We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing. It’s not a toxin. It’s metabolism. The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place. doi.org/10.1126/sciadv.aeb5297

Enterococcus fans: Check out our latest on E. faecalis EET, advancing our understanding of both the fundamental physiology of this bug and new mechanisms of its virulence. This is the product of a thrilling collaboration with friends in Singapore @gthibault.bsky.social led by @aarontan.bsky.social.

www.science.org/doi/10.1126/... Research highlight📖 “…colonizing the gut of autoimmune-prone mice with E. gallinarum led to dissemination of living E. gallinarum to the lymph nodes, liver, and spleen, accompanied by ⬆️TH17 cells at these sites and production of anti-RNA #autoantibodies. “

Have you ever wondered how pathobionts contribute to autoimmunity? In this week's issue of Science Translational Medicine @science.org we elucidate the mechanism how E.gallinarum influences systemic immune responses and aggravates autoimmunity.. #ImmunoSky #Microbiome www.science.org/doi/10.1126/...