Recently, I sat down with Paul Taylor to discuss the intimate links between lysosomal health and aging. We touched on so many important topics in this one, with an overarching focus on practical, science-backed strategies for living a healthier life. 🧪 #Longevity

Last week, I sat down with David Blackmore to walk through my personal #longevity strategy. He did an excellent job distilling our conversation into key takeaways, focusing on diet, exercise, and drugs/supplement approaches. 🧪

David Roberts and Mara Labs just posted a nice, concise article on the #microplastics health problem and #sulforaphane as a potential tool for liberating the particles from cells. 🧪 Definitely worth a read if you are looking for a quick intro. mara-labs.com/blogs/journa... #Longevity

Lithium prevents Alzheimer’s. Here’s how to use it. 🧪 jonbrudvig.substack.com/p/lithium-pr... #Alzheimer's #Longevity #Prevention

Even as evidence builds, many experts hesitate to recommend lithium for Alzheimer’s prevention. That’s a mistake. 🧪 My latest post breaks down the science and gives practical recommendations for implementation. jonbrudvig.substack.com/p/lithium-pr... #Alzheimer's #Longevity #BrainHealth

What’s the rationale for and against metformin for #longevity? First, how does it work? As we’ve discussed in recent posts, metformin acts in the gut by binding a lysosomal protein called PEN2 and activating a response that increases production of incretin hormones like GLP-1, GIP, and PYY. 🧪

This week in the Lancet: “Plastics cause disease and death from infancy to old age and are responsible for health-related economic losses exceeding $1.5 trillion annually.” 🧪 A quick break down and call to action in this thread. #Microplastics #Longevity

It was fun to see Felix Harder break down my #microplastics experiments on YouTube 🧪: www.youtube.com/watch?v=JZaJ... I'm working on a follow up post now, with a science update and protocol insights. Stay tuned! Original post on Substack: jonbrudvig.substack.com/p/first-evid...

Metformin doesn’t just lower glucose; it teaches your gut how to sense nutrients again. Two new papers show exactly how this works, and why it matters. 💊🧪💊 Broken down in this thread. #Longevity #Aging #Healthspan

Life is Shorter Than You Think. Don’t Miss Your Bonus Chapter. My new full-length post is a simple inquiry into the true impact of lifestyle interventions, with simple, striking visuals that reframe the entire question. jonbrudvig.substack.com/p/life-is-sh... #Longevity #Healthspan #Aging 🧪

Psilocybin extends lifespan in mice. But this is bigger than just a new geroprotective drug; it suggests an entirely new drug target—and it probably isn't the one you think. 🧪🧠🧪 substack.com/profile/1091... #longevity #psychedelics #psilocybin

In case you missed it, my last Substack post summarizes the #microplastics problem for human health and shares some encouraging initial experiments into a clearance protocol. This one has generated a LOT of great discussion. Next steps are in the works! 🧪 jonbrudvig.substack.com/p/first-evid...

What if a quick blood test could tell you how fast each of your organs are aging? 🧪🩸🧪 That’s the promise of Vero Bioscience, a new startup commercializing the organ-specific aging test developed by the Wyss-Coray group at Stanford. Broken down in this thread. #Longevity #Aging

This changes the scale of the #microplastics crisis. We’ve known about the 3 million tonnes (MT) of floating plastic in our oceans for years. But that’s just the surface. In the North Atlantic alone, 27 MT (9x!) of nanoplastics are suspended in the water column. 🧪 www.nature.com/articles/d41...

#Inflammaging isn’t a biological inevitability. It’s a byproduct of industrialized lifestyles, as confirmed in a new study this week in Nature Aging. Broken down in this thread. 🧪

#Microplastics are building up in your body. You can reduce your exposure, starting with three major sources you probably haven’t even thought about. 🧪🔬🪥

Turning #microplastics into Tylenol? 🧪 This isn't going to solve the plastic mess we've created, but it does illustrate how bacteria can be engineered to break down plastic, sometimes with useful bioproducts. Microbes may be the solution to the environmental problem. www.nature.com/articles/d41...

I've noticed a lot of recent pushback on the notion of #longevity medicine 🧪 in the popular press. Respected clinicians, scientists, and thought leaders (including one of my favorites, Eric Topol) repeat the claim that “there is no evidence for these treatments.” This is objectively false.

Myostatin inhibitors have received a lot of attention in the muscle space. They work great in mice, but there's another strategy with far greater potential in humans. I break down the #Science in this thread. 🧪💊🧪 #myostatin #muscle #healthspan #longevity

Do #psychedelics and SSRIs actually relieve #depression through serotonin, or is it something else entirely? Recent evidence points to a surprising answer, broken down in this thread. 💊🧪💊

After sharing this initial report, there's been a lot of great discussion around implications and next steps. 💊🧪💊 Check it out on Linkedin: www.linkedin.com/posts/jon-br... And the full post on Substack: substack.com/home/post/p-... #microplastics #longevity #healthspan

The secretome of senescent monocytes predicts age-related clinical outcomes in humans www.nature.com/articles/s43...

Your cells can’t digest microplastics, but they can be tricked into spitting them out. Here’s the first evidence that it works in humans. 🧪 jonbrudvig.substack.com/p/first-evid... #microplastics #longevity #sulforaphane

Aging and disease accelerate when lysosomes fail, and slow down when we fix them. 💊🧪💊 This is an underappreciated, shared mechanism contributing to everything from cellular senescence and #inflammaging to mitochondrial dysfunction and Parkinson's disease.

Metformin became a first-line therapy long before we figured out how—or even where—it actually worked. It turns out the gut, not the liver, is the primary site of action. 🧪 I break down the data on LinkedIn: www.linkedin.com/feed/update/... #Longevity #DrugDevelopment

New Bluesky Feed - Longevity! Please like and pin the feed! bsky.app/profile/did:... Moderation List - bsky.app/profile/scie... Allowlist - bsky.app/profile/did:... #longevity #aging #lifeextension #science #gerontology

I appreciate the innovation… but did it have to go on the face? If it does, can we at least make it look like some badass Old English lettering or something? 😅 #Wearables #Longevity #BrainHealth 🧪

Bumping this one for the #Science feed! 🧪

Reducing exposure is one way to reduce #microplastics. But what about eliminating those already in our bodies? My new self-experiment shows how a simple supplement protocol can stimulate cells to dump internalized microplastics into the bloodstream. Full write up soon. #Longevity #Biohacking

Despite being one of the world's most prescribed drugs for several decades, we didn't really know how metformin worked until 2022. Hundreds of publications state that metformin works by inhibiting mitochondrial complex I, reducing ATP levels and increasing the AMP/ATP ratio to activate AMPK. 🧪

We’re finally entering the era where we can map precisely how gut microbes modulate human health. A new study just revealed one such pathway. A fungal microbe inhibits a gut enzyme, decreasing ceramide and inflammation. = new and better drug targets!🧪 www.science.org/doi/10.1126/... #microbiome

What makes a human brain human? A new study may have found part of the answer: a stretch of DNA that doesn’t exist in other primates. When added to mice, it enlarged their brains. 🧪🧠🐭 (Paywalled) Article: www.nature.com/articles/s41... Preprint: www.biorxiv.org/content/10.1... #Neuroscience #Brain

Glucose control is one of the most powerful—and underappreciated— #longevity strategies. I just posted a new Substack where I break down the science and share CGM results from a self-experiment comparing acarbose vs. 8 OTC alternatives. Full results 🧪👇🧪 jonbrudvig.substack.com/p/stop-the-s...

☕ Good news, #coffee people. You might be protecting yourself from frailty later in life. A new study found a striking dose–response: the more coffee older adults drank, the lower their odds of frailty. Drink up! 🧪☕💊 #Longevity #Healthspan link.springer.com/article/10.1...

Physicists at CERN turn lead into gold, vindicating centuries of spurned alchemists.🧪😜🧪 www.nature.com/articles/d41...

We may never fully escape environmental toxins. But what if engineered gut bacteria could neutralize them before they enter the bloodstream? 💊🧪💊 That's exactly what this new study shows, with an engineered probiotic that neutralizes dietary methyl-mercury. www.sciencedaily.com/releases/202...

What if you could still crave junk food, but just... not eat it? GLP-1s seem to create that disconnect, and we still don't quite understand how. Consumption of processed foods, sugary drinks, refined grains, beef, and pork all decline. 🧪 #GLP1 www.sciencedirect.com/science/arti...

A man gave himself 200 potentially deadly snake bites. Now his antibodies are is being used to make universal antivenom. 🧪 This is either the most badass or idiotic #biohacking experiment ever. Slayer shirt suggests the former. 🤘🎸🤘 Which is it? www.nature.com/articles/d41...

A tardigrade just got the world's tiniest tattoo. This, and so much more, in Nature's roundup of the best #science images from April. 🧪 And yes, you should take 20 seconds to play the aurora video. 😍 www.nature.com/immersive/d4... #SciencePhotography #Microscopy

What if each branch of a neuron was its own processing unit? That would mean the brain’s computational power isn’t just spread across billions of neurons, but across billions of branches within them.🧪 🤯 🧪 New findings suggest that’s exactly how the #brain works. www.science.org/doi/10.1126/...

The world’s top aging researchers just released a joint statement: Aging is modifiable. Healthspan can be extended. But just as breakthroughs are accelerating, funding is drying up. 🧪 Longevity science doesn’t have a lobby. It needs us to spread the word. Repost if you agree. www.ahlresearch.org

Lysosomal dysfunction drives cellular decline both in rare diseases and in the normal aging process. Could a single intervention help both? 🧪💊🧪 A quick breakdown of a new therapy candidate in this thread. #Longevity #Aging #Healthspan elifesciences.org/articles/103...

New study: TCF1, a key immune regulator, is linked to 15 extra years of life. It supports T cell renewal, reduces inflammation, and lowers senescent cell burden. Several #longevity interventions may boost it: 💊Rapamycin 🧪SGLT2 inhibitors 💊Low-dose lithium pubmed.ncbi.nlm.nih.gov/40264357/

I just launched a new starter pack for anyone looking to dive deeper into health and longevity on Bluesky. This is a balanced list of scientists, communicators, and advocates, all of whom regularly post valuable evidence-based content on #aging, #longevity, and #healthspan! 🧪🔬💊 go.bsky.app/D7Snnab

"Exclusive: a Nature analysis signals the beginnings of a US science brain drain A trawl of job views and application data suggests jobseekers are looking abroad as the Trump administration’s cuts to science take hold." How is this a good thing for America? 🧪 www.nature.com/articles/d41...

Clinical blood tests will soon predict your risk for chronic diseases and assess how fast each of your organs are aging. Mainstream adoption will take years, but you don't have to wait for medicine to catch up! The tests in this thread are available now! #Longevity 🧪🩸🧪 substack.com/redirect/fc8...

We’ve been told that long telomeres mean a longer life. But this 116-year-old (once the world’s oldest person) had telomeres far shorter than average. Emerging evidence suggests that telomeres are simply not a limiting factor for longevity in humans. 🧬🧪🧬 www.biorxiv.org/content/10.1... #longevity

Is red wine good or bad for longevity? The science is more surprising than you’d think. I break down the latest data in a new post: 🍷🧪🍇 jonbrudvig.substack.com/p/feeling-a-... #longevity

An entirely new class of senotherapeutics was just discovered in mice. This one is derived from the Reishi mushroom and works by stabilizing ribosomes (the machinery for making new proteins), preventing cellular senescence. Great effects on frailty! 🧪 www.nature.com/articles/s41... #longevity

Chris Masterjohn just posted a provocative teardown of rapamycin as a longevity intervention, calling it “the worst longevity idea ever conceived.” Here’s why he is wrong. 🧪 substack.com/@jonbrudvig/... #Longevity