8 years of xenografting breast cancer cell lines and thorough characterisation of the resulting mouse models revealed that context really matters. Breast cancer growth morphology and aggressivess are regulated by auto- and paracrine TGF-beta signalling and strongly depend on transplantation method.

Immensely happy and grateful that our paper got featured in the latest highlights in cancer research. Big thanks to the EACR and all co-authors whose efforts went into this piece of work!

Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research. Congrats Thijn! 🎉 @thijnbrummel.bsky.social Full article ➡️ bit.ly/40p4KnK

📢 Are you approaching the epigenetic world? Or you want to know more about ATAC-seq and it's applications? In this case join the @oncodeinstitute.bsky.social workshop that will take place the 19th of September at the @nkinl.bsky.social !! Places are limited to 35!! Subscribe at the following link:

It's been a real pleasure having this joint ICR NKI retreat again. Many thanks for coming over and the truly inspiring discussions!

Excited to share our review on epigenetic reprogramming in brain metastasis. We review published studies on epigenetic drivers and outline future research directions we’re exploring: www.nature.com/articles/s41... @breastcancernow.bsky.social @stefanprekovic.bsky.social @researchireland.bsky.social

Looking forward to this read =)

If you're interested in luminal breast cancer and the advances made in the field, from molecular subtyping to metastatic disease and disease modelling, check out our review, now out in Endocrine-Related Cancer. Thanks @stefanprekovic.bsky.social, @damirvareslija.bsky.social and Hendrik Messal.

📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: bit.ly/3O4bOjq

And lastly, hot off the press in Oncogene, a great effort by the Prekovic lab @stefanprekovic.bsky.social on describing the roles of STAG2 in cohesin biology and cancer: www.nature.com/articles/s41...

Here we describe models for hormone-dependent breast cancer with a thorough focus on rat models generated over the past 100+ years: link.springer.com/article/10.1...

To start up here I'd like to share some of our recently published reviews: