Rebeca Arroyo
@rebecaarroyo.bsky.social
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📥 103
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Immunologist || Exploring the myeloid-CAR T network || Stanford
Don't miss the morphological transformation pDC → tDC → cDC2 on the cover of Nature Immunology!
www.nature.com/ni/volumes/2...
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about 1 month ago
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reposted by
Rebeca Arroyo
about 2 months ago
Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here:
rdcu.be/eBB5e
www.nature.com/articles/s41...
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TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells
Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....
https://rdcu.be/eBB5e
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Thanks to
@idoyagalab.bsky.social
for supporting my postdoctoral work and making this paper possible. Super excited to show how pDCs regulate their antigen presentation function switching to cDC2!
add a skeleton here at some point
about 2 months ago
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Paper alert: TNF and IFN-I play opposing roles in regulating pDC antigen presentation. We mapped the pDC-to-cDC reprogramming journey epigenetically, transcriptionally and functionally. And we saw it in action in human aging and inflammation!
doi.org/10.1038/s415...
#pDC
#APC
#TNF
#IFN-I
#immunosky
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TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells - Nature Immunology
Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...
https://doi.org/10.1038/s41590-025-02234-3
about 2 months ago
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