Our new preprint: Chromatin at ~10–100 kb scales behaves very differently from standard polymer expectations. DNA-PAINT data reveal broad fluctuations and sharp local bends. Our study suggests emergent active forces at these scales and quantifies the nature and strength of this activity

How does 3D chromatin organization affect translocations? Our work shows that translocation probability depends not just on local contact probability, but also on global chromatin compaction. Cool work by Anirudh (then an MTech student at IIT Bombay) with @shuvadipdutta.bsky.social et al.

Happy to share our Current Opinion review on the key challenges in accurately predicting 3D distances between chromatin segments and computing their dynamics. Thanks to @djost-physbiol.bsky.social @lucagiorgetti.bsky.social for the invitation to write this review! @shuvadipdutta.bsky.social

Sharing our recent review with @ranjithpa.bsky.social on polymer models of chromatin Polymer simulations of chromatin: connecting 3D organization and dynamics to function 👇 www.sciencedirect.com/science/arti... 🧵 (1/6) #Chromatin #GenomeArchitecture #PolymerPhysics #ComputationalBiology

The lab is in a celebratory mood as we head into the Diwali weekend🪔. Wishing everyone a bright, joyful, and prosperous Diwali!🌟. Kudos to Sai, Siddharth, Sriya, Surabhi and team for making this beautiful rangoli!

How do nuclear lamins shape 3D genome organisation? Explore this chapter for a tour through theoretical/computational models revealing multifaceted influence of lamin on chromatin organisation. written together with Mithun Mitra. Read on: doi.org/10.1007/978-...