Rebeca Arroyo
@rebecaarroyo.bsky.social
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Immunologist || Exploring the myeloid-CAR T network || Stanford
reposted by
Rebeca Arroyo
Fletcher Lab
2 months ago
How does a macrophage decide to eat or simply nibble? Check out our latest paper! You can also read this nice review. Congrats Caitlin for leading this amazing work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
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Target cell cortical tension regulates macrophage trogocytosis - Nature Cell Biology
Cornell et al. show that target cells with low cortical tension induce macrophages to preferentially trogocytose, or engulf in small fragments, whereas target cells with high cortical tension tend tow...
https://www.nature.com/articles/s41556-025-01807-6
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Don't miss the morphological transformation pDC → tDC → cDC2 on the cover of Nature Immunology!
www.nature.com/ni/volumes/2...
add a skeleton here at some point
6 months ago
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reposted by
Rebeca Arroyo
6 months ago
Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here:
rdcu.be/eBB5e
www.nature.com/articles/s41...
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TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells
Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....
https://rdcu.be/eBB5e
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Thanks to
@idoyagalab.bsky.social
for supporting my postdoctoral work and making this paper possible. Super excited to show how pDCs regulate their antigen presentation function switching to cDC2!
add a skeleton here at some point
6 months ago
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Paper alert: TNF and IFN-I play opposing roles in regulating pDC antigen presentation. We mapped the pDC-to-cDC reprogramming journey epigenetically, transcriptionally and functionally. And we saw it in action in human aging and inflammation!
doi.org/10.1038/s415...
#pDC
#APC
#TNF
#IFN-I
#immunosky
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TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells - Nature Immunology
Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...
https://doi.org/10.1038/s41590-025-02234-3
7 months ago
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