Catrin Lutz
@catrinlutz.bsky.social
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📥 553
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Postdoc at the Netherlands Cancer Institute. Cancer Modeller. Rat Advocate.
8 years of xenografting breast cancer cell lines and thorough characterisation of the resulting mouse models revealed that context really matters. Breast cancer growth morphology and aggressivess are regulated by auto- and paracrine TGF-beta signalling and strongly depend on transplantation method.
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Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness
Establishment and investigation of the largest collection of fully characterized breast cancer cell line xenograft models identifies key determinants of tumor morphology and aggressiveness and enables...
https://aacrjournals.org/cancerres/article-abstract/85/14/2608/763451/Large-scale-Characterization-of-Orthotopic-Cell?redirectedFrom=fulltext
5 months ago
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Immensely happy and grateful that our paper got featured in the latest highlights in cancer research. Big thanks to the EACR and all co-authors whose efforts went into this piece of work!
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5 months ago
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reposted by
Catrin Lutz
Netherlands Cancer Institute
6 months ago
Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research. Congrats Thijn! 🎉
@thijnbrummel.bsky.social
Full article ➡️
bit.ly/40p4KnK
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reposted by
Catrin Lutz
Sebastian Gregoricchio, Ph.D.
7 months ago
📢 Are you approaching the epigenetic world? Or you want to know more about ATAC-seq and it's applications? In this case join the
@oncodeinstitute.bsky.social
workshop that will take place the 19th of September at the
@nkinl.bsky.social
!! Places are limited to 35!! Subscribe at the following link:
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Masterclass: ATAC-seq data analysis and applications | Oncode Institute
By Sebastian Gregoricchio (lab Wilbert Zwart, Netherlands Cancer Institute)
https://oncodeinstitute.nl/events/masterclass-atac-seq-data-analysis-and-applications
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It's been a real pleasure having this joint ICR NKI retreat again. Many thanks for coming over and the truly inspiring discussions!
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8 months ago
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reposted by
Catrin Lutz
Damir Vareslija
10 months ago
Excited to share our review on epigenetic reprogramming in brain metastasis. We review published studies on epigenetic drivers and outline future research directions we’re exploring:
www.nature.com/articles/s41...
@breastcancernow.bsky.social
@stefanprekovic.bsky.social
@researchireland.bsky.social
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The epigenetic landscape of brain metastasis - Oncogene
Oncogene - The epigenetic landscape of brain metastasis
https://www.nature.com/articles/s41388-025-03315-1
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Looking forward to this read =)
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11 months ago
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If you're interested in luminal breast cancer and the advances made in the field, from molecular subtyping to metastatic disease and disease modelling, check out our review, now out in Endocrine-Related Cancer. Thanks
@stefanprekovic.bsky.social
,
@damirvareslija.bsky.social
and Hendrik Messal.
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11 months ago
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reposted by
Catrin Lutz
Netherlands Cancer Institute
about 1 year ago
📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities
#PhD
#CancerResearch
More info:
bit.ly/3O4bOjq
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And lastly, hot off the press in Oncogene, a great effort by the Prekovic lab
@stefanprekovic.bsky.social
on describing the roles of STAG2 in cohesin biology and cancer:
www.nature.com/articles/s41...
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Emerging roles of cohesin-STAG2 in cancer - Oncogene
Oncogene - Emerging roles of cohesin-STAG2 in cancer
https://www.nature.com/articles/s41388-024-03221-y
about 1 year ago
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Here we describe models for hormone-dependent breast cancer with a thorough focus on rat models generated over the past 100+ years:
link.springer.com/article/10.1...
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Rat Models of Hormone Receptor-Positive Breast Cancer - Journal of Mammary Gland Biology and Neoplasia
Hormone receptor-positive (HR+) breast cancer (BC) is the most common type of breast cancer among women worldwide, accounting for 70–80% of all invasive cases. Patients with HR+ BC are commonly treate...
https://link.springer.com/article/10.1007/s10911-024-09566-0
about 1 year ago
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To start up here I'd like to share some of our recently published reviews:
about 1 year ago
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