Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...

Out today @ Science: TIR signaling activates caspase-like immunity in bacteria We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase Congrats Francois Rousset, Ilya Osterman and coauthors! www.science.org/doi/10.1126/...

Substrate binding proteins and nanobodies - that’s protein biochemistry heaven. In our new publication we characterized a nanobody that allosterically inhibits the SBP VcSiaP. Amazing job by @nschneberger.bsky.social and thanks to everyone involved! As always a great team effort! rdcu.be/d1foN