We’re proud to announce Chloe Langridge as a 2025 HDBuzz Prize winner! Her article covers work that shows that boosting a protein called SGTA can ease signs of Huntington’s disease, opening a potential new therapeutic path. en.hdbuzz.net/2025-hdbuzz-...

September’s research highlights: gene therapy that may slow HD, new biomarkers for tracking, deeper mechanistic understanding, and advances in mental health. Progress in HD science continues to accelerate with your support! en.hdbuzz.net/september-20...

Hope is building—over $10k raised toward our $30,000 goal! Every dollar helps bring clear science to the HD community. Spread the word or donate to keep the momentum! Donate here: en.hdbuzz.net/donate

uniQure reports promising results from a key clinical study, showing that its experimental gene therapy, AMT-130, may slow the progress of Huntington's disease en.hdbuzz.net/the-first-do...

SKY-0515, an oral drug, safely lowers huntingtin in people with HD—and may also reduce PMS1, a DNA repair protein. This two-pronged approach could open new doors for HD treatment. A larger Phase 2/3 trial is now underway. Full article: en.hdbuzz.net/sky-0515-low...

We’re proud to announce Jenna Hanrahan as a 2025 HDBuzz Prize winner! She covers research showing that people with HD may not always recognize their symptoms, not from denial, but because of real brain changes. New MRI scans are helping uncover why. en.hdbuzz.net/2025-hdbuzz-...

Webinar: Could DNA repair hold the key to treating Huntingtons disease?🧬 Join UK DRI Group Leaders Profs Sarah Tabrizi & Gabriel Balmus as they dig into the latest discoveries and therapeutic breakthroughs from the field 🗓️ Mon 29 Sep 🕓 4-5pm (BST) Register free 👉 www.ukdri.ac.uk/events/rethi...

Pridopidine has been studied for decades as a possible treatment for Huntington’s disease. The PROOF-HD trial didn’t meet its primary goals, but its full results are now published—making valuable data available for the HD community. en.hdbuzz.net/proof-in-the...

We’re proud to announce Nicolo Zarotti as a 2025 HDBuzz Prize winner! He covers a case study shows that Acceptance & Commitment Therapy (ACT) can lift mood, improve quality of life for people with HD, and offer real support for caregivers too. en.hdbuzz.net/2025-hdbuzz-...

We’re thrilled to announce Eva Woods as a 2025 HDBuzz Prize winner! She covers how a team discovered subtle brainwave shifts in people with HD before symptoms appear. These early electrical “whispers” of HD could one day help track the disease years ahead of diagnosis. en.hdbuzz.net/2025-hdbuzz-...

This fall, we’re excited to launch our Falling Into Hope campaign! Our goal: raise $30,000 in just 8 weeks, by October 28. Learn more about the fundraiser here: en.hdbuzz.net/falling-into...

From gut microbes to muscle health, August’s HD research uncovered new biomarkers, protein maps, and lifestyle clues. Each finding brings us closer to earlier detection and smarter treatments. Full Article: en.hdbuzz.net/august-2025-...

Check out my latest article with @hdbuzzfeed.bsky.social l on a very important, but under researched area in the HD field. 💜

Two studies reveal how a tiny change in FAN1—a DNA repair protein—weakens its hold on DNA, fueling repeat expansions and speeding up Huntington’s disease symptoms. en.hdbuzz.net/when-dna-rep... #HDAwareness #huntingtonsdiseaseawareness #huntingtonsdisease #HDResearch

👪 In my latest piece with @hdbuzzfeed.bsky.social, I explore an important study that puts words to something many of us from families with HD have felt. This study investigates how emotional experiences in childhood can shape our mental health well into adulthood. en.hdbuzz.net/carried-from...

Scientists have captured detailed images of the toxic clumps formed by huntingtin. These insights reveal how the fibers assemble—and how their structure might be altered—opening new doors for potential therapies. Full article; en.hdbuzz.net/cracking-the...

Biomarkers are a powerful tool in Huntington’s disease research. A new blood study highlights two proteins, CAP1 and CAPZB, that could one day help track the disease—even before symptoms appear Full article: en.hdbuzz.net/city-under-t...

The gut and brain talk nonstop along a busy two-way superhighway. In Huntington’s disease, this route can get jammed, rerouted, or even carry harmful cargo — connecting gut microbes, inflammation, and brain health in unexpected ways. en.hdbuzz.net/the-gut-brai...

Full article: en.hdbuzz.net/carried-from...

Huntington’s isn’t just a brain disease — it affects the whole body. New research shows that muscle, fat, and nutrition changes can happen early in HD, even before symptoms are obvious. Keeping an eye on these shifts could help to receive better care. Full Article: shorturl.at/j0Xgc

Today we're spotlighting an article from April 2025 highlighting how research links antidepressant use to faster cognitive decline in people with dementia, but don’t jump to conclusions for Huntington’s disease. HD is different, and more research is needed before applying these findings.

Can timing your meals help the brain? A new review looks at time-restricted eating (TRE) as a potential way to support brain health in Huntington’s disease. While early animal research is exciting, there are real risks to consider for people with HD. Full Article: en.hdbuzz.net/appetite-for...

July’s Huntington’s research highlights: From brain scans to smartphones, scientists are uncovering new ways to track and treat HD. This month’s breakthroughs span gene editing, glial cells, sleep, and cell energy—bringing hope for earlier, more precise interventions. en.hdbuzz.net/july-2025-th...

New insights reveal that disrupted sleep and circadian rhythms surface long before motor symptoms in Huntington’s disease linked to thinking changes, mood shifts, and nerve damage. Understanding and treating these sleep disturbances could open pathways to preserving brain health. shorturl.at/umZlH

The EMA has rejected approval of pridopidine for Huntington’s disease in Europe. While disappointing, the decision aligns with clinical trial data. Prilenia plans further studies, and HD research in 2025 continues to build momentum and hope. Full article: shorturl.at/3to22

Huntington’s unfolds like a symphony gone wrong: Overactive. Out of sync. Then silence. New research reveals the rhythm of HD across time. Full article: en.hdbuzz.net/when-the-brains-orchestra-falls-out-of-tune-a-new-map-of-huntingtons-disease-progression

Read Here: en.hdbuzz.net/unlocking-th... #HDAwareness #HDResearch #HDCommunity #HealthyLiving #HuntingtonsDisease

Did you know?

Red Light, Green Light: How Huntington’s Disease Influences Genetic Traffic Lights https://en.hdbuzz.net/435

Navigating the Genetic River: How Tiny Variants Could Shift the Course of Huntington’s Disease https://en.hdbuzz.net/434

Votoplam, the daily pill from PTC Therapeutics, has met its primary endpoint in the PIVOT-HD clinical trial - it can lower huntingtin protein levels. This latest data update also provides insights into safety, biomarkers, and clinical measures.

Excitement and Anticipation as PTC’s Huntington’s Disease Drug Clears a Major Hurdle to Sprint Home https://en.hdbuzz.net/433

What’s Good for Your Heart is Good for Your Brain: New Study Links Cardiovascular Health to Brain Aging https://en.hdbuzz.net/432

Did you know? Huntington’s disease is thought to affect about 1 in 7000 people. That’s about the same prevalence as ALS! #HuntingtonsDisease #HDResearch #HealthyLiving #HDCommunity

Assembly Line Breakdown: Protein Production Problems in Huntington’s Disease https://en.hdbuzz.net/431

Imagine battling a disease that affects your body and causes your mind to lose touch with reality. This is the reality for many people living with Huntington’s disease (HD) who experience psychosis. Researchers investigated how psychosis symptoms in HD may affect these people. en.hdbuzz.net/424

With so much science going on in the Huntington’s disease space, we’re bringing you a monthly recap from March 2025 to cover all the biggest HD science news and research we covered this month. Enjoy! en.hdbuzz.net/421

April 2025: This Month in Huntington’s Disease Research https://en.hdbuzz.net/430

Stopping C-A-G Repeat Expansion In Its Tracks https://en.hdbuzz.net/429

Ten Golden Rules for Navigating Huntington’s Disease Research News https://en.hdbuzz.net/428

It's Good News Thursday! UniQure has been granted Breakthrough Therapy designation for AMT-130. Development and review will be expedited. Woohoo! It's given to drugs that could treat a serious condition and have prelim clinical support for solid improvement on clinically significant endpoints.

Roche provides an update on tominersen: What’s next for this huntingtin-lowering drug? https://en.hdbuzz.net/427

Nat Biotech featured Huntington's disease (HD) therapeutics and clinical trials. Drawing attention to HD in high impact journals like this is great for showcasing the exciting things going on in HD research to a broad scientific readership. A big win! www.nature.com/articles/s41...

Knockouts for the win: how expanding CAGs drive disease https://en.hdbuzz.net/426

Piecing It Back Together: Growing new neurons for Huntington’s disease https://en.hdbuzz.net/425

Stars in the Sky: Psychosis in Huntington’s Disease https://en.hdbuzz.net/424

We all know that exercise is good for our bodies, but what if working out your brain could slow down Huntington’s disease (HD)? Researchers found that staying mentally active throughout your life might actually help slow brain shrinkage and symptom progression in people with HD. en.hdbuzz.net/411

Do Antidepressants Affect Cognitive Decline? What Huntington’s Disease Families Should Know https://en.hdbuzz.net/423

Hope in Full Bloom: Why Your Support Matters Now More Than Ever https://en.hdbuzz.net/422