Synapticure (@synapticure.bsky.social)

Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology In this article, de Majo et al. present a novel 3D iPSC-derived model to study neurodegenerativedisorders such as ALS and FTD. When devoid of GRN expression, these cultures presentfeatures of ALS- and FTD-associated pathology hardly ever observed in vitro. Thesephenotypes are shown to be primarily driven by diseased astrocytes and can be rescuedby pro-granulin supplementation. https://www.cell.com/stem-cell-reports/fulltext/S2213-6711%2823%2900015-2