Hi #ScienceSky people, back with #PeerOnSky series! After discussing reporting bias, let’s dive into a topic that’s currently reshaping regulatory landscapes and drug development: External Controlled Trials (ECT). Ever heard of "Synthetic Controls" or "Historical Controls"? Let’s break it down!

This paper is fully aligned with the themes of our @sharectd.bsky.social doctoral network featuring stellar PhD students (such as @kahin-tai.bsky.social and @giulia-varvar.bsky.social with whom we have published several nice papers on data sharing). a) www.jclinepi.com/article/S089...

@kahin-tai.bsky.social's excellent talk (delivered as part of the LORIER Webinar Series on Reproducibility and Meta-Research, in partnership with @sharectd.bsky.social, ResToRes Research integrity in biomedical research, OSIRIS, the @reproductible-fr.bsky.social and Embrace) is now online.

Over the coming days, three independent teams (@sharectd.bsky.social PhD students + clinical & statistical experts) will each conduct their own IPD meta-analysis to answer the same research question. 👉 Can esketamine reduce suicidality?

Stay tuned... I’ll share updates during the week. And @sharectd.bsky.social website is here : www.sharectd.eu

Long time no see, #ScienceSky people! 👋 After a short hiatus, we're reliving the #PeerOnSky series. A "silent" issue in clinical trials: Outcome Reporting Bias (ORB). Let's revisit a classic but vital paper by Smyth et al. (2010) that gets into the heads of trialists. www.bmj.com/content/342/...

#PeerOnSky Article 2! "Meta-analysis of individual participant data: rationale, conduct, and reporting" by Riley et al. (2010). IPD boosts power for subgroups and adjusts for confounders. Read: doi.org/10.1136/bmj.... What challenges do you face in IPD meta-analyses? #OpenScience #MetaAnalysis

A must read work from our network. 👍

🔬 #PeerOnSky starts! “Clinical Trial Participants’ Views of the Risks and Benefits of Data Sharing” by Mello et al. (2018). They found participants value data sharing for science, but worry about privacy breaches. A 2018 perspective still relevant today! Does this reflect current views? #DataEthics

🎉 Hello all! Welcome to #PeerOnSky! It stands as 'Peer discussion on the Sky'. We will dive into cutting-edge research, sparking discussion on BlueSky using the articles discussed within our network. We’ll kick off with a 2018 gem on clinical trial data sharing. #OpenScience #Research #JournalClub

a must read article for the week!

🌧️ Just wrapped Datathon1 at UMC Göttingen, from 07 to 11 July! Part of SHARE-CTD, this in-person event brought doctoral students, PIs, and lecturers together for clinical trials, biostats, and data mgmt. Check the Vibes! #SHARECTD #Datathon #Research #biostatistics

💬 Participants deserve to know! This Trials paper (doi.org/10.1186/s130...) pushes for sharing clinical trial results with participants—because their contributions matter. From a patient’s view, it’s about respect & transparency. Let’s dive in! #ClinicalTrials #Transparency #ShareCTD

🔬 New paper alert! BMC study (doi.org/10.1186/s128...) proposes 6 solutions target ethics, registries, & governance to tackles Germany’s clinical data sharing crisis. Only 2% of medical research shares data—time for change! Read on! #OpenScience #DataSharing #ShareCTD

🔍 Fascinating read! This PLOS Biology paper uncovers misuse of the NHANES dataset by potential paper mills—raising red flags on shared data integrity. Not about trials, but a must-discuss for research ethics. Check it: journals.plos.org/plosbiology/... #ResearchEthics #DataIntegrity #OpenScience

🎉 Today’s the day! ICTD 2025 - Rethinking Clinical Trials: Inclusivity in Practice, co-hosted by ECRIN @ecrin.bsky.social & SCReN in Madrid. How do we turn talk into action for inclusive study design? Tune in online—registration & waitlist are full! ecrin.org/ictd-2025 #ICTD2025 #ClinicalTrials

🎉 Big news for clinical research! SPIRIT2025 just dropped, adding an Open Science section & a new Item No. 6 on data sharing. This pushes transparency in trials—where & how de-identified data, code, & materials will be accessible. Check it: www.consort-spirit.org #OpenScience #ClinicalTrials

🎉 Kudos to Giulia @giulia-varvar.bsky.social for her speed talk at "Printemps de la Recherche" last Tuesday! She presented about SHARE-CTD, and her project on re-analysis of pivotal trials in Oncology, to Irset’s 350+ pros. A great moment to showcase open science in medicine!🔬 #SHARECTD #OpenScience

🙌 Big props to our SHARE-CTD scientist featured in STAT News! His insights on boosting clinical trial transparency in France (only 57% results shared, 2012-2022) are key to open science. 🔬 #SHARECTD #OpenScience #ClinicalTrials #DataSharing

For those of you who are interesed, please join and register

💬 We want to hear from YOU. Are you a: 👨‍🔬 Researcher? 👩‍⚕️ Clinician? 🧑‍💼 Policymaker? 🤔 Just curious? This space is for discussing how data sharing can shape better healthcare. We’ll keep you posted right here on Bluesky. Follow us to stay involved. Let’s share! #ScienceCommunication #DataSharing

🔍 What is SHARE-CTD? We’re a Marie Skłodowska-Curie Action (MSCA) doctoral network funded by the EU. Our mission? To train future experts in clinical trial data sharing, from regulation to ethics to advanced data science. #ClinicalTrials #ResearchTraining #DoctoralNetwork

Welcome to the official Bluesky account of SHARE-CTD! We're a European research network dedicated to enhancing clinical trial data sharing to advance medical research and the betterment of society. Learn more: share-ctd.eu #SHARECTD #OpenScience #DataSharing