David Steffin
@davidsteffin.bsky.social
📤 62
đź“Ą 46
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Cell therapy trials for solid tumors, pediatric bone marrow transplant
Very promising news and an honor to be a part of this report!
@bcmhouston.bsky.social
@texaschildrens.bsky.social
www.nature.com/articles/s41...
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Long-term outcomes of GD2-directed CAR-T cell therapy in patients with neuroblastoma - Nature Medicine
In an extended follow-up of a phase 1 trial evaluating a first-generation GD2-directed CAR-T cell therapy in patients with neuroblastoma, one patient has had a sustained clinical response for over 18 ...
https://www.nature.com/articles/s41591-025-03513-0
8 months ago
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reposted by
David Steffin
11 months ago
IL15 increases the expansion of CAR T cells and induces antitumor responses in patients with GPC3+ solid tumors (i.e. liver cancer).
rdcu.be/d2faz
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Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers
Nature - We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion,...
https://rdcu.be/d2faz
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reposted by
David Steffin
Science News
11 months ago
#NatureNews
New, Effective CAR-T Strategy IL-15 increases the expansion, intratumoural survival and antitumour activity of GPC3 CAR T cells in patients.
#Medsky
#scisky
#News
#CART
#Oncology
#Cancer
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Promising results from our phase 1 trials using GPC3-CAR T cells co-expressing IL-15 in relapsed/refractory solid tumors.
@natureportfolio.bsky.social
@bcmhouston.bsky.social
@andrasheczey.bsky.social
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https://www.nature.com/articles/s41586-024-08261-8
https://t.co/P2fxyC2Pmk
11 months ago
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