsky.social.

"Something about these goals rang hollow even when I met them." In #APieceofMyMind, a retired internal medicine physician examines the role of quantification, trade-offs, and relinquishment. ja.ma/4uJstvw

💡 JAMA Insights: #Vibriosis refers to infection by noncholera Vibrio species found in US coastal waters. Transmission occurs through consumption of contaminated seafood or exposure of wounds to marine water. ja.ma/4xzELsV

🤖 JAMA+ AI Conversations: Yun Liu, PhD, discusses whether the promise of #AI in #medical imaging depends on accuracy alone or if #clinical value hinges on how results are presented and their impact on behavior and decision-making.

Federal funding helped prevent a surge in nursing home closures during COVID-19, but nearly 29% of closures left residents without access to nearby care, especially in rural areas. ja.ma/4aVwuFP

💬 Healthy Dialogue: Early-onset #ColorectalCancer is rising among young adults, now the leading cause of #cancer death in this group. 🎧 Listen now: ja.ma/4a9yeuR

Among patients with EGFR-variant nonsquamous #NSCLC whose disease progressed after prior EGFR tyrosine kinase inhibitor therapy, the addition of ivonescimab to #chemotherapy improved overall survival compared with chemotherapy alone. ja.ma/4a9vgXf

In infants with moderate to severe #Bronchiolitis on high-flow nasal cannula, prone positioning did not significantly reduce escalation to noninvasive or invasive ventilation compared with supine. #ESPNIC2026 @espnic.bsky.social ja.ma/4ervCtv

📢 Calling all early‑career faculty The JAMA Network is accepting applications for two editorial training programs designed to build your peer review and editorial skills. 🔗 Decide which is the best fit for you: ja.ma/4umJYRX

🗣️ New viewpoint in @jama.com led by @piatkowskitim.bsky.social! 💉 Illicit injectable peptides are increasingly promoted online for enhancement, raising concerns about youth exposure, limited safety evidence, and regulatory gaps. 🔗 Read here: tinyurl.com/jamapeptides

📌 Editor’s Choice from this week's issue of JAMA: ➡️ Digitalis Glycosides Effective for #HFmrEF, ➡️ Digoxin for Rheumatic #Heart #Disease, ➡️ Healthy Dialogue on #Dementia's New Era, and more. ja.ma/4vRti6k

Stillbirth involves the death of a fetus about halfway through #pregnancy or later or with a birth weight of at least 350 g. 📄 This JAMA Patient Page describes the causes, risk factors, and methods for evaluating #stillbirth before and after it occurs. ja.ma/49YEdmf

📣 Special Communication: Pooling public and private payments into a statewide #PrimaryCare fund could improve access, streamline practice revenues, and support continuity for patients changing insurers. ja.ma/4uBYrcK

Meta-analysis of digitalis glycosides in HFmrEF or HFrEF indicated reduced risk of worsening #HeartFailure events, with no difference in mortality, across multiple randomized trials. ja.ma/4xwtlGm

In patients with symptomatic #RheumaticHeartDisease, digoxin reduced the risk of a composite of all-cause death or new-onset or worsening #HeartFailure compared with placebo, with little risk of toxicity. ja.ma/43C1ve4

💬 Editorial: Screening for presymptomatic #Type1Diabetes in children is feasible and identifies early-stage disease regardless of family history, supporting expansion of population screening and early intervention. ja.ma/4xDdDt9

General population islet autoantibody screening identified early-stage #Type1Diabetes in children, with similar progression rates to clinical disease regardless of family history, supporting broader screening initiatives. ja.ma/4uyooKl

Medicare-funded residency expansions from 2021 and 2023 Acts prioritized health professional shortage areas and psychiatry, but rural and primary care position targets were not met. #MedicareGME #PrimaryCare ja.ma/4enJKnF

#AI-enabled optical coherence tomography demonstrated high sensitivity and specificity in #DiabeticMacularEdema screening and reduced unnecessary referrals in patients with #diabetes. ja.ma/4ecEJ2r

In this JAMA Clinical Reviews podcast, JAMA Deputy Editor Mary McDermott, MD, interviewed James McAuley, PhD, Professor of Medicine and Health at the University of New South Wales, about the diagnosis and management of nonspecific low back pain. 🎧 Listen now: ja.ma/4vOGokE

💬 Viewpoint: Synthetic injectable peptides promoted for muscle growth, recovery, and antiaging are increasingly accessed by young people online, while regulatory and clinical oversight remain limited. #Peptides #DigitalHealth #YouthExposure ja.ma/43xHS6W

Medicare-funded residency expansions from 2021 and 2023 Acts prioritized health professional shortage areas and psychiatry, but rural and primary care position targets were not met. #MedicareGME #PrimaryCare ja.ma/4uCSlca

💬 Editorial: Intensive lifestyle interventions in the US Diabetes Prevention Program reduced multimorbidity risk and improved quality of life among adults with prediabetes, supporting preventive strategies for #Diabetes. ja.ma/4vTjAR1

Lifestyle intervention was associated with lower multimorbidity burden than placebo, while #metformin showed no difference, among older adults with prediabetes followed for 21 years. #Diabetes #Multimorbidity ja.ma/4a2ZMSD

#AI-enabled optical coherence tomography demonstrated high sensitivity and specificity in #DiabeticMacularEdema screening and reduced unnecessary referrals in patients with #diabetes. ja.ma/4ex29yG

3 new papers on Covid boosters today 1. Less major adverse cardiovascular events in US Veterans jamanetwork.com/journals/jam... 2. High effectiveness for older adults jamanetwork.com/journals/jam... 3. Improved outcomes across all adults jamanetwork.com/journals/jam...

Low back pain is defined as pain located below the costal margin and above the inferior gluteal folds, with or without leg pain and is the leading cause of years lived with disability worldwide, affecting people of all ages. Learn more in this Review: ja.ma/3SbmHVN

The JAMA Network is accepting applications for two training programs designed to support early‑career researchers interested in scholarly publishing. ✍️ Peer Review Academy 📚 Editorial Fellowship Learn more about both and apply now: ja.ma/49PNAoa

This JAMA Insights describes 3 essential strategies for #surgeons: attending to emotion, using scenario planning, and describing goals and downsides. Improving these skills can enhance trust and strengthen patient-centered care. ja.ma/4eFMtdr

"In the past 20 years, there's tremendous increased prevalence of obesity, not only in China, but also globally, especially in young population." Linong Ji, MD, shares his perspective while attending the #JAMASummit on #Obesity.

JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, Deputy Editor Linda Brubaker, MD, and Associate Editor Christopher W. Seymour, MD, MSc, discussed the latest published: ➡️ JAMA at #CCR26, ➡️ #Insulin Cost Caps for #Medicare Beneficiaries, and more. ja.ma/3QBXVxC

In this observational study of adults in Stockholm, measured GFR (mGFR) values below 90 mL/min/1.73 m² were associated with progressively higher rates of #mortality, #kidney failure, #heart failure, acute kidney injury, and major #cardiovascular events. ja.ma/4aNjKky

Among adolescents in the Adolescent Brain Cognitive Development Study, increasing #SocialMedia use was associated with modestly reduced cognitive performance on multiple NIH Toolbox assessments, including reading recognition, episodic memory, and vocabulary. ja.ma/4vDyoCU

A potential #fentanyl vaccine has entered human trials for the first time, offering new hope in addressing the ongoing opioid crisis. Jennifer Abbasi and Kate Schweitzer discuss how the investigational vaccine works and more. 🎧 Listen: ja.ma/3QAm5Zn

💬 Perspective: The #ACCESS model introduces Outcome-Aligned Payments that reward clinical improvement in technology-enabled chronic disease care, supporting flexible, integrated delivery for #Medicare. ja.ma/4egevwd

📊 Research Summary: A parental support package including mentorship, virtual support, breast pump, and bassinet reduced burnout and relationship strain among pregnant physician trainees. ja.ma/4e8zAZo

“Equitable access is something that is a global imperative of our community, is something that we need to engage and commit to, to make sure that this big public health crisis finally comes to an end.” Francesca Celletti, MD, PhD, shares her perspective while attending the #JAMASummit on #Obesity.

Med News: A fentanyl vaccine is now in human trials. If proven safe and effective, it would be the first proactive pharmaceutical to prevent overdose and support addiction treatment. Learn more about the research and its public health potential:

💬 Viewpoint: The FY 2027 proposal to dissolve HRSA risks disrupting the J-1 visa waiver pipeline essential for international medical graduates (#IMGs). This change could impede physician recruitment for underserved rural and urban US communities. ja.ma/3Q0sgWu

💬 Editorial: One in four residency and fellowship programs lack written parental support policies. Enhanced, individualized support can address burnout and mental health challenges during medical training. ja.ma/4on98yt

RCT: A parental support package including tangible and mentorship components was associated with less postpartum burnout and improved well-being among pregnant medical trainees. ja.ma/4eoLZax

Among adults undergoing emergency #laparotomy, routine use of incisional negative pressure wound therapy did not significantly decrease surgical site infection or improve secondary outcomes such as #hospital readmission, wound pain, or quality of life. ja.ma/4uPebKn

📊 Research Summary: In critically ill children, omitting routine #GRV measurement did not affect survival or ventilator-free days and improved nutritional target achievement, supporting deimplementation. #CCR26 @criticalcarereviews.com ja.ma/4emRvdG

💬 Editorial: The GASTRIC-PICU trial found no benefit from routine gastric residual volume assessment in ventilated children, consistent with current recommendations to avoid the practice. #CCR26 @criticalcarereviews.com ja.ma/449Tf53

Withholding routine gastric residual volume (#GRV) assessments in ventilated children was noninferior for survival and ventilator-free days, while improving early nutrition and causing no increase in complications. #CCR26 @criticalcarereviews.com ja.ma/3QjwKHM

#CCR26 BIHCA trial, RESULTS! 88% patients had non-shockable initial rhythm. 8 mins to trial drug!! 70% patients received 2 drug doses. PRIMARY O: Bicarb 39% vs. placebo 37%; RR 1.05 [0.88, 1.24]; p = 0.62 2° O: No statistical difference in survival (30/90d). Results in @jama.com

Hearing aids are small electronic devices that fit into the ears and amplify sounds for individuals with hearing loss. It is projected that by 2030, about 35 million adults in the US will have mild hearing loss. 📝 Learn more in this Patient Page: ja.ma/4eEqhzt

"I start typing, and I sign one of my morning charts. I take a bite. Sign a chart. Take a bite. And so it goes, every day. I type and I type." In #APieceofMyMind, a #pediatrician takes a short walk to find respite in the beauty of nature. ja.ma/4getzLT

💬 Viewpoint: Uploading a full #EHR to commercial #AI chatbots may improve access but exposes #patients to #privacy risks, amplifies #clinical biases, and grants companies wide latitude over #medical data use outside #HIPAA protections. ja.ma/4v2nJBX