Atefeh Pourkhalili Langeroudi
@atefehpourkhalili.bsky.social
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PhD Candidate at Heidelberg University | Cancer Neuroscience at Venkataramani lab
reposted by
Atefeh Pourkhalili Langeroudi
Matthia Karreman
about 1 year ago
Fantastic work by the amazing
@svenjaktetzlaff.bsky.social
,
@ekinreyhan.bsky.social
and the
@venkataramanilab.bsky.social
!! Important and beautiful study ๐คฉ and I am happy and honored to have played a small part in it!
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reposted by
Atefeh Pourkhalili Langeroudi
Winkler Laboratory
about 1 year ago
Important
#cancerneuroscience
work from the amazing
@venkataramanilab.bsky.social
and as shared first
@svenjaktetzlaff.bsky.social
and
@ekinreyhan.bsky.social
! Check it out ๐
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐งตJust in time for : New research from the Venkataramani lab @CellCellPress maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here:
authors.elsevier.com/sd/article/S..
.
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐ Interested in joining our team? We're hiring at all levels - from research technicians, MD and PhD students to postdocs. Contact:
[email protected]
15/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
We are incredibly grateful for the patients, their families and the funding agencies for enabling this research!
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
Sonja Hรคnzelmann,
@matthiakarreman.bsky.social
, Felix Kurz, Manuel Schrรถter, Marc Thieeir, Abigail Suwala, Karin Forsberg-Nilsson, Claudio Acuna,
@saezlab.bsky.social
, Amir Abdollahi, Felix Sahm, Michael Breckwoldt, Bogdana Suchorska, Franz Ricklefs, Dieter Henrik Heiland
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Bluesky
https://arreman.bsky.social
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
@atefehpourkhalili.bsky.social
@ninadrewa.bsky.social
@afaymonville.bsky.social
ville.bsky.social
@ekeifert.bsky.social
eifert.bsky.social
, Julia Wagner,
@stellasoyka.bsky.social
@marccschubert.bsky.social
@nirosansivapalan.bsky.social
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Andres Villegas (@ville.bsky.social)
Systems are life
https://ville.bsky.social
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
So proud of the shared first authors
@ekinreyhan.bsky.social
sky.social
@svenjaktetzlaff.bsky.social
etzlaff.bsky.social
and the entire team of amazing collaborators
@layern.bsky.social
Peter Bengtson, Alina Heuer,
@julianschroers.bsky.social
@afaymonville.bsky.social
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Bluesky
Social media as it should be. Find your community among millions of users, unleash your creativity, and have some fun again.
https://bsky.social
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐ This research showcases the importance of bespoke methods development for Cancer Neuroscience, how it will advance our understanding of (brain) cancer circuits and the development of novel therapeutics for yet incurable tumors. 14/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐ Beyond just mapping, this work provides new therapeutic targets and a platform for testing treatments against these aggressive brain tumors. 13/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐ฆ Lastly, modified rabies viruses to disconnect tumor-connected neurons from brain tumor cells offer a potential novel therapeutic approach. 12/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐ This led us to combine radiation with drugs that reduce neuronal activity. The combination proved more effective at treating tumors than either approach alone. 10/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐ก Radiation therapy revealed something unexpected: It increased neuronal activity and subsequently connections between neurons and tumor cells. 9/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐ A key discovery was the role of cholinergic neurons connected to glioblastoma cells: blocking their communication pathway slowed cortical tumor growth. 8/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐งฌ Using single-cell RNA sequencing and a functional neurotransmitter receptor screening, we found tumor cells express receptors for multiple neurotransmitters. This allows them to receive signals from many different types of neurons. 7/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐ These weren't just local connections. The tumor cells established networks with neurons across different brain regions and even between hemispheres across large distances, showing remarkable integration. 5/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
โก๏ธ The timeline surprised us: Tumor cells formed functional connections with neurons very quickly with neurons within hours in culture and just days in the brain- much earlier than previously known and expected. 4/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐ฌ Our approach used the infection of tumor cells with a modified rabies virus that can only jump once to a directly connected neuron. When a neuron connects to a tumor cell, it lights up, creating a precise map of their connectome. 3/15
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reposted by
Atefeh Pourkhalili Langeroudi
Varun Venkataramani
about 1 year ago
๐งช How do brain tumors communicate with neurons? We developed a tracing system using modified rabies viruses to map these connections across the entire brain, revealing unexpected complexity. 2/15
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reposted by
Atefeh Pourkhalili Langeroudi
Ekin Reyhan
about 1 year ago
Thrilled to share our latest work on how glioblastoma integrates into brain-wide networks using rabies-mediated retrograde tracing!๐ง So grateful to have been part of such a big team effort!
@svenjaktetzlaff.bsky.social
@venkataramanilab.bsky.social
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reposted by
Atefeh Pourkhalili Langeroudi
Svenja Tetzlaff
about 1 year ago
So happy this is finally out๐ thank you for the amazing supervision
@venkataramanilab.bsky.social
, to the best partner-in-crime
@ekinreyhan.bsky.social
and everyone who contributed, such a team effort!๐ง ๐ฌ
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reposted by
Atefeh Pourkhalili Langeroudi
Jeremy Borniger
about 1 year ago
www.cell.com/cell/fulltex...
from the immensely talented Venkataramani group, essential work for cancer neuroscience.
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Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing
Rapid integration of glioblastoma into neuronal circuits promotes glioblastoma invasion and growth, as shown by rabies-based retrograde tracing. Targeting of neuron-tumor networks with pharmacological or rabies-mediated disconnection offers therapeutic potential.
https://www.cell.com/cell/fulltext/S0092-8674(24)01276-5
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