@evisoutoglou.bsky.social
📤 291
📥 281
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reposted by
Di Jiang
about 1 month ago
@science.org
🧬Cohesin guides homology search during DNA repair using loops and sister chromatid linkages | Science
www.science.org/doi/10.1126/...
@fedeteloni.bsky.social
@danielgerlich.bsky.social
et al.
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Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
https://www.science.org/doi/10.1126/science.adw0566
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reposted by
Pablo Huertas’ lab
about 1 month ago
Finally published! Our work on how the
#CircadianClock
controls DNA repair. This has direct implications for cancer treatment:
#Chronotherapy
. @CABIMER @UniSevilla
rdcu.be/eSwxl
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Circadian regulation of homologous recombination by cryptochrome1-mediated dampening of DNA end resection
Nature Communications - The study shows that DNA double-strand break repair follows a circadian rhythm: homologous recombination peaks in the morning and declines by evening. CRY1 regulates CCAR2...
https://rdcu.be/eSwxl
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reposted by
Diana Rubio-Contreras
about 1 month ago
Excited to see our research published!! 🎉 Amazing project in
@fgh-lab.bsky.social
at
@ibis-investigacion.bsky.social
"H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death"
www.nature.com/articles/s41...
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reposted by
Kerstin BYSTRICKY
about 1 year ago
Out now in @ScienceAdvances 👇
science.org/doi/10.1126/...
BRAVO @tomsexton_lab and super help from
@tinekelenstra.bsky.social
@mitchell_lab
@akispapantonis.bsky.social
@molina_lab
@evisoutoglou.bsky.social
@NeoVirTech
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Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics
Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.
https://science.org/doi/10.1126/sciadv.adq0987
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reposted by
Akis (Argyris) Papantonis
about 1 year ago
…a real team effort with
@kerstinbys.bsky.social
,
@tinekelenstra.bsky.social
,
@evisoutoglou.bsky.social
, Jennifer Mitchell, Nacho Molina.
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Happy to join the scientific community in this forum!
about 1 year ago
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