@basgrootkoerkamp.bsky.social
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reposted by
Marc Besselink
8 months ago
Can
#Video
Grading of Bile Duct Anastomoses During Robotic 🤖
#Pancreatoduodenectomy
Predicts Bile Leak (BL)? ✅ Videos from 259 pts robotic HJ: 6.9% B/C BL ✅ OSATS score <21 assoc with BL ✅ The rate of BL was 5.1% for OSATS>21 vs 12.5% for OSATS ≤21 ▶️
journals.lww.com/annalsofsurg...
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reposted by
Syed A Ahmad, MD
8 months ago
Failure to Rescue After Resection of Perhilar Cholangiocarcinoma in an International Multicenter Cohort @AnnSurgOncol
link.springer.com/article/10.1...
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Failure to Rescue After Resection of Perhilar Cholangiocarcinoma in an International Multicenter Cohort - Annals of Surgical Oncology
Background Failure to rescue (FTR) is defined as the inability to prevent death after the development of a complication. FTR is a parameter in evaluating multidisciplinary postoperative complication m...
https://link.springer.com/article/10.1245/s10434-024-16293-7
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reposted by
Giovanni Marchegiani, MD PhD
8 months ago
🧪 CA19.9 response after induction FOLFIRINOX for LAPC
@bjsurgery.bsky.social
1k LAPC chemo ➡️ restaging 23% M1 😢 24% underwent surgery 🪡 📉 Baseline CA19.9 Not predictor of survival 📈 CA19.9 after induction / decrease 80% best survival
academic.oup.com/bjs/article/...
@bjsacademy.bsky.social
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reposted by
Syed A Ahmad, MD
8 months ago
Hepatocellular carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up @Annals_Oncology
www.sciencedirect.com/science/arti...
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Hepatocellular carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
https://www.sciencedirect.com/science/article/pii/S0923753425000730
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reposted by
Giovanni Marchegiani, MD PhD
8 months ago
🧬 RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer 🎯 A milestone one in
@nature.com
🦠 Responders with vaccine induced t-cells have prolonged RFS compared to non responders 💉 Vaccine for PDAC not a dream anymore
www.nature.com/articles/s41...
#PancreaSky
#HPBSky
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reposted by
BJS Academy
8 months ago
📝 Want to know how to write a clinical paper? We have a 4️⃣ part series dedicated to just that! 📽️ Watch part 2️⃣, taught by
@villesallinen.bsky.social
, Editor-in-Chief, of
@bjsopen.bsky.social
here ➡️
https://buff.ly/4b3QNzN
#SurgSky
#MedSky
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How to write a clinical paper – Part 2 of 4
Short BJS Course â Part 2 of 4 Ville Sallinen, Editor-in-Chief, BJS Open
https://buff.ly/4b3QNzN
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reposted by
Syed A Ahmad, MD
8 months ago
The Duration of Immunotherapy for Mismatch Repair–Deficient Cancers @NEJM
www.nejm.org/doi/full/10....
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The Duration of Immunotherapy for Mismatch Repair–Deficient Cancers | NEJM
An analysis of published studies suggests that a longer duration of immune checkpoint inhibitor therapy is associated with a higher incidence of complete response among patients with mismatch ...
https://www.nejm.org/doi/full/10.1056/NEJMc2409154
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reposted by
Prof. Feynman
10 months ago
The pleasure of finding things out is one of the greatest rewards of the human spirit.
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reposted by
Giovanni Marchegiani, MD PhD
10 months ago
Perioperative Corticosteroids 💊 to reduce complications in pancreas surgery? 🧐 Meta analysis 5 studies / 1.4k pts
@annsurgoncology.bsky.social
Corticosteroids🫸🫷no dicrease morbidity / fistula / mortality 💡 What about mitigation strategis in high risk!?
#HPBSky
link.springer.com/article/10.1...
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reposted by
Prof. Feynman
10 months ago
There is no learning without having to pose a question. And a question requires doubt.
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reposted by
Maarten van Smeden
10 months ago
Let us start 2025 in a positive mood: here are 10 methods things researchers can worry *less* about in 2025
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reposted by
Marc Besselink
10 months ago
Nationwide 🇳🇱 outcome
#robot
🤖 vs
#laparoscopic
#liver
#surgery
? 🔑 Robot ⬇️conversion 🔑 Robot ⬇️ hospital stay 🔑 Robot ⬇️ blood loss 🔑 Robot benefits mostly based on less conversions ▶️
journals.lww.com/aosopen/full...
@eahpba.bsky.social
@ihpba.bsky.social
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reposted by
Syed A Ahmad, MD
10 months ago
Mechanisms of metastatic colorectal cancer @NatRevGastroHep
www.nature.com/articles/s41...
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Mechanisms of metastatic colorectal cancer - Nature Reviews Gastroenterology & Hepatology
Metastatic colorectal cancer (mCRC) has a poor prognosis, and therapeutic options are limited. This Review provides a comprehensive overview of the genetic and molecular underpinnings of mCRC, discuss...
https://www.nature.com/articles/s41575-024-00934-z
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reposted by
Syed A Ahmad, MD
10 months ago
PDAC: advances in tumour microenvironment, microbiome and AI @NatRevGastroHep
www.nature.com/articles/s41...
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PDAC: advances in tumour microenvironment, microbiome and AI - Nature Reviews Gastroenterology & Hepatology
Pancreatic cancer remains one of the most challenging malignancies, with a very poor prognosis. Current research is focused on elucidating the role of the tumour microenvironment and the microbiome in...
https://www.nature.com/articles/s41575-024-01030-y
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reposted by
Ville Sallinen
10 months ago
Our MOBILE2 trial Top4 viewed paper
@jama.com
/surgery with >30k views! And total two papers from Finland🇫🇮 on Top10 list. Many more trials already running, quite a few in the pipeline to be started, several new ideas under marinade!
read.alerts.jamanetwork.com/csb/Public/s...
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Most Viewed Articles 2024
http://read.alerts.jamanetwork.com/csb/Public/show/axac-2vszng--18r1nu-jkbfvgd3?utm_source=twitter&utm_medium=social_jamasurg&utm_term=15635964383&utm_campaign=amplification&linkId=696122624
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reposted by
Prof. Feynman
10 months ago
Play with ideas the way children play with toys—without fear of breaking them.
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reposted by
Giovanni Marchegiani, MD PhD
10 months ago
2️⃣0️⃣2️⃣4️⃣ Pancreas Wrapped 🎄 6️⃣ June 🍇 How to prevent IPMN progression to cancer?! 🫸 🚬 Quit smoking is THE answer! Smoke correlates with HGD and invasive cancer 🚨
www.dldjournalonline.com/article/S159...
#HPBSky
#PancreasSky
#SurgSky
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reposted by
Syed A Ahmad, MD
10 months ago
Long term outcomes in EDPAC 4. The median OS was 29.5 months (27.5-32.1) for all patients, 28.4 months (25.2-32.0) in the gemcitabine group and 31.6 months (26.5-38.0) in the GemCap group
ascopubs.org/doi/10.1200/...
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Pancreatic Adenocarcinoma: Long-Term Outcomes of Adjuvant Therapy in the ESPAC4 Phase III Trial
PURPOSEThe ESPAC4 trial showed that adjuvant chemotherapy with gemcitabine plus capecitabine (GemCap) produced longer overall survival (OS) than gemcitabine monotherapy. Subsequently, the PRODIGE24-CC...
https://ascopubs.org/doi/10.1200/JCO.24.01118
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reposted by
Memorial Sloan Kettering Cancer Center
11 months ago
A new study in
@cellpress.bsky.social
Immunity from the lab of Dr. Benjamin Greenbaum provides insights into how
#PancreaticCancer
cells accommodate active retrotransposons without triggering the innate immune response.
#oncsky
#medsky
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Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms
Overexpression of transposable elements is a common feature of cancer. Sun, You, et al. show that, in pancreatic ductal adenocarcinoma, tumor cells adapt through different mechanisms to mitigate a spe...
https://www.cell.com/immunity/fulltext/S1074-7613(24)00494-1
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reposted by
Syed A Ahmad, MD
11 months ago
Adjuvant chemotherapy for adenocarcinoma arising from intraductal papillary mucinous neoplasia: multicentre ADENO-IPMN study
academic.oup.com/bjs/article/...
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Validate User
https://academic.oup.com/bjs/article/111/4/znae100/7657646
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reposted by
Marc Besselink
11 months ago
Today
#JAMAsurg
: long term outcomes
#ESCAPE
RCT: early
#surgery
remains superior to
#endoscopy
first in pts with wide-duct
#chronic
#pancreatitis
✅ Lower Izbicki pain scores ✅ Lower number of reinterventions ✅ Lower VAS pain scores ✅ Higher patient satisfaction ▶️
jamanetwork.com/journals/jam...
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