Excited to share our latest collaborative study of a frontier approach in cancer immunotherapy, targeting the Nonsense-Mediated mRNA Decay (NMD) pathway. Read more in a short 🧵+ link to preprint is below:

📣 Attention postdocs in the life sciences! Are you ready to take the big leap? Start your lab at the Biotech Research and Innovation Centre in Copenhagen! 🇩🇰 @bric-ucph.bsky.social Collegial atmosphere, cutting-edge science, core funding. (+the weather is wonderful, relative to Siberia😁) Apply!👇

Congrats to colleagues from IRB!

🛑Guille's @guillepalou.bsky.social no-nonsense 😉 paper is out in @springernature.com Genome Biology! We report variable activity of the NMD pathway (mRNA QC) across tissues & individuals: 🧠less active in the nervous system & in reproductive tissues 🩸more active in digestive tract, muscle, blood

Fantastic to be in such great company!🤩 👏Congrats to 19 colleagues from my institutions (🇩🇰BRIC @UCPH_health and 🇪🇸@IRBBarcelona) in this year's Elsevier/Stanford top 2% most cited researchers list

Thanks to organizers for inviting!

🧬New approach to decoding mutational signatures improves prediction of prognosis in #OvarianCancer. 📰 #GenomeMedicine ✍️ Patricia Ferrer-T Iván Galván-F & @fransupek.bsky.social ➡️ bit.ly/4nA579b 📌DOI: 10.1186/s13073-025-01497-7 @genomedatalab.bsky.social @bric-ucph.bsky.social 🧪

Congrats to our CRISPy fresh doctor 👏👏 Marcel McCullough for successfully defending his PhD thesis: 🧬✂️"Combinatorial Gene Editing in Human Cells to Model Deficiencies of DNA Repair in Cancer" Thx to committee members Julian Ceron, Laura Valle and David Szuts for a great discussion!

Join us at BRIC/FinsenLab -- start your group at the University of Copenhagen!

🧵 Ahmed’s @genomedatalab.bsky.social paper on evolution of chemotherapy resistance is out @natcomms.nature.com! We developed DiffInvex - a method tracking how #cancer driver genes change under therapy using ~10k whole-genomes. Key insight: drug resistance often emerges through existing pathways 1/5

Great news – we received funding from the Independent Research Fund Denmark (DFF)! 🧬We will study #cancer driver mutations in tumor suppressor genes. In particular, we will focus on so-called "dominant negative" mutations, by combining #genomics, #AI & CRISPR gene editing.