Upeksha Dissanayake
@upeksha.bsky.social
📤 5
📥 8
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reposted by
Upeksha Dissanayake
G. Andrés Cisneros
9 months ago
Finally online! Latest paper from our group, by
@upeksha.bsky.social
in collaboration with Carlos Trasviña and Sheila David:
#NIHfunded
rdcu.be/ehTLp
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Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair
Nature Communications - MUTYH removes A mis-incorporated opposite oxidized guanine to thwart mutations. Here, the authors present crystal structures and assess functional impacts and molecular...
https://rdcu.be/ehTLp
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5
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reposted by
Upeksha Dissanayake
G. Andrés Cisneros
10 months ago
Latest paper from the group is out, great contribution by
@upeksha.bsky.social
for a collaboration with CINVESTAV and LANGEBIO colleagues in México
febs.onlinelibrary.wiley.com/doi/10.1111/...
#NIHFunded
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FEBS Press
Reactive oxygen species induce mutagenic DNA lesions, such as 8-oxo-2′-deoxyguanosine (8-oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Speci....
https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.70064
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